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Phosphatidylinositol 3-kinase catalytic delta polypeptide

p110delta, PI3K
Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: PI3K, Akt, V1a, mTOR, CAN
Papers using p110delta antibodies
Signal transducer and activator of transcription 3 (STAT3) and Suppressor of Cytokine Signaling (SOCS3) balance controls cytotoxicity and IL-10 expression in decidual-like natural killer cell line NK-92
Supplier
Jacobs Roland, In PLoS ONE, 2010
... phospho-MAPKp44/42, anti-human SOCS3, anti-human phosphor-STAT3 antibodies, the U0126 (inhibitor of ERK1/2) and wortmannin (inhibitor of PI3K) were obtained from Cell Signaling Technology (Boston, MA, USA) ...
Decreased Level of PDCD4 (Programmed Cell Death 4) Protein Activated Cell Proliferation in the Lung of A/J Mouse.
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Hotchin Neil A., In PLoS ONE, 2009
... Phosphoinositide 3-kinase (PI3K) inhibitor LY294002 (Cell Signaling Technology Inc., Danvers, MA), ...
Simultaneous determination of baicalin, baicalein, wogonin, berberine, palmatine and jatrorrhizine in rat plasma by liquid chromatography-tandem mass spectrometry and application in pharmacokinetic studies after oral administration of traditional Chinese medicinal preparations containing scutellaria-coptis herb couple
Supplier
Ma Jin Yeul et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2009
... RIPA buffer and PI3K inhibitor, LY294002, were obtained from Millipore (Billerica, MA, USA) and Cell Signaling (Danver, MA, USA), respectively ...
Age- and diet-specific effects of variation at S6 kinase on life history, metabolic, and immune response traits in Drosophila melanogaster.
Supplier
Harrison Jeffrey K., In PLoS ONE, 2009
... Phospho-S270 of IRS-1 and PI3k-p85a antibody were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Estrogen receptor-alpha (ER-alpha) suppresses expression of its variant ER-alpha 36
Supplier
Wang Zhao-Yi et al., In Oncogene, 2008
... The MEK1/2 inhibitor U0126, the Src inhibitor PP2, and the PI3K inhibitor LY294002 were from Tocris Bioscience (Ellisville, MO) ...
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Papers on p110delta
Folic acid stimulation of neural stem cell proliferation is associated with altered methylation profile of PI3K/Akt/CREB.
New
Huang et al., Tianjin, China. In J Nutr Biochem, 30 Apr 2014
Gene network analysis revealed links with steroid biosynthesis, fatty acid elongation and the PI3K/Akt/CREB, neuroactive ligand-receptor interaction, Jak-STAT and MAPK signaling pathways.
New methods to control neuroblastoma growth.
Review
New
Dent, Richmond, United States. In Cancer Biol Ther, 11 Apr 2014
UNLABELLED: Downstream of growth factor receptors, signaling by the phosphoinositide 3 kinase (PI3K) pathway is known to play an important role in the growth and survival of many tumor types.
The emerging roles of ARID1A in tumor suppression.
Review
New
Shih et al., Baltimore, United States. In Cancer Biol Ther, 11 Apr 2014
An increasing body of evidence suggests crosstalk between ARID1A and PI3K/Akt pathways, and between ARID1A and p53.
CD44v6 Is a Marker of Constitutive and Reprogrammed Cancer Stem Cells Driving Colon Cancer Metastasis.
New
Impact
Stassi et al., Palermo, Italy. In Cell Stem Cell, 06 Apr 2014
Importantly, phosphatidylinositol 3-kinase (PI3K) inhibition selectively killed CD44v6 CR-CSCs and reduced metastatic growth.
Cholesteryl esters: fueling the fury of prostate cancer.
New
Impact
Schulze et al., London, United Kingdom. In Cell Metab, 04 Apr 2014
(2014) report that aberrant cholesteryl ester accumulation is found in advanced prostate cancers with PTEN loss and PI3K/AKT activation.
Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness.
New
Impact
Cheng et al., West Lafayette, United States. In Cell Metab, 04 Apr 2014
Biochemical study showed that such cholesteryl ester accumulation was a consequence of loss of tumor suppressor PTEN and subsequent activation of PI3K/AKT pathway in prostate cancer cells.
Crosstalk between hedgehog and other signaling pathways as a basis for combination therapies in cancer.
Review
New
Adjei et al., United States. In Cancer Treat Rev, 24 Mar 2014
Among such pathways, RAS/RAF/MEK/ERK, PI3K/AKT/mTOR, EGFR, and Notch are of particular interest because agents that selectively inhibit these pathways are available and can be readily combined with agents such as vismodegib, sonidegib (LDE225), and BMS-833923, which target smoothened-a key Hh pathway regulator.
Application of stem cell/growth factor system, as a multimodal therapy approach in regenerative medicine to improve cell therapy yields.
Review
New
Vakili Zarch et al., Yazd, Iran. In Int J Cardiol, 20 Mar 2014
Between them, there are some well known signaling pathways such as GF/GFR systems, SDF-1α/CXC4 ligand receptor interaction and PI3K/Akt signaling, and cytokines may regulate cell fate decisions, and can be utilized to positively influence cell therapy outcomes or accentuate synergistic compliance.
Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome.
New
Impact
Manning et al., Boston, United States. In Cell, 13 Mar 2014
Insulin activates mTORC1 through the PI3K-Akt pathway, which inhibits the TSC1-TSC2-TBC1D7 complex (the TSC complex) to turn on Rheb, an essential activator of mTORC1.
Wild-type h- and N-ras promote mutant k-ras-driven tumorigenesis by modulating the DNA damage response.
New
Impact
Bar-Sagi et al., New York City, United States. In Cancer Cell, 10 Mar 2014
Here, we show that downregulation of wild-type H-Ras or N-Ras in mutant K-Ras cancer cells leads to hyperactivation of the Erk/p90RSK and PI3K/Akt pathways and, consequently, the phosphorylation of Chk1 at an inhibitory site, Ser 280.
Phosphorylation of Akt Mediates Anti-Inflammatory Activity of 1-p-Coumaroyl β-D-Glucoside Against Lipopolysaccharide-Induced Inflammation in RAW264.7 Cells.
New
Chun et al., Ch'unch'ŏn, South Korea. In Korean J Physiol Pharmacol, 28 Feb 2014
Furthermore, inhibition of Akt/PI3K signaling pathway with wortmannin significantly, albeit not completely, abolished CG-induced Akt phosphorylation and anti-inflammatory actions.
Transcriptomic analysis of the effects of a fish oil enriched diet on murine brains.
New
Jett et al., United States. In Plos One, Dec 2013
FD potentially augmented the nervous system's development and functions by selectively stimulating the Src-mediated calcium-induced growth cascade and the downstream PI3K-AKT-PKC pathways.
PIK3CA in Colorectal Cancer.
Review
New
Cathomas, Switzerland. In Front Oncol, Dec 2013
UNLABELLED: PIK3CA, the catalytic subunit of PI3K, is mutated in many different tumors, including colorectal cancer (CRC).
OVA66, a Tumor Associated Protein, Induces Oncogenic Transformation of NIH3T3 Cells.
New
Ge et al., Shanghai, China. In Plos One, Dec 2013
Analysis of PI3K/AKT and ERK1/2 MAPK signaling pathways by serum stimulation indicated hyperactivation of AKT and ERK1/2 in NIH3T3-flagOVA66 cells compared with NIH3T3-mock cells, while a decreased level of p-AKT and p-ERK1/2 were observed in OVA66 knocked down HeLa cells.
Enhanced Insulin Sensitivity Associated with Provision of Mono and Polyunsaturated Fatty Acids in Skeletal Muscle Cells Involves Counter Modulation of PP2A.
New
Hundal et al., Dundee, United Kingdom. In Plos One, Dec 2013
This was not due to heightened upstream IRS1 or PI3K signalling nor to changes in expression of proteins involved in proximal insulin signalling, but was associated with reduced dephosphorylation/inactivation of Akt and ERK1/2.
Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy.
GeneRIF
Weinberger et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2012
PIK3CD shows evidence of association with schizophrenia, and is a previously undescribed therapeutic target for the treatment of psychiatric disorders.
The p110δ subunit of PI3K regulates bone marrow-derived eosinophil trafficking and airway eosinophilia in allergen-challenged mice.
GeneRIF
Sriramarao et al., Saint Paul, United States. In Am J Physiol Lung Cell Mol Physiol, 2012
PI3K p110delta mediates bone marrow-derived eosinophil trafficking and migration by regulating adhesion molecule expression and localization/distribution as well as promoting changes in cell morphology that favor recruitment during inflammation.
Attenuation of phosphoinositide 3-kinase δ signaling restrains autoimmune disease.
GeneRIF
Hibbs et al., Melbourne, Australia. In J Autoimmun, 2012
agents targeting p110delta PI3K need not achieve full blockade of the enzyme to be of great benefit in the treatment of Systemic lupus erythematosus (SLE).
PI3 kinase δ is a key regulator of synoviocyte function in rheumatoid arthritis.
GeneRIF
Firestein et al., San Diego, United States. In Am J Pathol, 2012
PI3 kinase delta is a key regulator of synoviocyte function in rheumatoid arthritis.
Genetic or pharmaceutical blockade of phosphoinositide 3-kinase p110δ prevents chronic rejection of heart allografts.
GeneRIF
Marelli-Berg et al., London, United Kingdom. In Plos One, 2011
Data suggest that targeting phosphoinositol-3-kinase p110delta activity might be a viable strategy for the treatment of heart chronic rejection.
More papers using p110delta antibodies
Nuclear factor-κB signaling: a contributor in leukemogenesis and a target for pharmacological intervention in human acute myelogenous leukemia
Supplier
Bruserud Øystein et al., In Bone Marrow Research, 2008
... The PI3K inhibitor 3-methyladenine (3-MA) and the specific IκB-kinase/NFκB inhibitor BMS-345541 were purchased from Sigma Aldrich (St ...
Non-Smad pathways in TGF-beta signaling
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Spessotto Paola et al., In The Journal of Cell Biology, 2008
... Ser465/467 and linker region Ser245/250/255), anti-Smad2/3, anti–phospho-Akt (Thr308 and Ser 473), anti-Akt, anti-PTEN, and anti–PI3K p110-α antibodies were obtained from Cell Signaling Technology ...
Autophagy fights disease through cellular self-digestion
Supplier
Wang Fen et al., In International Journal of Biological Sciences, 2007
... (Camarillo, CA), and PI3K (LY294002) was from Cell Signaling (Beverly, MA) ...
Optimization of Parameters for Semiempirical Methods V: Modification of NDDO Approximations and Application to 70 Elements
Supplier
Kuboyama Tomoharu et al., In Scientific Reports, 2006
... The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 (Cayman Chemicals), MEK1 inhibitor PD98059 ...
Transactivation and signaling functions of Tat are not correlated: biological and immunological characterization of HIV-1 subtype-C Tat protein.
Supplier
Kashanchi Fatah, In PLoS ONE, 2005
... (bFGF), epidermal growth factor (EGF), poly-D-lysine (PDL), Dulbecco's modified Eagle's medium (DMEM), morphine sulphate, specific PI3K inhibitor LY294002, etoposide and naloxone hydrochloride were all purchased from Sigma Aldrich (St ...
alpha-TEA inhibits survival and enhances death pathways in cisplatin sensitive and resistant human ovarian cancer cells
Supplier
Kline K et al., In British Journal of Cancer, 2005
... Map kinase kinase (MEK) inhibitor (U01260) and PI3K inhibitor (wortmannin) were purchased from Cell Signaling Technology (Beverly, MA, USA) ...
Src kinase regulation by phosphorylation and dephosphorylation
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Migliaccio Antimo, In PLoS ONE, 2004
... The Src inhibitor PP2, the EGFR inhibitor AG1478 and the PI3K inhibitor LY294002 were from Tocris Bioscience (Ellisville, MO) ...
FGF-23–Klotho signaling stimulates proliferation and prevents vitamin D–induced apoptosis
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Lanske Beate et al., In The Journal of Cell Biology, 2004
... Azam, Harvard Medical School, Boston, MA) and PI3K (LY294002; Cell Signaling Technology) inhibitors were added ...
Targeting I kappa B kinase for the treatment of inflammatory and other disorders
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Baharav Ehud et al., In Arthritis Research & Therapy, 2002
... AR and the signaling proteins PI3K, IKKα/β, were purchased from Santa Cruz Biotechnology Inc ...
Thioredoxin-mediated redox control of the transcription factor Sp1 and regulation of the thioredoxin gene promoter.
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Cordes Nils, In PLoS ONE, 2002
... The general PI3K inhibitor, LY294002, was from Cell Signaling Biotechnology ...
The biological action of saponins in animal systems: a review.
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Means Robert E., In PLoS ONE, 2001
... Antibodies against PI3K and phosphorylated PI3K were purchased from Cell Signaling Technology (Danvers, MA) ...
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
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Pesce Maurizio, In PLoS ONE, 2000
... Louis, MO, USA); the PI3K inhibitor LY294002 and the PAFR human polyclonal antibody from Cayman Chemical (Ann Arbor, Michigan, ...
A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube
Supplier
Farrar William L et al., In Molecular Cancer, 1999
... The following inhibitors were also used: Anti-human IL-6 antibody (R&D Systems, Minneapolis, MN), PI3K inhibitor LY294002 (Cell Signaling, Danvers, MA), Tec Kinase ...
The EGF receptor as central transducer of heterologous signalling systems.
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Hong Wanjin, In PLoS ONE, 1998
... The Src inhibitors PP2, the PI3K inhibitor LY294002, 4-hydoxy tamoxifen (4-OHT) and ICI 182, 780 were from Tocris Bioscience (Ellisville, MO) ...
Vav3 Modulates B Cell Receptor Responses by Regulating Phosphoinositide 3-Kinase Activation
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Kurosaki Tomohiro et al., In The Journal of Experimental Medicine, 1997
... purchased: anti-phosphotyrosine mAb (4G10), anti-Rac1 mAb, and rabbit anti-PI3K p85 Abs from Upstate Biotechnology, goat anti-PI3K p110α Abs (sc-1331) and goat anti-Akt1 Abs (sc-1618) from Santa Cruz Biotechnology, Inc., anti-c-Jun NH ...
Tumor necrosis factor-alpha in sera of obese patients: fall with weight loss
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Goalstone Marc L et al., In Journal of Inflammation (London, England), 1997
... Kinase inhibitors PD98059 (for MEK1/2) and Wortmannin (for PI3K) were from Cell Signaling (Danvers, MA) ...
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
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Cantrell Doreen et al., In The Journal of Cell Biology, 1995
... The PI3K inhibitor LY294002 was purchased from BIOMOL Research Laboratories, the histone ...
Positional cloning of the mouse obese gene and its human homologue
Supplier
Abdel-Aal Abeer Abdel-Alim et al., In Journal of Veterinary Science, 1993
... Wortmannin (WT; a PI3K inhibitor) was from Biomol Research Laboratories (USA) ...
Eosinophil transendothelial migration induced by cytokines. I. Role of endothelial and eosinophil adhesion molecules in IL-1 beta-induced transendothelial migration
Supplier
Heinemann Akos et al., In Cellular and Molecular Life Sciences, 1991
... The adenylyl cyclase inhibitor SQ22536, the PI3K inhibitor LY294002 and the PKC inhibitor chelerythrine were supplied from Biomol (Hamburg, Germany) ...
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
Supplier
Peppelenbosch M P et al., In Cell Death & Disease, 1991
... The PI3K inhibitor LY294002 was from Alexis (Läufelingen, Switzerland) and TNFα was from Biovision Inc ...
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
Supplier
Belkhiri Abbes, In PLoS ONE, 1989
... The PI3K siRNA kit was procured from Santa Cruz Biotechnology, Inc ...
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