Simultaneous determination of baicalin, baicalein, wogonin, berberine, palmatine and jatrorrhizine in rat plasma by liquid chromatography-tandem mass spectrometry and application in pharmacokinetic studies after oral administration of traditional Chinese medicinal preparations containing scutellaria-coptis herb couplemore suppliers
In Evidence-based Complementary and Alternative Medicine : eCAM, 2009
... RIPA buffer and PI3K inhibitor, LY294002, were obtained from Millipore (Billerica, MA, USA) and Cell Signaling (Danver, MA, USA), respectively ...
Natural Products That Target Cancer Stem Cells.
Louisville, United States. In Anticancer Res, 30 Nov 2015
The Wingless/Integrated (WNT), Hedgehog, Notch and PI3K/AKT/mTOR pathways have all been associated with quiescence and self-renewal of CSCs, as well as execution of CSC function including differentiation, multidrug resistance and metastasis.
Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase Signaling in B Cells.
Boston, United States. In Immunity, 20 Nov 2015
Furthermore, in the absence of WIP, several receptors, namely the BCR, BAFFR, CXCR4, CXCR5, CD40, and TLR4, were impaired in promoting CD19 co-receptor activation and subsequent PI3 kinase (PI3K) signaling.
Tribbles in inflammation.
Sheffield, United Kingdom. In Biochem Soc Trans, 01 Nov 2015
The tribbles (TRIB) family of pseudokinase proteins has been shown to modulate key inflammatory signalling pathways, including the MAPK (mitogen-activated protein kinase) and PI3K (phosphoinositide 3-kinase) networks.
Signalling to eIF4E in cancer.
Montréal, Canada. In Biochem Soc Trans, 01 Nov 2015
The activity of eIF4E is regulated at many levels, most profoundly by two major signalling pathways: PI3K (phosphoinositide 3-kinase)/Akt (also known and Protein Kinase B, PKB)/mTOR (mechanistic/mammalian target of rapamycin) and Ras (rat sarcoma)/MAPK (mitogen-activated protein kinase)/Mnk (MAPK-interacting kinases).
Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA): a multicentre, open-label, proof-of-concept, randomised, controlled phase 2 trial.
Saint-Cloud, France. In Lancet Oncol, 31 Oct 2015
We only included patients for whom a molecular alteration was identified within one of three molecular pathways (hormone receptor, PI3K/AKT/mTOR, RAF/MEK), which could be matched to one of ten regimens including 11 available molecularly targeted agents (erlotinib, lapatinib plus trastuzumab, sorafenib, imatinib, dasatinib, vemurafenib, everolimus, abiraterone, letrozole, tamoxifen).
Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway.
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San Francisco, United States. In Nat Genet, 31 Oct 2015
Instead, other genetic alterations known to activate the MAPK and PI3K signaling cascades were identified in 73% of samples, affecting NF1, CBL, ERBB2, MAP2K1, MAP3K1, BRAF, EGFR, PTPN11, MET, RAC1, SOS2, NRAS and PIK3CA, some of which are candidates for targeted therapies.
Non-Smad pathways in TGF-beta signaling
In The Journal of Cell Biology, 2008
... Ser465/467 and linker region Ser245/250/255), anti-Smad2/3, anti–phospho-Akt (Thr308 and Ser 473), anti-Akt, anti-PTEN, and anti–PI3K p110-α antibodies were obtained from Cell Signaling Technology ...