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Phosphatidylinositol 3-kinase catalytic delta polypeptide

p110delta, PI3K
Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: PI3K, Akt, V1a, mTOR, CAN
Papers using p110delta antibodies
Signal transducer and activator of transcription 3 (STAT3) and Suppressor of Cytokine Signaling (SOCS3) balance controls cytotoxicity and IL-10 expression in decidual-like natural killer cell line NK-92
Jacobs Roland, In PLoS ONE, 2010
... phospho-MAPKp44/42, anti-human SOCS3, anti-human phosphor-STAT3 antibodies, the U0126 (inhibitor of ERK1/2) and wortmannin (inhibitor of PI3K) were obtained from Cell Signaling Technology (Boston, MA, USA) ...
Decreased Level of PDCD4 (Programmed Cell Death 4) Protein Activated Cell Proliferation in the Lung of A/J Mouse.
Hotchin Neil A., In PLoS ONE, 2009
... Phosphoinositide 3-kinase (PI3K) inhibitor LY294002 (Cell Signaling Technology Inc., Danvers, MA), ...
Simultaneous determination of baicalin, baicalein, wogonin, berberine, palmatine and jatrorrhizine in rat plasma by liquid chromatography-tandem mass spectrometry and application in pharmacokinetic studies after oral administration of traditional Chinese medicinal preparations containing scutellaria-coptis herb couple
Ma Jin Yeul et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2009
... RIPA buffer and PI3K inhibitor, LY294002, were obtained from Millipore (Billerica, MA, USA) and Cell Signaling (Danver, MA, USA), respectively ...
Age- and diet-specific effects of variation at S6 kinase on life history, metabolic, and immune response traits in Drosophila melanogaster.
Harrison Jeffrey K., In PLoS ONE, 2009
... Phospho-S270 of IRS-1 and PI3k-p85a antibody were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Estrogen receptor-alpha (ER-alpha) suppresses expression of its variant ER-alpha 36
Wang Zhao-Yi et al., In Oncogene, 2008
... The MEK1/2 inhibitor U0126, the Src inhibitor PP2, and the PI3K inhibitor LY294002 were from Tocris Bioscience (Ellisville, MO) ...
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Papers on p110delta
The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias.
St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project et al., Memphis, United States. In Nat Genet, 30 Apr 2015
Despite this paucity of mutations, we detected activating mutations in kinase-PI3K-RAS signaling pathway components in 47% of cases.
Molecular classification of gastric adenocarcinoma: translating new insights from the cancer genome atlas research network.
Lenz et al., Los Angeles, United States. In Curr Treat Options Oncol, 30 Apr 2015
According to TCGA study, EBV gastric cancer patients may benefit the programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) antibodies or phosphoinositide 3-kinase (PI3K) inhibitors which are now being developed.
Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity.
Rodeheffer et al., New Haven, United States. In Nat Cell Biol, 30 Apr 2015
Furthermore, we find that in multiple models of obesity, the activation of APs is dependent on the phosphoinositide 3-kinase (PI3K)-AKT2 pathway; however, the development of WAT does not require AKT2.
Two paths to fat.
Rosen, Boston, United States. In Nat Cell Biol, 27 Apr 2015
New findings show that PI3K-Akt2 signalling is involved in the differentiation of adult adipose precursor cells - a pathway not required for adipogenesis in the embryo.
Transforming growth factor type-β inhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes; Relevance to fibrosis associated to muscular dystrophies.
Brandan et al., Santiago, Chile. In Biofactors, 23 Apr 2015
This inhibition was mediated by the Smad-dependent (canonical) and the PI3K and MEK1/2 (noncanonical) TGF-β signaling pathways.
[New therapeutical strategies in metastatic hormone-dependent breast cancer].
Heudel et al., Montpellier, France. In Bull Cancer, 20 Apr 2015
In this review, we will discuss the development of strategies targeting the PI3K/Akt/mTOR pathway, CDK4/6 (Cyclin Dependent Kinase 4/6) and FGFR (Fibroblast Growth Factor Receptor) in hormone-dependent metastatic breast cancer (ER+).
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
Cohen et al., Bethesda, United States. In Virology, 19 Apr 2015
UNASSIGNED: The phosphatidylinositol-3-kinase (PI3K)-Akt signaling pathway regulates several key cellular functions including protein synthesis, cell growth, glucose metabolism, and inflammation.
Local Triggering of the ICOS Coreceptor by CD11c(+) Myeloid Cells Drives Organ Inflammation in Lupus.
Shlomchik et al., Bonn, Germany. In Immunity, 17 Apr 2015
However, ICOSL display by CD11c(+) cells in inflamed organs had a nonredundant role in protecting invading T cells from apoptosis by elevating activity of the PI3K-Akt signaling pathway, thereby facilitating T cell accrual.
Everolimus Plus Exemestane for the Treatment of Advanced Breast Cancer: A Review of Subanalyses from BOLERO-2.
Hortobagyi, Houston, United States. In Neoplasia, 31 Mar 2015
Phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway aberrations are common in breast cancer, with increased PI3K/AKT/mTOR signaling associated with resistance to endocrine and human epidermal growth factor receptor 2 (HER2)-targeted therapies.
Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids.
Sato et al., Tokyo, Japan. In Nat Med, 31 Mar 2015
Human colorectal tumors bear recurrent mutations in genes encoding proteins operative in the WNT, MAPK, TGF-β, TP53 and PI3K pathways.
Myocyte enhancer factor (MEF)-2 plays essential roles in T-cell transformation associated with HTLV-1 infection by stabilizing complex between Tax and CREB.
Khan et al., In Retrovirology, Dec 2014
MEF-2-integrated signaling pathways (PI3K/Akt, NF-κB, MAPK, JAK/STAT, and TGF-β) were also activated during HTLV-1 infection of primary CD4+ T cells, possibly regulating MEF-2 activity.
Interplay between glucose and leptin signalling determines the strength of GABAergic synapses at POMC neurons.
Jo et al., New York City, United States. In Nat Commun, Dec 2014
Leptin stimulates the JAK2-PI3K pathway in both presynaptic GABAergic terminals and postsynaptic POMC neurons.
[Molecular alterations in melanoma and targeted therapies].
Lebbé et al., Paris, France. In Bull Cancer, Dec 2014
Several signaling pathways are involved in the progression of this disease with oncogenic mutations affecting signaling pathways: MAPK, PI3K, cAMP and cyclin D1/CDK4.
Current management approach to hidradenocarcinoma: a comprehensive review of the literature.
Chauhan et al., Rohtak, India. In Ecancermedicalscience, Dec 2014
Other treatment strategies are targeted therapies like trastuzumab, EGFR inhibitors, PI3K/Akt/mTOR pathway inhibitors, hormonal agents like antiandrogens, electrochemotherapy, or clinical trials.
Predicting resistance by selection of signaling pathways.
Viteri et al., Barcelona, Spain. In Transl Lung Cancer Res, Apr 2014
SHP2 is essential to the balance between ERK and the phosphoinositide-3-kinase (PI3K)/AKT and signal transducer activator of transcription (STAT) activity, while mTOR can be an additional marker for patients with high BIM expression.
Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy.
Weinberger et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2012
PIK3CD shows evidence of association with schizophrenia, and is a previously undescribed therapeutic target for the treatment of psychiatric disorders.
The p110δ subunit of PI3K regulates bone marrow-derived eosinophil trafficking and airway eosinophilia in allergen-challenged mice.
Sriramarao et al., Saint Paul, United States. In Am J Physiol Lung Cell Mol Physiol, 2012
PI3K p110delta mediates bone marrow-derived eosinophil trafficking and migration by regulating adhesion molecule expression and localization/distribution as well as promoting changes in cell morphology that favor recruitment during inflammation.
Attenuation of phosphoinositide 3-kinase δ signaling restrains autoimmune disease.
Hibbs et al., Melbourne, Australia. In J Autoimmun, 2012
agents targeting p110delta PI3K need not achieve full blockade of the enzyme to be of great benefit in the treatment of Systemic lupus erythematosus (SLE).
PI3 kinase δ is a key regulator of synoviocyte function in rheumatoid arthritis.
Firestein et al., San Diego, United States. In Am J Pathol, 2012
PI3 kinase delta is a key regulator of synoviocyte function in rheumatoid arthritis.
Genetic or pharmaceutical blockade of phosphoinositide 3-kinase p110δ prevents chronic rejection of heart allografts.
Marelli-Berg et al., London, United Kingdom. In Plos One, 2011
Data suggest that targeting phosphoinositol-3-kinase p110delta activity might be a viable strategy for the treatment of heart chronic rejection.
More papers using p110delta antibodies
Nuclear factor-κB signaling: a contributor in leukemogenesis and a target for pharmacological intervention in human acute myelogenous leukemia
Bruserud Øystein et al., In Bone Marrow Research, 2008
... The PI3K inhibitor 3-methyladenine (3-MA) and the specific IκB-kinase/NFκB inhibitor BMS-345541 were purchased from Sigma Aldrich (St ...
Non-Smad pathways in TGF-beta signaling
Spessotto Paola et al., In The Journal of Cell Biology, 2008
... Ser465/467 and linker region Ser245/250/255), anti-Smad2/3, anti–phospho-Akt (Thr308 and Ser 473), anti-Akt, anti-PTEN, and anti–PI3K p110-α antibodies were obtained from Cell Signaling Technology ...
Autophagy fights disease through cellular self-digestion
Wang Fen et al., In International Journal of Biological Sciences, 2007
... (Camarillo, CA), and PI3K (LY294002) was from Cell Signaling (Beverly, MA) ...
Optimization of Parameters for Semiempirical Methods V: Modification of NDDO Approximations and Application to 70 Elements
Kuboyama Tomoharu et al., In Scientific Reports, 2006
... The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 (Cayman Chemicals), MEK1 inhibitor PD98059 ...
Transactivation and signaling functions of Tat are not correlated: biological and immunological characterization of HIV-1 subtype-C Tat protein.
Kashanchi Fatah, In PLoS ONE, 2005
... (bFGF), epidermal growth factor (EGF), poly-D-lysine (PDL), Dulbecco's modified Eagle's medium (DMEM), morphine sulphate, specific PI3K inhibitor LY294002, etoposide and naloxone hydrochloride were all purchased from Sigma Aldrich (St ...
alpha-TEA inhibits survival and enhances death pathways in cisplatin sensitive and resistant human ovarian cancer cells
Kline K et al., In British Journal of Cancer, 2005
... Map kinase kinase (MEK) inhibitor (U01260) and PI3K inhibitor (wortmannin) were purchased from Cell Signaling Technology (Beverly, MA, USA) ...
Src kinase regulation by phosphorylation and dephosphorylation
Migliaccio Antimo, In PLoS ONE, 2004
... The Src inhibitor PP2, the EGFR inhibitor AG1478 and the PI3K inhibitor LY294002 were from Tocris Bioscience (Ellisville, MO) ...
FGF-23–Klotho signaling stimulates proliferation and prevents vitamin D–induced apoptosis
Lanske Beate et al., In The Journal of Cell Biology, 2004
... Azam, Harvard Medical School, Boston, MA) and PI3K (LY294002; Cell Signaling Technology) inhibitors were added ...
Targeting I kappa B kinase for the treatment of inflammatory and other disorders
Baharav Ehud et al., In Arthritis Research & Therapy, 2002
... AR and the signaling proteins PI3K, IKKα/β, were purchased from Santa Cruz Biotechnology Inc ...
Thioredoxin-mediated redox control of the transcription factor Sp1 and regulation of the thioredoxin gene promoter.
Cordes Nils, In PLoS ONE, 2002
... The general PI3K inhibitor, LY294002, was from Cell Signaling Biotechnology ...
The biological action of saponins in animal systems: a review.
Means Robert E., In PLoS ONE, 2001
... Antibodies against PI3K and phosphorylated PI3K were purchased from Cell Signaling Technology (Danvers, MA) ...
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
Pesce Maurizio, In PLoS ONE, 2000
... Louis, MO, USA); the PI3K inhibitor LY294002 and the PAFR human polyclonal antibody from Cayman Chemical (Ann Arbor, Michigan, ...
A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube
Farrar William L et al., In Molecular Cancer, 1999
... The following inhibitors were also used: Anti-human IL-6 antibody (R&D Systems, Minneapolis, MN), PI3K inhibitor LY294002 (Cell Signaling, Danvers, MA), Tec Kinase ...
The EGF receptor as central transducer of heterologous signalling systems.
Hong Wanjin, In PLoS ONE, 1998
... The Src inhibitors PP2, the PI3K inhibitor LY294002, 4-hydoxy tamoxifen (4-OHT) and ICI 182, 780 were from Tocris Bioscience (Ellisville, MO) ...
Vav3 Modulates B Cell Receptor Responses by Regulating Phosphoinositide 3-Kinase Activation
Kurosaki Tomohiro et al., In The Journal of Experimental Medicine, 1997
... purchased: anti-phosphotyrosine mAb (4G10), anti-Rac1 mAb, and rabbit anti-PI3K p85 Abs from Upstate Biotechnology, goat anti-PI3K p110α Abs (sc-1331) and goat anti-Akt1 Abs (sc-1618) from Santa Cruz Biotechnology, Inc., anti-c-Jun NH ...
Tumor necrosis factor-alpha in sera of obese patients: fall with weight loss
Goalstone Marc L et al., In Journal of Inflammation (London, England), 1997
... Kinase inhibitors PD98059 (for MEK1/2) and Wortmannin (for PI3K) were from Cell Signaling (Danvers, MA) ...
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
Cantrell Doreen et al., In The Journal of Cell Biology, 1995
... The PI3K inhibitor LY294002 was purchased from BIOMOL Research Laboratories, the histone ...
Positional cloning of the mouse obese gene and its human homologue
Abdel-Aal Abeer Abdel-Alim et al., In Journal of Veterinary Science, 1993
... Wortmannin (WT; a PI3K inhibitor) was from Biomol Research Laboratories (USA) ...
Eosinophil transendothelial migration induced by cytokines. I. Role of endothelial and eosinophil adhesion molecules in IL-1 beta-induced transendothelial migration
Heinemann Akos et al., In Cellular and Molecular Life Sciences, 1991
... The adenylyl cyclase inhibitor SQ22536, the PI3K inhibitor LY294002 and the PKC inhibitor chelerythrine were supplied from Biomol (Hamburg, Germany) ...
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
Peppelenbosch M P et al., In Cell Death & Disease, 1991
... The PI3K inhibitor LY294002 was from Alexis (Läufelingen, Switzerland) and TNFα was from Biovision Inc ...
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
Belkhiri Abbes, In PLoS ONE, 1989
... The PI3K siRNA kit was procured from Santa Cruz Biotechnology, Inc ...
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