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Phosphatidylinositol 3-kinase catalytic delta polypeptide

p110delta, PI3K
Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: PI3K, Akt, V1a, mTOR, CAN
Papers using p110delta antibodies
Signal transducer and activator of transcription 3 (STAT3) and Suppressor of Cytokine Signaling (SOCS3) balance controls cytotoxicity and IL-10 expression in decidual-like natural killer cell line NK-92
Supplier
Jacobs Roland, In PLoS ONE, 2010
... phospho-MAPKp44/42, anti-human SOCS3, anti-human phosphor-STAT3 antibodies, the U0126 (inhibitor of ERK1/2) and wortmannin (inhibitor of PI3K) were obtained from Cell Signaling Technology (Boston, MA, USA) ...
Decreased Level of PDCD4 (Programmed Cell Death 4) Protein Activated Cell Proliferation in the Lung of A/J Mouse.
Supplier
Hotchin Neil A., In PLoS ONE, 2009
... Phosphoinositide 3-kinase (PI3K) inhibitor LY294002 (Cell Signaling Technology Inc., Danvers, MA), ...
Simultaneous determination of baicalin, baicalein, wogonin, berberine, palmatine and jatrorrhizine in rat plasma by liquid chromatography-tandem mass spectrometry and application in pharmacokinetic studies after oral administration of traditional Chinese medicinal preparations containing scutellaria-coptis herb couple
Supplier
Ma Jin Yeul et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2009
... RIPA buffer and PI3K inhibitor, LY294002, were obtained from Millipore (Billerica, MA, USA) and Cell Signaling (Danver, MA, USA), respectively ...
Age- and diet-specific effects of variation at S6 kinase on life history, metabolic, and immune response traits in Drosophila melanogaster.
Supplier
Harrison Jeffrey K., In PLoS ONE, 2009
... Phospho-S270 of IRS-1 and PI3k-p85a antibody were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Estrogen receptor-alpha (ER-alpha) suppresses expression of its variant ER-alpha 36
Supplier
Wang Zhao-Yi et al., In Oncogene, 2008
... The MEK1/2 inhibitor U0126, the Src inhibitor PP2, and the PI3K inhibitor LY294002 were from Tocris Bioscience (Ellisville, MO) ...
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Papers on p110delta
Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration.
New
Samelson et al., Bethesda, United States. In Eur J Immunol, 14 Jun 2015
Activation of AKT was likely a consequence of increased recruitment of PI3K to Grb2 upon TCR and/or IL-2 stimulation in Sos-1/2dKO CD4(+) T cells.
Electroacupuncture with high frequency at acupoint ST-36 induces regeneration of lost enteric neurons in diabetic rats via GDNF and PI3k/Akt signal pathway.
New
Liu et al., Union, United States. In Am J Physiol Regul Integr Comp Physiol, 13 Jun 2015
Conclusions EA with high frequency and long-term stimuli at acupoint ST-36 can induce regeneration of lost enteric neurons in diabetic rats, GDNF and PI3K/Akt signal pathway may play an important role in EA induced regeneration of impaired enteric neurons.
Decreased affinity for efflux transporters increases brain penetrance and molecular targeting of a PI3K/mTOR inhibitor in a mouse model of glioblastoma.
New
Elmquist et al., Minneapolis, United States. In Neuro Oncol, 12 Jun 2015
To test the hypothesis that efflux transporters influence brain pharmacokinetics/pharmacodynamics of molecularly targeted agents in glioma treatment, we assessed region-specific penetrance and molecular-targeting capacity for a PI3K/mTOR kinase inhibitor that has high substrate affinity for efflux transporters (GDC-0980) and an analog (GNE-317) that was purposely designed to have reduced efflux.
A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis.
New
Impact
Largaespada et al., Minneapolis, United States. In Nat Genet, 11 Jun 2015
Analysis of CIS-associated genes identified numerous known and new osteosarcoma-associated genes enriched in the ErbB, PI3K-AKT-mTOR and MAPK signaling pathways.
Translational potential of cancer stem cells: A review of the detection of cancer stem cells and their roles in Cancer recurrence and cancer treatment.
Review
New
Lam et al., Gold Coast, Australia. In Exp Cell Res, 09 Jun 2015
The other important contributing factor for CSCs in cancer management is their function in causing treatment resistance and recurrence in cancer via their activation of different signaling pathways such as Notch, Wnt/β-catenin, TGF-β, Hedgehog, PI3K/Akt/mTOR and JAK/STAT pathways.
Preclinical and clinical studies of the NEDD9 scaffold protein in cancer and other diseases.
Review
New
Golemis et al., Philadelphia, United States. In Gene, 09 Jun 2015
Downstream, NEDD9 regulation of partners including CRKL, WAVE, PI3K/AKT, ERK, E-cadherin, Aurora-A (AURKA), HDAC6, and others allow NEDD9 to influence functions as pleiotropic as migration, invasion, survival, ciliary resorption, and mitosis.
Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion.
New
Impact
Monje et al., Stanford, United States. In Cell, 07 Jun 2015
NLGN3 induced PI3K-mTOR pathway activity and feedforward expression of NLGN3 in glioma cells.
Cardioprotection by gene therapy: A review paper on behalf of the Working Group on Drug Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology.
Review
New
Ferdinandy et al., Chieti, Italy. In Int J Cardiol, 01 Jun 2015
Genes critical for signaling pathways in cardioprotection include protectomiRs (e.g., microRNA 125b*), ZAC1 transcription factor, pro-inflammatory genes such as cycloxygenase (COX)-2 and inducible nitric oxide synthase (iNOS), antioxidant enzymes such as hemoxygenase (HO)-1, extracellular and manganese superoxidase dismutases (ec-SOD and Mg-SOD), heat shock proteins (HSPs), growth factors such as insulin like growth factor (IGF)-1 and hepatocyte growth factor (HGF), antiapoptotic proteins such as Bcl-2 and Bcl-xL, pro-apoptotic proteins such as FasL, Bcl-2, Bax, caspase-3 and p53, and proangiogenic genes such as TGFbeta, sphingosine kinase 1 (SPK1), and PI3K-Akt.
Transposon mutagenesis identifies genetic drivers of Braf(V600E) melanoma.
New
Impact
Jenkins et al., Houston, United States. In Nat Genet, 31 May 2015
CCGs are enriched in Wnt, PI3K, MAPK and netrin signaling pathway components and are more highly connected to one another than predicted by chance, indicating that SB targets cooperative genetic networks in melanoma.
Structural and functional characterization of NRF2 degradation By glycogen synthase kinase 3/β-TrCP.
Review
New
Cuadrado, Madrid, Spain. In Free Radic Biol Med, 29 May 2015
These pathways include those activated by ligands of tyrosine kinase, G protein coupled, metabotropic and ionotropic receptors that activate phosphatidyl inositol 3-kinase (PI3K)/ATK and by the canonical WNT signaling pathway where a fraction of NRF2 interacts with Axin1/GSK-3.
AXL Mediates Resistance to PI3Kα Inhibition by Activating the EGFR/PKC/mTOR Axis in Head and Neck and Esophageal Squamous Cell Carcinomas.
New
Impact
Baselga et al., New York City, United States. In Cancer Cell, 13 May 2015
Phosphoinositide-3-kinase (PI3K)-α inhibitors have shown clinical activity in squamous cell carcinomas (SCCs) of head and neck (H&N) bearing PIK3CA mutations or amplification.
Pharmacological Inhibition of PI3K Reduces Adiposity and Metabolic Syndrome in Obese Mice and Rhesus Monkeys.
New
Impact
Serrano et al., Madrid, Spain. In Cell Metab, 07 May 2015
Genetic inhibition of PI3K signaling increases energy expenditure, protects from obesity and metabolic syndrome, and extends longevity.
Sphingomyelinase D/Ceramide 1-Phosphate in Cell Survival and Inflammation.
Review
New
Gomez-Muñoz et al., Bilbao, Spain. In Toxins (basel), Dec 2014
The C1P receptor is coupled to Gi proteins and activates of the PI3K/Akt and MEK/ERK1-2 pathways upon ligation with C1P.
Marine lipopeptide Iturin A inhibits Akt mediated GSK3β and FoxO3a signaling and triggers apoptosis in breast cancer.
New
Mandal et al., Kharagpur, India. In Sci Rep, Dec 2014
UNASSIGNED: Akt kinase is a critical component of the PI3K/Akt signaling pathway, which is frequently over expressed in human cancers including breast.
House Dust Mite Allergen Regulates Constitutive Apoptosis of Normal and Asthmatic Neutrophils via Toll-Like Receptor 4.
New
Kim et al., Taejŏn, South Korea. In Plos One, Dec 2014
Anti-apoptotic signaling mediated by DP involves in TLR4, Lyn, PI3K, Akt, ERK, and NF-κB in normal neutrophils.
Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy.
GeneRIF
Weinberger et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2012
PIK3CD shows evidence of association with schizophrenia, and is a previously undescribed therapeutic target for the treatment of psychiatric disorders.
The p110δ subunit of PI3K regulates bone marrow-derived eosinophil trafficking and airway eosinophilia in allergen-challenged mice.
GeneRIF
Sriramarao et al., Saint Paul, United States. In Am J Physiol Lung Cell Mol Physiol, 2012
PI3K p110delta mediates bone marrow-derived eosinophil trafficking and migration by regulating adhesion molecule expression and localization/distribution as well as promoting changes in cell morphology that favor recruitment during inflammation.
Attenuation of phosphoinositide 3-kinase δ signaling restrains autoimmune disease.
GeneRIF
Hibbs et al., Melbourne, Australia. In J Autoimmun, 2012
agents targeting p110delta PI3K need not achieve full blockade of the enzyme to be of great benefit in the treatment of Systemic lupus erythematosus (SLE).
PI3 kinase δ is a key regulator of synoviocyte function in rheumatoid arthritis.
GeneRIF
Firestein et al., San Diego, United States. In Am J Pathol, 2012
PI3 kinase delta is a key regulator of synoviocyte function in rheumatoid arthritis.
Genetic or pharmaceutical blockade of phosphoinositide 3-kinase p110δ prevents chronic rejection of heart allografts.
GeneRIF
Marelli-Berg et al., London, United Kingdom. In Plos One, 2011
Data suggest that targeting phosphoinositol-3-kinase p110delta activity might be a viable strategy for the treatment of heart chronic rejection.
More papers using p110delta antibodies
Nuclear factor-κB signaling: a contributor in leukemogenesis and a target for pharmacological intervention in human acute myelogenous leukemia
Supplier
Bruserud Øystein et al., In Bone Marrow Research, 2008
... The PI3K inhibitor 3-methyladenine (3-MA) and the specific IκB-kinase/NFκB inhibitor BMS-345541 were purchased from Sigma Aldrich (St ...
Non-Smad pathways in TGF-beta signaling
Supplier
Spessotto Paola et al., In The Journal of Cell Biology, 2008
... Ser465/467 and linker region Ser245/250/255), anti-Smad2/3, anti–phospho-Akt (Thr308 and Ser 473), anti-Akt, anti-PTEN, and anti–PI3K p110-α antibodies were obtained from Cell Signaling Technology ...
Autophagy fights disease through cellular self-digestion
Supplier
Wang Fen et al., In International Journal of Biological Sciences, 2007
... (Camarillo, CA), and PI3K (LY294002) was from Cell Signaling (Beverly, MA) ...
Optimization of Parameters for Semiempirical Methods V: Modification of NDDO Approximations and Application to 70 Elements
Supplier
Kuboyama Tomoharu et al., In Scientific Reports, 2006
... The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 (Cayman Chemicals), MEK1 inhibitor PD98059 ...
Transactivation and signaling functions of Tat are not correlated: biological and immunological characterization of HIV-1 subtype-C Tat protein.
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Kashanchi Fatah, In PLoS ONE, 2005
... (bFGF), epidermal growth factor (EGF), poly-D-lysine (PDL), Dulbecco's modified Eagle's medium (DMEM), morphine sulphate, specific PI3K inhibitor LY294002, etoposide and naloxone hydrochloride were all purchased from Sigma Aldrich (St ...
alpha-TEA inhibits survival and enhances death pathways in cisplatin sensitive and resistant human ovarian cancer cells
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Kline K et al., In British Journal of Cancer, 2005
... Map kinase kinase (MEK) inhibitor (U01260) and PI3K inhibitor (wortmannin) were purchased from Cell Signaling Technology (Beverly, MA, USA) ...
Src kinase regulation by phosphorylation and dephosphorylation
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Migliaccio Antimo, In PLoS ONE, 2004
... The Src inhibitor PP2, the EGFR inhibitor AG1478 and the PI3K inhibitor LY294002 were from Tocris Bioscience (Ellisville, MO) ...
FGF-23–Klotho signaling stimulates proliferation and prevents vitamin D–induced apoptosis
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Lanske Beate et al., In The Journal of Cell Biology, 2004
... Azam, Harvard Medical School, Boston, MA) and PI3K (LY294002; Cell Signaling Technology) inhibitors were added ...
Targeting I kappa B kinase for the treatment of inflammatory and other disorders
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Baharav Ehud et al., In Arthritis Research & Therapy, 2002
... AR and the signaling proteins PI3K, IKKα/β, were purchased from Santa Cruz Biotechnology Inc ...
Thioredoxin-mediated redox control of the transcription factor Sp1 and regulation of the thioredoxin gene promoter.
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Cordes Nils, In PLoS ONE, 2002
... The general PI3K inhibitor, LY294002, was from Cell Signaling Biotechnology ...
The biological action of saponins in animal systems: a review.
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Means Robert E., In PLoS ONE, 2001
... Antibodies against PI3K and phosphorylated PI3K were purchased from Cell Signaling Technology (Danvers, MA) ...
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
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Pesce Maurizio, In PLoS ONE, 2000
... Louis, MO, USA); the PI3K inhibitor LY294002 and the PAFR human polyclonal antibody from Cayman Chemical (Ann Arbor, Michigan, ...
A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube
Supplier
Farrar William L et al., In Molecular Cancer, 1999
... The following inhibitors were also used: Anti-human IL-6 antibody (R&D Systems, Minneapolis, MN), PI3K inhibitor LY294002 (Cell Signaling, Danvers, MA), Tec Kinase ...
The EGF receptor as central transducer of heterologous signalling systems.
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Hong Wanjin, In PLoS ONE, 1998
... The Src inhibitors PP2, the PI3K inhibitor LY294002, 4-hydoxy tamoxifen (4-OHT) and ICI 182, 780 were from Tocris Bioscience (Ellisville, MO) ...
Vav3 Modulates B Cell Receptor Responses by Regulating Phosphoinositide 3-Kinase Activation
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Kurosaki Tomohiro et al., In The Journal of Experimental Medicine, 1997
... purchased: anti-phosphotyrosine mAb (4G10), anti-Rac1 mAb, and rabbit anti-PI3K p85 Abs from Upstate Biotechnology, goat anti-PI3K p110α Abs (sc-1331) and goat anti-Akt1 Abs (sc-1618) from Santa Cruz Biotechnology, Inc., anti-c-Jun NH ...
Tumor necrosis factor-alpha in sera of obese patients: fall with weight loss
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Goalstone Marc L et al., In Journal of Inflammation (London, England), 1997
... Kinase inhibitors PD98059 (for MEK1/2) and Wortmannin (for PI3K) were from Cell Signaling (Danvers, MA) ...
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
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Cantrell Doreen et al., In The Journal of Cell Biology, 1995
... The PI3K inhibitor LY294002 was purchased from BIOMOL Research Laboratories, the histone ...
Positional cloning of the mouse obese gene and its human homologue
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Abdel-Aal Abeer Abdel-Alim et al., In Journal of Veterinary Science, 1993
... Wortmannin (WT; a PI3K inhibitor) was from Biomol Research Laboratories (USA) ...
Eosinophil transendothelial migration induced by cytokines. I. Role of endothelial and eosinophil adhesion molecules in IL-1 beta-induced transendothelial migration
Supplier
Heinemann Akos et al., In Cellular and Molecular Life Sciences, 1991
... The adenylyl cyclase inhibitor SQ22536, the PI3K inhibitor LY294002 and the PKC inhibitor chelerythrine were supplied from Biomol (Hamburg, Germany) ...
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
Supplier
Peppelenbosch M P et al., In Cell Death & Disease, 1991
... The PI3K inhibitor LY294002 was from Alexis (Läufelingen, Switzerland) and TNFα was from Biovision Inc ...
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
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Belkhiri Abbes, In PLoS ONE, 1989
... The PI3K siRNA kit was procured from Santa Cruz Biotechnology, Inc ...
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