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Phosphatidylinositol 3-kinase catalytic delta polypeptide

p110delta, PI3K
Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: PI3K, Akt, V1a, mTOR, CAN
Papers using p110delta antibodies
Signal transducer and activator of transcription 3 (STAT3) and Suppressor of Cytokine Signaling (SOCS3) balance controls cytotoxicity and IL-10 expression in decidual-like natural killer cell line NK-92
Jacobs Roland, In PLoS ONE, 2010
... phospho-MAPKp44/42, anti-human SOCS3, anti-human phosphor-STAT3 antibodies, the U0126 (inhibitor of ERK1/2) and wortmannin (inhibitor of PI3K) were obtained from Cell Signaling Technology (Boston, MA, USA) ...
Decreased Level of PDCD4 (Programmed Cell Death 4) Protein Activated Cell Proliferation in the Lung of A/J Mouse.
Hotchin Neil A., In PLoS ONE, 2009
... Phosphoinositide 3-kinase (PI3K) inhibitor LY294002 (Cell Signaling Technology Inc., Danvers, MA), ...
Simultaneous determination of baicalin, baicalein, wogonin, berberine, palmatine and jatrorrhizine in rat plasma by liquid chromatography-tandem mass spectrometry and application in pharmacokinetic studies after oral administration of traditional Chinese medicinal preparations containing scutellaria-coptis herb couple
Ma Jin Yeul et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2009
... RIPA buffer and PI3K inhibitor, LY294002, were obtained from Millipore (Billerica, MA, USA) and Cell Signaling (Danver, MA, USA), respectively ...
Age- and diet-specific effects of variation at S6 kinase on life history, metabolic, and immune response traits in Drosophila melanogaster.
Harrison Jeffrey K., In PLoS ONE, 2009
... Phospho-S270 of IRS-1 and PI3k-p85a antibody were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Estrogen receptor-alpha (ER-alpha) suppresses expression of its variant ER-alpha 36
Wang Zhao-Yi et al., In Oncogene, 2008
... The MEK1/2 inhibitor U0126, the Src inhibitor PP2, and the PI3K inhibitor LY294002 were from Tocris Bioscience (Ellisville, MO) ...
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Papers on p110delta
Endothelin-1 Induces VCAM-1 Expression-Mediated Inflammation via Receptor Tyrosine Kinases and Elk/p300 in Human Tracheal Smooth Muscle Cells.
Yang et al., Dschang, Cameroon. In Am J Physiol Lung Cell Mol Physiol, 12 Jul 2015
Here we reported that ET-1 stimulated expression of VCAM-1 gene on HTSMCs, which was blocked by pretreatment with the inhibitors of ET receptors, Src, matrix metalloproteinases (MMPs), EGFR, PDGFR, PI3K, AKT, MEK1/2 and p300, suggesting the participation of these signaling components in ET-1-regulated HTSMC responses.
Activation of the MAPK/ERK Cell-Signaling Pathway in Uterine Smooth Muscle Cells of Women With Adenomyosis.
Batteux et al., Paris, France. In Reprod Sci, 11 Jul 2015
We studied whether the mitogen-activated protein kinases/extracellular signal-regulated kinases (MAPKs/ERKs) and phosphoinositide 3-kinase/mammalian target of rapamycin/AKT (PI3K/mTOR/AKT) cell-signaling pathways, implicated in the pathogenesis of endometriosis, might also be activated in uterine smooth muscle cells (uSMCs) of women with adenomyosis and measured the production of reactive oxygen species (ROS), proinflammatory mediators that modulate cell proliferation and have been shown to activate the MAPK/ERK pathway in endometriosis.
Mechanisms of growth-promoting and tumor-protecting effects of epithelial nicotinic acetylcholine receptors.
Grando et al., Irvine, United States. In Int Immunopharmacol, 09 Jul 2015
Activated cm-nAChRs were found to form complexes with receptors for EGF and VEGEF via the α7 and β2 nAChR subunits, respectively, whereas activated mt-nAChRs physically associated with the intramitochondrial protein kinases PI3K and Src via the α7 and β4 subunits.
Resveratrol improves hepatic insulin signaling and reduces the inflammatory response in streptozotocin-induced diabetes.
Koca et al., Karaman, Turkey. In Gene, 09 Jul 2015
In addition to hepatic glucose, lipid, insulin, ALT, AST, resistin and XOD contents, gene and protein expressions of insulin signaling pathway components such as insulin Rβ, IRS-1, IRS-2, eNOS, PI3K, Akt, and FOXO3a were analyzed by qRT-PCR and Western blot.
Kinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy.
Parsons et al., New York City, United States. In Cancer Cell, 08 Jul 2015
Here, resistance to a class I PI3K inhibitor in a model of metastatic breast cancer driven by PI3K and MYC was associated with feedback activation of tyrosine kinase receptors (RTKs), AKT, mTOR, and MYC.
A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis.
Largaespada et al., Minneapolis, United States. In Nat Genet, 30 Jun 2015
Analysis of CIS-associated genes identified numerous known and new osteosarcoma-associated genes enriched in the ErbB, PI3K-AKT-mTOR and MAPK signaling pathways.
Protective effects of epigallocatechin-3-gallate on intestinal ischemia reperfusion injury through enhanced activation of PI3K/Akt pathway in rats.
Chen et al., Wuhan, China. In J Huazhong Univ Sci Technolog Med Sci, 30 Jun 2015
Intestinal histology, pro-inflammatory cytokines and mediators were examined and the effect of EGCG on PI3K/Akt signalling was assessed.
Prevention of hepatocellular carcinoma by correction of metabolic abnormalities: Role of statins and metformin.
Romero-Gomez et al., Sevilla, Spain. In World J Hepatol, 18 Jun 2015
Otherwise, liver cancer is the result of a complex process which impairs several signaling cascades, such as RAS/RAF/mitogen-activated protein kinase kinase (MEK)/extracellular-signal-regulated kinase (ERK), phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) and Wnt/β-catenin signaling.
Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion.
Monje et al., Stanford, United States. In Cell, 07 Jun 2015
NLGN3 induced PI3K-mTOR pathway activity and feedforward expression of NLGN3 in glioma cells.
Transposon mutagenesis identifies genetic drivers of Braf(V600E) melanoma.
Jenkins et al., Houston, United States. In Nat Genet, 31 May 2015
CCGs are enriched in Wnt, PI3K, MAPK and netrin signaling pathway components and are more highly connected to one another than predicted by chance, indicating that SB targets cooperative genetic networks in melanoma.
Mammalian target of rapamycin and tuberous sclerosis complex.
Wataya-Kaneda, Ōsaka, Japan. In J Dermatol Sci, 25 May 2015
UNASSIGNED: Mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase that is a member of the phosphoinositide 3-kinase (PI3K)-related kinase (PIKK) family.
AXL mediates resistance to PI3Kα inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas.
Baselga et al., New York City, United States. In Cancer Cell, 13 May 2015
Phosphoinositide-3-kinase (PI3K)-α inhibitors have shown clinical activity in squamous cell carcinomas (SCCs) of head and neck (H&N) bearing PIK3CA mutations or amplification.
Families of microRNAs Expressed in Clusters Regulate Cell Signaling in Cervical Cancer.
López et al., Zacatecas, Mexico. In Int J Mol Sci, Dec 2014
Individual miRNA expression is reported without considering that miRNAs are grouped in clusters and may have similar functions, such as the case of clusters with anti-oncomiRs (23b~27b~24-1, miR-29a~29b-1, miR-29b-2~29c, miR-99a~125b-2, miR-99b~125a, miR-100~125b-1, miR-199a-2~214, and miR-302s) or oncomiRs activity (miR-1-1~133a-2, miR-1-2~133a-1, miR-133b~206, miR-17~92, miR-106a~363, miR183~96~182, miR-181a-1~181b-1, and miR-181a-2~181b-2), which regulated mitogen-activated protein kinases (MAPK), phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K), NOTCH, proteasome-culling rings, and apoptosis cell signaling.
MicroRNAs as Regulator of Signaling Networks in Metastatic Colon Cancer.
Yang et al., Yinchuan, China. In Biomed Res Int, Dec 2014
This paper reports the latest findings on miRNAs involved in different signaling networks leading to colon cancer metastasis, mainly focusing on miRNA profiling and their roles in PTEN/PI3K, EGFR, TGFβ, and p53 signaling pathways of metastatic colon cancer.
A critical evaluation of PI3K inhibition in Glioblastoma and Neuroblastoma therapy.
Debatin et al., Ulm, Germany. In Mol Cell Ther, 2013
Members of the PI3K/Akt/mTor signaling cascade are among the most frequently altered proteins in cancer, yet the therapeutic application of pharmacological inhibitors of this signaling network, either as monotherapy or in combination therapy (CT) has so far not been particularly successful.
Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy.
Weinberger et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2012
PIK3CD shows evidence of association with schizophrenia, and is a previously undescribed therapeutic target for the treatment of psychiatric disorders.
The p110δ subunit of PI3K regulates bone marrow-derived eosinophil trafficking and airway eosinophilia in allergen-challenged mice.
Sriramarao et al., Saint Paul, United States. In Am J Physiol Lung Cell Mol Physiol, 2012
PI3K p110delta mediates bone marrow-derived eosinophil trafficking and migration by regulating adhesion molecule expression and localization/distribution as well as promoting changes in cell morphology that favor recruitment during inflammation.
Attenuation of phosphoinositide 3-kinase δ signaling restrains autoimmune disease.
Hibbs et al., Melbourne, Australia. In J Autoimmun, 2012
agents targeting p110delta PI3K need not achieve full blockade of the enzyme to be of great benefit in the treatment of Systemic lupus erythematosus (SLE).
PI3 kinase δ is a key regulator of synoviocyte function in rheumatoid arthritis.
Firestein et al., San Diego, United States. In Am J Pathol, 2012
PI3 kinase delta is a key regulator of synoviocyte function in rheumatoid arthritis.
Genetic or pharmaceutical blockade of phosphoinositide 3-kinase p110δ prevents chronic rejection of heart allografts.
Marelli-Berg et al., London, United Kingdom. In Plos One, 2011
Data suggest that targeting phosphoinositol-3-kinase p110delta activity might be a viable strategy for the treatment of heart chronic rejection.
More papers using p110delta antibodies
Nuclear factor-κB signaling: a contributor in leukemogenesis and a target for pharmacological intervention in human acute myelogenous leukemia
Bruserud Øystein et al., In Bone Marrow Research, 2008
... The PI3K inhibitor 3-methyladenine (3-MA) and the specific IκB-kinase/NFκB inhibitor BMS-345541 were purchased from Sigma Aldrich (St ...
Non-Smad pathways in TGF-beta signaling
Spessotto Paola et al., In The Journal of Cell Biology, 2008
... Ser465/467 and linker region Ser245/250/255), anti-Smad2/3, anti–phospho-Akt (Thr308 and Ser 473), anti-Akt, anti-PTEN, and anti–PI3K p110-α antibodies were obtained from Cell Signaling Technology ...
Autophagy fights disease through cellular self-digestion
Wang Fen et al., In International Journal of Biological Sciences, 2007
... (Camarillo, CA), and PI3K (LY294002) was from Cell Signaling (Beverly, MA) ...
Optimization of Parameters for Semiempirical Methods V: Modification of NDDO Approximations and Application to 70 Elements
Kuboyama Tomoharu et al., In Scientific Reports, 2006
... The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 (Cayman Chemicals), MEK1 inhibitor PD98059 ...
Transactivation and signaling functions of Tat are not correlated: biological and immunological characterization of HIV-1 subtype-C Tat protein.
Kashanchi Fatah, In PLoS ONE, 2005
... (bFGF), epidermal growth factor (EGF), poly-D-lysine (PDL), Dulbecco's modified Eagle's medium (DMEM), morphine sulphate, specific PI3K inhibitor LY294002, etoposide and naloxone hydrochloride were all purchased from Sigma Aldrich (St ...
alpha-TEA inhibits survival and enhances death pathways in cisplatin sensitive and resistant human ovarian cancer cells
Kline K et al., In British Journal of Cancer, 2005
... Map kinase kinase (MEK) inhibitor (U01260) and PI3K inhibitor (wortmannin) were purchased from Cell Signaling Technology (Beverly, MA, USA) ...
Src kinase regulation by phosphorylation and dephosphorylation
Migliaccio Antimo, In PLoS ONE, 2004
... The Src inhibitor PP2, the EGFR inhibitor AG1478 and the PI3K inhibitor LY294002 were from Tocris Bioscience (Ellisville, MO) ...
FGF-23–Klotho signaling stimulates proliferation and prevents vitamin D–induced apoptosis
Lanske Beate et al., In The Journal of Cell Biology, 2004
... Azam, Harvard Medical School, Boston, MA) and PI3K (LY294002; Cell Signaling Technology) inhibitors were added ...
Targeting I kappa B kinase for the treatment of inflammatory and other disorders
Baharav Ehud et al., In Arthritis Research & Therapy, 2002
... AR and the signaling proteins PI3K, IKKα/β, were purchased from Santa Cruz Biotechnology Inc ...
Thioredoxin-mediated redox control of the transcription factor Sp1 and regulation of the thioredoxin gene promoter.
Cordes Nils, In PLoS ONE, 2002
... The general PI3K inhibitor, LY294002, was from Cell Signaling Biotechnology ...
The biological action of saponins in animal systems: a review.
Means Robert E., In PLoS ONE, 2001
... Antibodies against PI3K and phosphorylated PI3K were purchased from Cell Signaling Technology (Danvers, MA) ...
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
Pesce Maurizio, In PLoS ONE, 2000
... Louis, MO, USA); the PI3K inhibitor LY294002 and the PAFR human polyclonal antibody from Cayman Chemical (Ann Arbor, Michigan, ...
A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube
Farrar William L et al., In Molecular Cancer, 1999
... The following inhibitors were also used: Anti-human IL-6 antibody (R&D Systems, Minneapolis, MN), PI3K inhibitor LY294002 (Cell Signaling, Danvers, MA), Tec Kinase ...
The EGF receptor as central transducer of heterologous signalling systems.
Hong Wanjin, In PLoS ONE, 1998
... The Src inhibitors PP2, the PI3K inhibitor LY294002, 4-hydoxy tamoxifen (4-OHT) and ICI 182, 780 were from Tocris Bioscience (Ellisville, MO) ...
Vav3 Modulates B Cell Receptor Responses by Regulating Phosphoinositide 3-Kinase Activation
Kurosaki Tomohiro et al., In The Journal of Experimental Medicine, 1997
... purchased: anti-phosphotyrosine mAb (4G10), anti-Rac1 mAb, and rabbit anti-PI3K p85 Abs from Upstate Biotechnology, goat anti-PI3K p110α Abs (sc-1331) and goat anti-Akt1 Abs (sc-1618) from Santa Cruz Biotechnology, Inc., anti-c-Jun NH ...
Tumor necrosis factor-alpha in sera of obese patients: fall with weight loss
Goalstone Marc L et al., In Journal of Inflammation (London, England), 1997
... Kinase inhibitors PD98059 (for MEK1/2) and Wortmannin (for PI3K) were from Cell Signaling (Danvers, MA) ...
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
Cantrell Doreen et al., In The Journal of Cell Biology, 1995
... The PI3K inhibitor LY294002 was purchased from BIOMOL Research Laboratories, the histone ...
Positional cloning of the mouse obese gene and its human homologue
Abdel-Aal Abeer Abdel-Alim et al., In Journal of Veterinary Science, 1993
... Wortmannin (WT; a PI3K inhibitor) was from Biomol Research Laboratories (USA) ...
Eosinophil transendothelial migration induced by cytokines. I. Role of endothelial and eosinophil adhesion molecules in IL-1 beta-induced transendothelial migration
Heinemann Akos et al., In Cellular and Molecular Life Sciences, 1991
... The adenylyl cyclase inhibitor SQ22536, the PI3K inhibitor LY294002 and the PKC inhibitor chelerythrine were supplied from Biomol (Hamburg, Germany) ...
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
Peppelenbosch M P et al., In Cell Death & Disease, 1991
... The PI3K inhibitor LY294002 was from Alexis (Läufelingen, Switzerland) and TNFα was from Biovision Inc ...
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
Belkhiri Abbes, In PLoS ONE, 1989
... The PI3K siRNA kit was procured from Santa Cruz Biotechnology, Inc ...
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