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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Retinoblastoma-like 1

p107, Retinoblastoma-Like Protein, Retinoblastoma-Like Protein p107
The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD43, pRb, PCNA, CAN, E2F1
Papers on p107
Combinatorial PX-866 and Raloxifene Decrease Rb Phosphorylation, Cyclin E2 Transcription and Proliferation of MCF-7 Breast Cancer Cells.
New
Tollefsbol et al., Birmingham, United States. In J Cell Biochem, Jan 2016
Reduced phosphorylation of p107 and substantial reduction of Rb phosphorylation was observed in response.
Deletion of Rb1 induces both hyperproliferation and cell death in murine germinal center B cells.
New
Tomasson et al., Saint Louis, United States. In Exp Hematol, Jan 2016
We generated mice without Rb1 function in germinal center B cells by crossing Rb1(Flox/Flox) with C-γ-1-Cre (Cγ1) mice expressing the Cre recombinase in class-switched B cells in a p107(-/-) background to prevent p107 from compensating for Rb1 loss (Cγ1-Rb1(F/F)-p107(-/-)).
Repression by RB1 characterizes genes involved in the penultimate stage of erythroid development.
New
Ney et al., Memphis, United States. In Cell Cycle, Dec 2015
Retinoblastoma-1 (RB1), and the RB1-related proteins p107 and p130, are key regulators of the cell cycle.
Regulation of the retinoblastoma-E2F pathway by the ubiquitin-proteasome system.
Review
New
Henry et al., East Lansing, United States. In Biochim Biophys Acta, Oct 2015
The retinoblastoma tumor suppressor (RB) and its related family members p107 and p130 regulate cell proliferation through the transcriptional repression of genes involved in cellular G1 to S phase transition.
Hepatitis C virus core protein modulates pRb2/p130 expression in human hepatocellular carcinoma cell lines through promoter methylation.
Ruggieri et al., Roma, Italy. In J Exp Clin Cancer Res, 2014
We determined pRb, p107 and pRb2/p130 protein and mRNA amount of the respective genes RB1, RBL1 and RBL2, RBL2 promoter activity and methylation as well as DNA methyltransferase 1 (DNMT1) and 3b (DNMT3b) expression level.
Rb suppresses human cone-precursor-derived retinoblastoma tumours.
Impact
Cobrinik et al., New York City, United States. In Nature, 2014
Proliferation of Rb-depleted cones and retinoblastoma cells also depended on the Rb-related protein p107, SKP2, and a p27 downregulation associated with cone precursor maturation.
Coordination of proliferation and neuronal differentiation by the retinoblastoma protein family.
Review
Ajioka, Tokyo, Japan. In Dev Growth Differ, 2014
In this review, the coordination of cell cycle control and neuronal differentiation during development are discussed, focusing on regulation by the Rb family of tumor suppressors (including p107 and p130), and the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitors.
[Interactions of proliferation and differentiation signaling pathways in myogenesis].
Review
Grzelkowska-Kowalczyk et al., Warsaw, Poland. In Postepy Hig Med Dosw (online), 2013
At the molecular level, several key regulators of the cell cycle have been identified: cyclin-dependent kinases and their cyclins stimulate the cell cycle progress and its arrest is determined by the activity of cdk inhibitors (Cip/Kip and INK protein families) and pocket protein family: Rb, p107 and p130.
The DREAM complex: master coordinator of cell cycle-dependent gene expression.
Impact
DeCaprio et al., Bengaluru, India. In Nat Rev Cancer, 2013
The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex provides a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F, BMYB and forkhead box protein M1.
RB1 in cancer: different mechanisms of RB1 inactivation and alterations of pRb pathway in tumorigenesis.
Review
Vento et al., Palermo, Italy. In J Cell Physiol, 2013
The RB1gene is part of a larger gene family that includes RBL1 and RBL2, each of the three encoding structurally related proteins indicated as pRb, p107, and p130, respectively.
Skin Tumors Rb(eing) Uncovered.
Review
Santos et al., Madrid, Spain. In Front Oncol, 2012
The existence of a retinoblastoma family of proteins pRb, p107, and p130 and their potential unique and overlapping functions as master regulators of cell cycle progression and transcriptional modulation by similar processes, may provide potential clues to explain such conundrum.
miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma.
GeneRIF
MacPherson et al., Baltimore, United States. In Genes Dev, 2011
Data show that p21Cip1 inactivation increases proliferation in Rb/p107DKO retina
Retinoblastoma family of proteins and chromatin epigenetics: a repetitive story in a few LINEs.
Ramos et al., In Biomol Concepts, 2011
The retinoblastoma (RB) protein family in mammals is composed of three members: pRB (or RB1), p107, and p130.
Critical role of the Rb family in myoblast survival and fusion.
GeneRIF
Zacksenhaus et al., Toronto, Canada. In Plos One, 2010
Mutation of p107 or p130 reduces survival of Rb-deficient myoblasts during differentiation.
A 20.5-Mb germline deletion of 13q13.1-->q14.3 and somatic mutations of the RB1 gene in an 8-year-old girl with unilateral retinoblastoma, developmental delay and mental retardation.
GeneRIF
Wang et al., In Genet Couns, 2010
Concomitant germline large cytogenetic 13q deletion and somatic mutations in the RB1 gene in unilateral retinoblastoma.
B55alpha PP2A holoenzymes modulate the phosphorylation status of the retinoblastoma-related protein p107 and its activation.
GeneRIF
Graña et al., Philadelphia, United States. In J Biol Chem, 2010
identification of a PP2A trimeric holoenzyme containing B55alpha, which plays a major role in restricting the phosphorylation state of p107 and inducing its activation in human cells.
Oxidative status of muscle is determined by p107 regulation of PGC-1alpha.
GeneRIF
Rudnicki et al., Ottawa, Canada. In J Cell Biol, 2010
Data show that p107-deficient muscle expresses increased levels of peroxisome proliferator-activated receptor gamma co-activator-1alpha and contains increased numbers of the pro-oxidative type I and type IIa myofibers.
Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence.
Impact
Lowe et al., United States. In Cancer Cell, 2010
The RB protein family (RB, p107, and p130) has overlapping and compensatory functions in cell-cycle control.
What's so special about RB?
Impact
Sharpless et al., Chapel Hill, United States. In Cancer Cell, 2010
RB, p107, and p130 are highly related proteins, each capable of regulating cellular proliferation.
Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family.
Impact
GeneRIF
Sage et al., Stanford, United States. In Cell Stem Cell, 2008
along with Rb, and p130 maintains hematopoietic stem cells quiescence and the balance between lymphoid and myeloid cell lineages
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