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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Neural precursor cell expressed, developmentally down-regulated 9

p105, TFIIF, RAP74, RAP30, HEF1
This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: POLYMERASE, CAN, NF-kappaB, p65, Rel
Papers using p105 antibodies
Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats
Supplier
Roh Gu Seob et al., In Anatomy & Cell Biology, 2008
... Rabbit polyclonal antibodies against NF-κB p105/p50 and COX-2 were obtained from Abcam (Cambridge, MA, USA) and ...
Papers on p105
NFKB1: a Suppressor of Inflammation, Ageing and Cancer.
Review
New
Wilson et al., Newcastle upon Tyne, United Kingdom. In Febs J, Jan 2016
Here we discuss recent results that reveal that the NFKB1 (p105/p50) subunit is a critical regulator of NF-κB activity in vivo.
Mice null for NEDD9 (HEF1) display extensive hippocampal dendritic spine loss and cognitive impairment.
New
Clagett-Dame et al., Madison, United States. In Brain Res, Jan 2016
UNASSIGNED: NEDD9 (neural precursor cell expressed, developmentally down-regulated 9) is a member of the CAS (Crk-associated substrate) family of scaffolding proteins that regulate cell adhesion and migration.
Association and interaction of NFKB1 rs28362491 insertion/deletion ATTG polymorphism and PPP1R13L and CD3EAP related to lung cancer risk in a Chinese population.
New
Ma et al., Shenyang, China. In Tumour Biol, Dec 2015
UNASSIGNED: The nuclear factor of kappa light polypeptide gene enhancer in B cells 1 (NFKB1) gene encodes p105 and p50 kD which are both subunits of the transcription factor NF-kB, involved in a wide variety of diseases and pathological states associated with inflammation, immunity, and tumorigenesis.
Modulation of inflammatory response of wounds by antimicrobial photodynamic therapy.
New
Gupta et al., Indore, India. In Laser Ther, Nov 2015
RESULTS: In comparison with untreated control, while expression of TLR-4, NF-kB (p105 and p50), and proinflammatory interleukins (IL-1α, IL-1β,IL-2) were reduced in the infected wounds subjected to APDT, the levels of FGF-2 and ALP increased, on day 5 p.w. CONCLUSION: The measurements made on the inflammatory markers and cell proliferation markers suggest that APDT reduces inflammation caused by P.aeruginosa and promotes cell proliferation in wounds.
Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members.
Review
New
Golemis et al., Philadelphia, United States. In Gene, Nov 2015
The CAS (Crk-associated substrate) adaptor protein family consists of four members: CASS1/BCAR1/p130Cas, CASS2/NEDD9/HEF1/Cas-L, CASS3/EFS/Sin and CASS4/HEPL.
EP4 Receptor-Associated Protein in Macrophages Ameliorates Colitis and Colitis-Associated Tumorigenesis.
New
Chiba et al., Kyoto, Japan. In Plos Genet, Oct 2015
EPRAP deficiency increased the levels of the phosphorylated forms of p105, MEK, and ERK, resulting in activation of stromal macrophages in DSS-induced colitis.
Preclinical and clinical studies of the NEDD9 scaffold protein in cancer and other diseases.
Review
New
Golemis et al., Philadelphia, United States. In Gene, Sep 2015
NEDD9 (also known as CasL and HEF1) encodes a multi-domain scaffolding protein that assembles signaling complexes regulating multiple cellular processes relevant to cancer.
KPC1-mediated ubiquitination and proteasomal processing of NF-κB1 p105 to p50 restricts tumor growth.
New
Impact
Ciechanover et al., Haifa, Israel. In Cell, May 2015
One uncharacterized step is limited proteasomal processing of the NF-κB1 precursor p105 to the p50 active subunit.
Bioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancer.
Review
Golemis et al., Philadelphia, United States. In Physiol Genomics, 2014
Besides summarizing recent work in this area, we use four EMT-associated genes, TGF-β (TGFB1), NEDD9/HEF1, β-catenin (CTNNB1) and E-cadherin (CDH1), as exemplars to demonstrate the current capacities and limitations of probing bioinformatic resources to inform hypothesis-driven studies with therapeutic goals.
Cas proteins: dodgy scaffolding in breast cancer.
Review
Cabodi et al., Torino, Italy. In Breast Cancer Res, 2013
The members of the Cas protein family (p130Cas/BCAR1, Nedd9/HEF1, EFS and CASS4) are scaffold proteins required for the assembly of signal transduction complexes in response to several stimuli, such as growth factors, hormones and extracellular matrix components.
Critical Role of Glycogen Synthase Kinase-3β in Regulating the Avian Heterophil Response to Salmonella enterica Serovar Enteritidis.
Arsenault et al., College Station, United States. In Front Vet Sci, 2013
Using a phospho-specific antibody array confirmed the phosphorylation of GSK-3β (Ser9) as well as the phosphorylation of the downstream cytokine-activated intracellular signaling pathway involved in stimulating immune responses, IκB, the IκB subunit IKK-β, and the NF-κB subunits p105, p65, and c-Rel.
Structural visualization of key steps in human transcription initiation.
Impact
Nogales et al., Berkeley, United States. In Nature, 2013
Here we have used an in vitro reconstituted system to study the stepwise assembly of human TBP, TFIIA, TFIIB, Pol II, TFIIF, TFIIE and TFIIH onto promoter DNA using cryo-electron microscopy.
miRNAs, a potential target in the treatment of Non-Small-Cell Lung Carcinomas.
GeneRIF
Roussakis et al., Nantes, France. In Gene, 2012
HEF1 may have a role in carcinogenesis of lung cancer; miRNA be a therapeutic target
SCYL1 binding protein 1 promotes the ubiquitin-dependent degradation of Pirh2 and has tumor-suppressive function in the development of hepatocellular carcinoma.
GeneRIF
Guan et al., China. In Carcinogenesis, 2012
suggested that the interaction of SCYL1BP1/Pirh2 could accelerate Pirh2 degradation through an ubiquitin-dependent pathway. SCYL1BP1 may function as an important tumor suppressor gene in HCC development
Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1.
GeneRIF
Pendergast et al., Durham, United States. In Sci Signal, 2012
Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1.
Activator-mediator binding stabilizes RNA polymerase II orientation within the human mediator-RNA polymerase II-TFIIF assembly.
GeneRIF
Taatjes et al., Boulder, United States. In J Mol Biol, 2012
These results suggest that Mediator structural shifts induced by activator binding help stably orient pol II prior to transcription initiation within the human mediator-RNA polymerase II-TFIIF assembly.
Genome-wide structure and organization of eukaryotic pre-initiation complexes.
Impact
Pugh et al., United States. In Nature, 2012
PICs, including RNA polymerase II and protein complexes TFIIA, TFIIB, TFIID (or TBP), TFIIE, TFIIF, TFIIH and TFIIK were positioned within promoters and excluded from coding regions.
Transcriptional regulation by Pol II(G) involving mediator and competitive interactions of Gdown1 and TFIIF with Pol II.
GeneRIF
Roeder et al., New York City, United States. In Mol Cell, 2012
Gdown1 competes with TFIIF for binding to the RPB1 and RPB5 subunits of Pol II, thereby inhibiting an essential function of TFIIF in preinitiation complex assembly.
Integrin signalling adaptors: not only figurants in the cancer story.
Review
Impact
Defilippi et al., Torino, Italy. In Nat Rev Cancer, 2010
We specifically underline the contribution of p130 Crk-associated substrate (p130CAS; also known as BCAR1), neural precursor cell expressed, developmentally down-regulated 9 (NEDD9; also known as HEF1), CRK and the integrin-linked kinase (ILK)-pinch-parvin (IPP) complex to cancer, along with the more recently identified p140 Cas-associated protein (p140CAP; also known as SRCIN1).
Regulation and function of NF-kappaB transcription factors in the immune system.
Review
Impact
Karin et al., San Diego, United States. In Annu Rev Immunol, 2008
The mammalian Rel/NF-kappaB family of transcription factors, including RelA, c-Rel, RelB, NF-kappaB1 (p50 and its precursor p105), and NF-kappaB2 (p52 and its precursor p100), plays a central role in the immune system by regulating several processes ranging from the development and survival of lymphocytes and lymphoid organs to the control of immune responses and malignant transformation.
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