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Phosphoinositide-3-kinase, regulatory subunit 5

p101
Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: PI3K, CAN, p85, Akt, PI3K
Papers on p101
p84 forms a negative regulatory complex with p110γ to control PI3Kγ signalling during cell migration.
New
McColl et al., Adelaide, Australia. In Immunol Cell Biol, Sep 2015
Phosphoinositide 3-kinase γ (PI3Kγ) consists of the catalytic subunit p110γ that forms a mutually exclusive heterodimer with one of the two adaptor subunits, p101 or p84.
Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.
New
Nürnberg et al., Tübingen, Germany. In Biochem J, Aug 2015
PI3Kγ variants have one catalytic p110γ subunit that can form two different heterodimers by binding to one of a pair of non-catalytic subunits, p87 or p101.
Generation of cytotoxic T lymphocytes specific for native or modified peptides derived from the epidermal growth factor receptor pathway substrate 8 antigen.
New
He et al., Guangzhou, China. In Cancer Immunol Immunother, Feb 2015
p101-109-2L and p276-284-1Y9V were superior to other modified and native epitopes both in vitro and in vivo.
The regulatory subunits of PI3Kγ control distinct neutrophil responses.
New
Stephens et al., Cambridge, United Kingdom. In Sci Signal, Feb 2015
In neutrophils, PI3Kγ consists of a p110γ catalytic subunit, which is activated by the guanosine triphosphatase Ras, and either a p84 or p101 regulatory subunit.
miRNA-155 controls mast cell activation by regulating the PI3Kγ pathway and anaphylaxis in a mouse model.
Bulfone-Paus et al., Germany. In Allergy, 2014
Gene expression profiling showed that miR-155(-/-) BMMCs exhibited significantly increased expression of the adapter PI3Kγ subunits Pik3r5 (p101) and Pik3r6 (p84, p87(PIKAP) ).
Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs).
Williams et al., Cambridge, United Kingdom. In Proc Natl Acad Sci U S A, 2013
To gain insight into how the enzyme's activity is shaped by association with its p101 adaptor subunit, lipid membranes, and Gβγ heterodimers, we mapped these regulatory interactions using hydrogen-deuterium exchange mass spectrometry.
p87 and p101 subunits are distinct regulators determining class IB phosphoinositide 3-kinase (PI3K) specificity.
Nürnberg et al., Tübingen, Germany. In J Biol Chem, 2013
Class IB phosphoinositide 3-kinase γ (PI3Kγ) comprises a single catalytic p110γ subunit, which binds to two non-catalytic subunits, p87 or p101, and controls a plethora of fundamental cellular responses.
A missense mutation in PIK3R5 gene in a family with ataxia and oculomotor apraxia.
GeneRIF
Bohlega et al., Riyadh, Saudi Arabia. In Hum Mutat, 2012
Our characterization of the PIK3R5 protein and findings suggest that it may play a role in the development of the cerebellum and vermis.
No serological evidence for a role of HHV-6 infection in chronic fatigue syndrome.
Iadarola et al., Bethesda, United States. In Am J Transl Res, 2011
Here luciferase immunoprecipitation systems (LIPS) was used to develop HHV-6 serologic diagnostic tests using antigens encoded by the U11 gene from HHV-6A (p100) and HHV-6B (p101).
Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression.
Impact
Varner et al., San Diego, United States. In Cancer Cell, 2011
Whereas GPCRs activate p110γ in a Ras/p101-dependent manner, RTKs and TLR/IL1Rs directly activate p110γ in a Ras/p87-dependent manner.
The regulation of class IA PI 3-kinases by inter-subunit interactions.
Review
Backer, United States. In Curr Top Microbiol Immunol, 2009
The Class IB PI 3-kinase is also a dimer, composed of one regulatory subunit (p101 or p87) and one catalytic subunit (p110γ) (Wymann et al. 2003).
Class I PI3K in oncogenic cellular transformation.
Review
Vogt et al., Los Angeles, United States. In Oncogene, 2008
These isoforms combine with several regulatory subunits; for p110 alpha, beta and delta, the standard regulatory subunit is p85, for p110 gamma, it is p101.
HHV-6A in syncytial giant-cell hepatitis.
Impact
Guaraldi et al., Reggio nell'Emilia, Italy. In N Engl J Med, 2008
Expression of the HHV-6A-specific early protein, p41/38, but not of the HHV-6B-specific late protein, p101, was demonstrated only in liver syncytial giant cells in the absence of other infectious pathogens.
Overexpression of p101 activates PI3Kgamma signaling in T cells and contributes to cell survival.
GeneRIF
Levy et al., New Orleans, United States. In Oncogene, 2007
Overexpression of p101 activates PI3Kgamma signaling and is associated with T-cell lymphomas
Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils.
Impact
Stephens et al., United Kingdom. In Nat Cell Biol, 2006
Here, we have studied the roles of Gbetagammas, the adaptor p101, Ras and the Ras binding domain (RBD) in the control of the class I PI(3)K, PI(3)Kgamma, in mouse neutrophils.
Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase gamma.
GeneRIF
Schaefer et al., Berlin, Germany. In J Biol Chem, 2005
analysis of functional domains in the p101 regulatory subunit of phosphoinositide 3-kinase gamma
Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma.
GeneRIF
Nürnberg et al., Düsseldorf, Germany. In J Cell Biol, 2003
p101 has a role in membrane recruitment and activation of PI3K gamma
The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101.
Impact
Hawkins et al., Cambridge, United Kingdom. In Cell, 1997
Peptide sequence-based oligonucleotide probes were used to clone cDNAs for the p120 and p101 species.
A heterotrimeric GTPase-regulated isoform of PI3K and the regulation of its potential effectors.
Review
Cooke et al., Cambridge, United Kingdom. In Philos Trans R Soc Lond B Biol Sci, 1996
They are both heterodimers made up of a p120 and a p101 and a p117 and a p101 protein.
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