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Selectin P

P-selectin, CD62P
This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, CD45, GPIIb, CD63
Papers using P-selectin antibodies
Endothelial von Willebrand factor regulates angiogenesis.
Reitsma Pieter H., In PLoS ONE, 2010
... Rabbit polyclonal anti-P-selectin antibody was obtained from BD Biosciences, (San Jose, USA) ...
Effect of Rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
Gibbins J M et al., In Journal of Thrombosis and Haemostasis, 2006
... PE-Cy5 labeled anti-CD62P(P-selectin) was obtained from BD Biosciences (Oxford, UK) and MRS2179, ...
Foxp3+ regulatory T cells maintain immune homeostasis in the skin
Campbell Daniel J. et al., In The Journal of Experimental Medicine, 2004
... The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis.
Adherence to a Mediterranean diet and survival in a Greek population
Li Chi-Yuan et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2002
... antibody (mAb) conjugated with phycoerythrin (PE), which recognizes platelet glycoprotein IX complex independent of activation, anti-CD62P-PE antibody (Becton Dickinson), an mAb conjugated with ...
A Critical Temporal Window for Selectin-dependent CD4+ Lymphocyte Homing and Initiation of Late-Phase Inflammation in Contact Sensitivity
Kubes Paul et al., In The Journal of Experimental Medicine, 2000
... The antibodies used in this work were as follows: RB40.34, an antimurine P-selectin mAb (50 μg/mouse; BD Biosciences); R1-2, an antimurine α ...
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Papers on P-selectin
Inhibition of complement component C5 prevents clotting in an ex vivo model of xenogeneic activation of coagulation.
Tiede et al., Hannover, Germany. In Xenotransplantation, Feb 2016
Flow cytometry of human platelets after perfusion over WT-PAEC revealed an increase in platelet CD62P expression (29.5 ± 3%), compared to non-perfused PRP (7 ± 2%) or PRP running through empty flow chambers (12.7 ± 0.3%).
Coagulation Factor XI Promotes Distal Platelet Activation and Single Platelet Consumption in the Bloodstream Under Shear Flow.
McCarty et al., Nashville, United States. In Arterioscler Thromb Vasc Biol, Feb 2016
Downstream of the thrombus formed on immobilized collagen or collagen and 10 pmol/L tissue factor, platelet CD62P expression, microaggregate formation, and progressive platelet consumption were significantly reduced in the presence of FXI function-blocking antibodies or a thrombin inhibitor in a shear rate- and time-dependent manner.
Platelet activation at the onset of human endotoxemia is undetectable in vivo.
Assinger et al., Vienna, Austria. In Platelets, Feb 2016
Blood was drawn before, 10, 30 and 60 min after LPS challenge and platelet activation analyzed by flow cytometry (GPIIb/IIIa activation, surface CD62P and CD40L, intraplatelet reactive oxygen formation and platelet-leukocyte aggregates) and ELISA (sCD40L, sCD62P and CXCL4).
Bioavailability of Alfrutamide and Caffedymine and Their P-Selectin Suppression and Platelet-Leukocyte Aggregation Mechanisms in Mice.
Park, Beltsville, United States. In J Nutr, Feb 2016
However, the bioavailability of alfrutamide and caffedymine and their effects on cardiovascular diseases (CVDs), particularly via effects on P-selectin expression(PSE) and platelet-leukocyte aggregation (PLA), are unknown.
Assessment of platelet activation and immature platelet fraction as predictors of platelet engraftment after hematopoietic stem cell transplantation.
Tsay et al., In Cell Transplant, Feb 2016
To test whether platelet activation persists post-transplantation, two commonly used platelet activation marker antibodies, CD62P (P-selectin) and CD42b, were evaluated using whole blood flow cytometry, combining thiazole orange and anti-CD41a staining, to assess reticulated platelets.
Evaluation of the hemocompatibility and rapid hemostasis of (RADA)4 peptide-based hydrogels.
Unsworth et al., Edmonton, Canada. In Acta Biomater, Dec 2015
General hemocompatibility of (RADA)4 nanofibers was investigated systematically using clot formation kinetics, C3a generation, and platelet activation (morphology and CD62P) studies.
The diversity of platelet microparticles.
Brisson et al., Québec, Canada. In Curr Opin Hematol, Sep 2015
Circulating microparticles originating from megakaryocytes are distinguished from those derived from activated platelets by the presence of CD62P, LAMP-1, and immunoreceptor-based activation motif receptors.
Predictive value of markers of inflammation in the postthrombotic syndrome: a systematic review: inflammatory biomarkers and PTS.
Kahn et al., Montréal, Canada. In Thromb Res, Aug 2015
Nine reported on the association between C-reactive protein and PTS; Interleukin (IL)-6 was measured in six studies; IL-8 in four studies; Intracellular adhesion molecule (ICAM)-1 in three studies; IL-10 and vascular cell adhesion molecule-1 in two studies; and monocyte chemotactic protein-1, matrix metalloprotease-9, P-Selectin, tumor necrosis factor α and erythrocyte sedimentation rate were measured in one study.
Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species†.
Dong et al., Tianjin, China. In Plos One, 2014
RESULTS: PL dose-dependently blocked collagen-induced platelet aggregation, calcium influx, CD62p expression and thrombus formation on collagen with a maximal inhibition at 100 μM.
Arterial Hypertension Aggravates Innate Immune Responses after Experimental Stroke.
Wagner et al., Leipzig, Germany. In Front Cell Neurosci, 2014
Brain endothelial expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and P-selectin (CD62P) was neither increased by hypertension nor by stroke.
Changes in platelet function following cold storage of RBC suspensions.
Yang et al., Xi'an, China. In Int J Clin Exp Med, 2014
METHODS: Red blood cell suspensions (11 U and 50 U) were randomly selected at different storage times (3-28 days) and evidence of platelet activation (CD62P) and thromboelastography (TEG) reaction times were investigated.
Platelet parameters and expression of platelet membrane glycoprotein in childhood acute lymphoblastic leukemia.
Liu et al., China. In Genet Mol Res, 2014
Platelet parameters, immature platelet fraction (IPF%), immature platelet count (IPC), P-selectin (CD62p) (PAC-1) expression were detected in ALL, ALL-complete remission-induced (CR1), and normal groups with an automatic blood cell analyzer and flow cytometer.
Emerging anti-inflammatory drugs for atherosclerosis.
Rosenson et al., New York City, United States. In Expert Opin Emerg Drugs, 2013
These include antioxidants, phospholipase A(2) inhibitors, leukotriene pathway inhibitors, CCL2-CCR2 pathway inhibitors, non-specific anti-inflammatory drugs (i.e., methotrexate), IL-1 inhibitors and p-selectin inhibitors.
Relationship between Platelet PPARs, cAMP Levels, and P-Selectin Expression: Antiplatelet Activity of Natural Products.
Palomo et al., Talca, Chile. In Evid Based Complement Alternat Med, 2012
In this sense, the present paper describes mechanisms of antiplatelet action of natural products on platelet P-selectin expression through cAMP levels and its role as peroxisome proliferator-activated receptors agonists.
The role of endothelial cell adhesion molecules P-selectin, E-selectin and intercellular adhesion molecule-1 in leucocyte recruitment induced by exogenous methylglyoxal.
Liu et al., Saskatoon, Canada. In Immunology, 2012
the up-regulation of P-selectin, E-selectin and intercellular adhesion molecule-1 contributes to the increased leucocyte rolling flux, reduced leucocyte rolling velocity, and increased leucocyte adhesion, respectively.
P-selectin genotype is associated with the development of cancer cachexia.
European Palliative Care Research Collaborative et al., Edinburgh, United Kingdom. In Embo Mol Med, 2012
Identification of P-selectin as relevant in both animal models and in cachectic cancer patients supports this as a risk factor/potential mediator in cachexia.
Frequency distribution of single nucleotide polymorphisms in P-selectin gene in Chinese Tibetan and Han populations.
Jiang et al., Chengdu, China. In Gene, 2012
Data demonstrated that the frequency distributions of - 1969A/G and Ser290Asn polymorphisms in the Tibetan population were different from those in the Han population. The linkage disequilibrium of the P-selectin polymorphisms at positions - 2123C/G, - 1969A/G, - 1817T/C and Ser290Asn in Tibetans was not as tight as that in Europeans, and was weaker in the Han population.
Plant sterols and casein-derived tripeptides attenuate blood pressure increase in spontaneously hypertensive rats.
Vapaatalo et al., Helsinki, Finland. In Nutr Res, 2012
Aortic cyclooxygenase-2 and P-selectin were significantly down-regulated in plant sterols and plant sterols + tripeptides groups.
Endothelial cell markers in patients with pseudoexfoliation syndrome.
Kaźmierczak et al., Bydgoszcz, Poland. In Scientificworldjournal, 2011
Results indicate that there might be no correlation between pseudoexfoliation syndrome (PEX) and such endothelial cell markers as von Willebrand antigen (vWF Ag), E-selectin, and P-selectin concentrations
[Selectins as adhesion molecules and potential therapeutic target].
Marrakchi et al., Tunisia. In Arch Inst Pasteur Tunis, 2010
There are three types of selectin: the L-selectin (CD62L), which is constitutively expressed by most leukocyte populations, the P-selectin (CD62P) is found on activated platelets and endothelial cells, and the E-selectin (CD62E) expressed by activated endothelial cells.
More papers using P-selectin antibodies
Differential Requirement for LAT and SLP-76 in GPVI versus T Cell Receptor Signaling
Koretzky Gary A. et al., In The Journal of Experimental Medicine, 2000
... Anti–P-selectin was from BD PharMingen and anti-PLCγ2 was from Santa Cruz Biotechnology, Inc ...
The Junctional Adhesion Molecule 3 (JAM-3) on Human Platelets is a Counterreceptor for the Leukocyte Integrin Mac-1
Chavakis Triantafyllos et al., In The Journal of Experimental Medicine, 1999
... and fibrinogen (Dako); mAb MY4 specific for anti-CD14 (Beckman Coulter); blocking mAb GA6* against CD62P (P-selectin) and normal mouse IgG (Becton Dickinson).
Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation.
Gibbins Jonathan M. et al., In Blood, 1997
... Anti–P-selectin antibodies (AK-4) were purchased from BD Biosciences (Oxford, United Kingdom) ...
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