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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cadherin 3, type 1, P-cadherin

P-cadherin, CDHP, CDH3, cADP
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: E-cadherin, CAN, HAD, N-cadherin, V1a
Papers using P-cadherin antibodies
Cell adhesion protein expression in melanocytic matricoma
Supplier
Burchette James L et al., In Rare Tumors, 2006
... For P-cadherin, β-catenin, and HMB-45 manual staining, 1x Target Retrieval citrate buffer solution pH 6.1 (Dako) was used for 20 ...
Papers on P-cadherin
P-cadherin promotes collective cell migration via a Cdc42-mediated increase in mechanical forces.
New
Gauthier-Rouvière et al., Montpellier, France. In J Cell Biol, Feb 2016
Increased P-cadherin expression levels are correlated with tumor aggressiveness in carcinoma and aggressive sarcoma; however, how P-cadherin promotes tumor malignancy remains unknown.
Transcriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer.
New
Carracedo et al., Spain. In Oncotarget, Feb 2016
Importantly, transcriptomics characterization of uEVs led us to define the decreased abundance of Cadherin 3, type 1 (CDH3) transcript in uEV from PCa patients.
Serum Brain-Derived Neurotrophic Factor is Related to Platelet Reactivity but not to Genetic Polymorphisms within BDNF Encoding Gene in Patients with Type 2 Diabetes.
New
Postula et al., Warsaw, Poland. In Med Sci Monit, Dec 2015
RESULTS In multivariate linear regression analysis, CADP-CT >74 sec (p<0.001) and sP-selectin concentration (p=0.03) were predictive of high serum BDNF.
The role of P-cadherin in skin biology and skin pathology: lessons from the hair follicle.
Review
New
Paus et al., Tel Aviv-Yafo, Israel. In Cell Tissue Res, Jun 2015
Loss-of-function mutations in CDH3, which encodes P-cadherin, result in two allelic autosomal recessive disorders: hypotrichosis with juvenile macular dystrophy (HJMD) and ectodermal dysplasia, ectrodactyly, and macular dystrophy (EEM) syndromes.
Control of cell-cell forces and collective cell dynamics by the intercellular adhesome.
New
Impact
Trepat et al., Barcelona, Spain. In Nat Cell Biol, Apr 2015
Unexpectedly, we identified different mechanical roles for P-cadherin and E-cadherin; whereas P-cadherin predicts levels of intercellular force, E-cadherin predicts the rate at which intercellular force builds up.
Cell adhesion and urothelial bladder cancer: the role of cadherin switching and related phenomena.
Review
New
Bryan, Birmingham, United Kingdom. In Philos Trans R Soc Lond B Biol Sci, Mar 2015
However, the abnormal expression of N- and P-cadherin ('cadherin switching', CS) has been shown to promote a more invasive and m̀alignant phenotype of cancer, with P-cadherin possibly acting as a key mediator of invasion and metastasis in bladder cancer.
A-kinase anchor protein 4 (AKAP4) a promising therapeutic target of colorectal cancer.
Suri et al., New Delhi, India. In J Exp Clin Cancer Res, 2014
Our data also revealed elevated expression of epithelial marker E-cadherin and down regulation of EMT markers N-cadherin, P-cadherin, SLUG, α-SMA, SNAIL, TWIST and Vimentin.
P-cadherin and the journey to cancer metastasis.
Review
Paredes et al., Porto, Portugal. In Mol Cancer, 2014
P-cadherin is a classical cell-to-cell adhesion molecule with a homeostatic function in several normal tissues.
P-Cadherin Linking Breast Cancer Stem Cells and Invasion: A Promising Marker to Identify an "Intermediate/Metastable" EMT State.
Review
Paredes et al., Porto, Portugal. In Front Oncol, 2013
Herein, a brief review of evidences is presented, showing that P-cadherin expression, which has been already identified as a breast cancer stem cell marker and invasive promoter, is probably able to identify an intermediate EMT state associated with a metastable phenotype.
Epithelial E- and P-cadherins: role and clinical significance in cancer.
Review
Seruca et al., Porto, Portugal. In Biochim Biophys Acta, 2012
Genetic or epigenetic alterations in E- and P-cadherin-encoding genes (CDH1 and CDH3, respectively), or alterations in their proteins expression, often result in tissue disorder, cellular de-differentiation, increased invasiveness of tumour cells and ultimately in metastasis.
Immunohistochemical expression profile of β-catenin, E-cadherin, P-cadherin, laminin-5γ2 chain, and SMAD4 in colorectal serrated adenocarcinoma.
GeneRIF
Pérez-Guillermo et al., Cartagena, Spain. In Hum Pathol, 2012
Compared with conventional carcinomas, serrated adenocarcinomas showed no significant difference in P-cadherin staining.
P-cadherin is coexpressed with CD44 and CD49f and mediates stem cell properties in basal-like breast cancer.
GeneRIF
Paredes et al., Porto, Portugal. In Stem Cells, 2012
P-cadherin is coexpressed with CD44 and CD49f and mediates stem cell properties in basal-like breast cancer.
A novel nonsense CDH3 mutation in hypotrichosis with juvenile macular dystrophy.
GeneRIF
Bergman et al., Haifa, Israel. In Int J Dermatol, 2012
A novel nonsense CDH3 mutation in hypotrichosis with juvenile macular dystrophy
P-cadherin promotes liver metastasis and is associated with poor prognosis in colon cancer.
GeneRIF
Ran et al., Beijing, China. In Am J Pathol, 2011
High P-cadherin promotes liver metastasis and is associated with colon cancer.
Inhibition of BMP signaling in P-Cadherin positive hair progenitor cells leads to trichofolliculoma-like hair follicle neoplasias.
GeneRIF
Kessler et al., Chicago, United States. In J Biomed Sci, 2010
Inhibition of BMP signaling in P-Cadherin positive hair progenitor cells leads to trichofolliculoma-like hair follicle neoplasias
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
Impact
Strachan et al., In Nat Genet, 2009
We find genome-wide significant evidence of association at three new loci, each containing at least one biologically relevant candidate gene, on chromosomes 20q13 (HNF4A; P = 3.2 x 10(-17)), 16q22 (CDH1 and CDH3; P = 2.8 x 10(-8)) and 7q31 (LAMB1; P = 3.0 x 10(-8)).
Subtype and prognostic classification of rhabdomyosarcoma by immunohistochemistry.
Impact
Schäfer et al., Zürich, Switzerland. In J Clin Oncol, 2006
RESULTS: AP2beta and P-cadherin were selected as markers for pARMS, and epidermal growth factor receptor (EGFR) and fibrillin-2 as markers for ERMS.
Prognostic impact of alterations in P-cadherin expression and related cell adhesion markers in endometrial cancer.
Impact
Akslen et al., Bergen, Norway. In J Clin Oncol, 2004
In endometrial carcinoma, the prognostic impact of adhesion markers (E-cadherin, beta-catenin [beta-catenin], P-cadherin, and p120(ctn)) is partly unknown.
Increased Cytopathic Effect of Replicating Adenovirus Expressing Adenovirus Death Protein.
Yun et al., In Cancer Res Treat, 2003
To increase the oncolytic ability of YKL-1, an adenovirus death protein (ADP) gene was reintroduced under the control of a CMV or MLP promoter at the E3 region of the YKL-1, generating an YKL-cADP and YKL-mADP, respectively.
Hypotrichosis with juvenile macular dystrophy is caused by a mutation in CDH3, encoding P-cadherin.
Impact
Szargel et al., Haifa, Israel. In Nat Genet, 2001
This region contains CDH3, encoding P-cadherin, which is expressed in the retinal pigment epithelium and hair follicles.
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