GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 08 Dec 2016.
oxytocin receptor, OTR
The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. [provided by RefSeq, Jul 2008] (from
Caldwell et al., Kent, United States. In Horm Behav, 2012
It was shown that male aggression is heightened in oxytocinreceptor -/- mice, and that differential activation in the medial amygdala, and possibly the lateral septum, may be contributing to the heightened aggression.
The present review article seeks to further strengthen the argument in favour of the differential susceptibility theory by incorporating findings from behavioural and neuroanatomical studies in relation to genetic variation of the oxytocinreceptor gene. [Review]