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Oxytocin receptor

oxytocin receptor, OTR
The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Oxytocin, V1a, HAD, CAN, Neuropeptide
Papers on oxytocin receptor
Meta-analysis and association of two common polymorphisms of the human oxytocin receptor gene in autism spectrum disorder.
Chiocchetti et al., Trier, Germany. In Autism Res, Feb 2016
Variants of the OXT receptor gene (OXTR) have been tested for association with autism spectrum disorder (ASD) across manifold ethnicities, yielding both positive and negative findings.
Oxytocin receptor gene variation predicts subjective responses to MDMA.
de Wit et al., Houston, United States. In Soc Neurosci, Feb 2016
Thus, variation in the oxytocin receptor gene (OXTR) may influence responses to the drug.
Intracranial Transplantation of Hypoxia-Preconditioned iPS Cell-derived Neural Progenitor Cells Alleviates Neuropsychiatric Defects after Traumatic Brain Injury in Juvenile Rats.
Yu et al., In Cell Transplant, Feb 2016
Western blotting showed that HP-iPS-NPCs expressed significantly higher levels of the social behavior-related genes oxytocin and the oxytocin receptor.
Schuette et al., Chicago, United States. In Depress Anxiety, Feb 2016
Pubmed(®) and PsychINFO(®) were searched for biomedical and social sciences literature from 1960 to May 19, 2015 for empirical articles in English involving human subjects focused on the relationship between peripheral oxytocin concentration and depressive symptoms, excluding articles on the oxytocin receptor gene, or involving exogenous (i.e.
Carbetocin is a functional selective Gq agonist that does not promote oxytocin receptor recycling after inducing β-arrestin-independent internalisation.
Busnelli et al., Rozzano, Italy. In J Neuroendocrinol, Feb 2016
Using Bioluminescence Resonance Energy Transfer (BRET) biosensors, we characterised the effects of carbetocin on the three human oxytocin/vasopressin receptors expressed in the nervous system: the oxytocin receptor (OXTR) and the vasopressin V1a (V1aR) and V1b (V1bR) receptors.
Polymorphisms of two loci at the oxytocin receptor gene in populations of Africa, Asia and South Europe.
Butovskaya et al., Moscow, Russia. In Bmc Genet, Dec 2015
The goal of this study was to estimate the gender and population differences in polymorphisms of two oxytocin receptor gene SNPs, rs53576 and rs2254298, in four populations.
Salim et al., In Harefuah, Oct 2015
Tocolytic agents that have been used are: prostaglandin synthetase inhibitors, calcium channel antagonists, B-adrenergic agonists, magnesium and oxytocin receptor antagonists.
Oxytocin enables novelty seeking and creative performance through upregulated approach: evidence and avenues for future research.
Boot et al., Amsterdam, Netherlands. In Wiley Interdiscip Rev Cogn Sci, Sep 2015
Here we review this literature, focusing on the relationship between (1) single-nucleotide polymorphisms in the oxytocin receptor (OXTR) gene; endogenous oxytocin from blood plasma, and intranasal administration of oxytocin (vs placebo), and (2) creativity-related traits (e.g., novelty seeking, extraversion, and openness to experience), and behaviors (e.g., exploration, divergent thinking, original ideation, and problem solving).
Oxytocin and Estrogen Receptor β in the Brain: An Overview.
Handa et al., Houston, United States. In Front Endocrinol (lausanne), 2014
OT binds to the widely expressed OT receptor (OTR), and, in doing so, it regulates homeostatic processes, social recognition, and fear conditioning.
Pregnancy Recognition and Implantation of the Conceptus in the Mare.
Klein, Calgary, Canada. In Adv Anat Embryol Cell Biol, 2014
Oxytocin responsiveness is altered during early pregnancy, and reduced expression of the oxytocin receptor appears to be regulated at the posttranscriptional level rather than the transcriptional level.
Oxytocin modulates female sociosexual behavior through a specific class of prefrontal cortical interneurons.
Heintz et al., New York City, United States. In Cell, 2014
Here, we report the discovery of a population of somatostatin (Sst)-positive, regular spiking interneurons that express the oxytocin receptor (OxtrINs).
Oxytocin enhances hippocampal spike transmission by modulating fast-spiking interneurons.
Tsien et al., Stanford, United States. In Nature, 2013
Autism spectrum disorders (ASD) are associated with deficiencies in oxytocin levels and with genetic alterations of the oxytocin receptor (OXTR).
Differential susceptibility in spillover between interparental conflict and maternal parenting practices: evidence for OXTR and 5-HTT genes.
Suor et al., Rochester, United States. In J Fam Psychol, 2012
Mothers with the GG genotype of OXTR rs53576 show greater differential maternal sensitivity across varying levels of interparental conflict.
Heightened aggressive behavior in mice with lifelong versus postweaning knockout of the oxytocin receptor.
Caldwell et al., Kent, United States. In Horm Behav, 2012
It was shown that male aggression is heightened in oxytocin receptor -/- mice, and that differential activation in the medial amygdala, and possibly the lateral septum, may be contributing to the heightened aggression.
Influence of COX-2 and OXTR polymorphisms on treatment outcome in treatment resistant depression.
Serretti et al., Brussels, Belgium. In Neurosci Lett, 2012
We did not observe any association between the genotypes or alleles of the selected SNPs within COX-2 and OXTR genes and treatment resistance, response and remission in the whole sample
The neurogenetics of nice: receptor genes for oxytocin and vasopressin interact with threat to predict prosocial behavior.
Buffone et al., Buffalo, United States. In Psychol Sci, 2012
greater perceived threat predicted engagement in fewer charitable activities for individuals with A/A and A/G genotypes of OXTR rs53576, but not for G/G individuals
Does the oxytocin receptor (OXTR) polymorphism (rs2254298) confer 'vulnerability' for psychopathology or 'differential susceptibility'? Insights from evolution.
Brüne, Bochum, Germany. In Bmc Med, 2011
The present review article seeks to further strengthen the argument in favour of the differential susceptibility theory by incorporating findings from behavioural and neuroanatomical studies in relation to genetic variation of the oxytocin receptor gene. [Review]
Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway.
Yada et al., Tochigi, Japan. In Cell Metab, 2009
Nesfatin-1-induced anorexia is abolished by an oxytocin receptor antagonist.
Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal brain during delivery.
Khazipov et al., Marseille, France. In Science, 2007
In vivo administration of an oxytocin receptor antagonist before delivery prevented the switch of GABA actions in fetal neurons and aggravated the severity of anoxic episodes.
Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations.
Meaney, Montréal, Canada. In Annu Rev Neurosci, 2000
Maternal care also influences the maternal behavior of female offspring, an effect that appears to be related to oxytocin receptor gene expression, and which forms the basis for the intergenerational transmission of individual differences in stress reactivity.
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