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Thioredoxin reductase 1

oxidoreductase, thioredoxin reductase
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Thioredoxin, CAN, V1a, ACID, Nrf2
Papers on oxidoreductase
Quercetin lowers plasma uric acid in pre-hyperuricaemic males: a randomised, double-blinded, placebo-controlled, cross-over trial.
New
Williamson et al., Leeds, United Kingdom. In Br J Nutr, Feb 2016
Quercetin, a flavonoid found in high levels in onions, tea and apples, inhibits xanthine oxidoreductase in vitro, the final step in intracellular uric acid production, indicating that quercetin might be able to lower blood uric acid in humans.
Involvement of Nuclear Related Factor 2 Signaling Pathway in the Brain of Obese Rats and Obesity-Resistant Rats Induced by High-Fat Diet.
New
Xiao et al., Beijing, China. In J Med Food, Feb 2016
In addition, the protein expression of Nrf2 and its downstream factors such as heme oxygenase 1, manganese superoxide dismutase, and NAD(P)H quinone oxidoreductase 1 (NQO1) in the brain tissue were measured by Western blotting.
Reference genes selection and relative expression analysis from Shiraia sp. SUPER-H168 productive of hypocrellin.
New
Cai et al., Wuxi, China. In Gene, Feb 2016
We further analyzed relative expression levels of essential proteins correlative with hypocrellin biosynthesis, including polyketide synthase (PKS), O-methyltransferase (Omef), FAD/FMN-dependent oxidoreductase (FAD), and monooxygenase (Mono).
TaOPR2 encodes a 12-oxo-phytodienoic acid reductase involved in the biosynthesis of jasmonic acid in wheat (Triticum aestivum L.).
New
Zhao et al., Beijing, China. In Biochem Biophys Res Commun, Feb 2016
TaOPR2 has NADPH-dependent oxidoreductase activity.
An unexplored role for Peroxiredoxin in exercise-induced redox signalling?
Review
New
Coles et al., Worcester, United Kingdom. In Redox Biol, Jan 2016
UNASSIGNED: Peroxiredoxin (PRDX) is a ubiquitous oxidoreductase protein with a conserved ionised thiol that permits catalysis of hydrogen peroxide (H2O2) up to a million times faster than any thiol-containing signalling protein.
Xanthine oxidoreductase in cancer: more than a differentiation marker.
Review
New
Bolognesi et al., Bologna, Italy. In Cancer Med, Jan 2016
UNASSIGNED: Human xanthine oxidoreductase (XOR) catalyzes the last two steps of purine catabolism and is present in two interconvertible forms, which may utilize O2 or NAD(+) as electron acceptors.
Chemical biology of anticancer gold(iii) and gold(i) complexes.
Review
New
Impact
Che et al., Hong Kong, Hong Kong. In Chem Soc Rev, Jan 2016
Similar to most Au(i) complexes, Au(iii) complexes can inhibit the activities of thiol-containing enzymes, including thioredoxin reductase, via ligand exchange reactions to form Au-S(Se) bonds.
Repairing oxidized proteins in the bacterial envelope using respiratory chain electrons.
New
Impact
Barras et al., Brussels, Belgium. In Nature, Jan 2016
A remarkable feature of MsrPQ is its capacity to reduce both rectus (R-) and sinister (S-) diastereoisomers of methionine sulfoxide, making this oxidoreductase complex functionally different from previously identified Msrs.
Assembly of the Escherichia coli NADH:ubiquinone oxidoreductase (respiratory complex I).
Review
New
Burschel et al., Freiburg, Germany. In Biochim Biophys Acta, Jan 2016
UNASSIGNED: Energy-converting NADH:ubiquinone oxidoreductase, respiratory complex I, couples the electron transfer from NADH to ubiquinone with the translocation of four protons across the membrane.
Disulfide bond-forming pathways in Gram-positive bacteria.
Review
New
Ton-That et al., Houston, United States. In J Bacteriol, Jan 2016
In both organisms, disulfide bonds are catalyzed by the membrane-bound oxidoreductase MdbA.
Extracellular electron transfer from cathode to microbes: application for biofuel production.
Review
New
Sang et al., Seoul, South Korea. In Biotechnol Biofuels, Dec 2015
It was proposed that gram-positive bacteria, in the absence of cytochrome C, would accept electrons using a cascade of membrane-bound complexes such as membrane-bound Fe-S proteins, oxidoreductase, and periplasmic enzymes.
Deoxynyboquinones as NQO1-Activated Cancer Therapeutics.
New
Impact
Hergenrother et al., Urbana, United States. In Acc Chem Res, Nov 2015
A potential cancer-specific target is the enzyme NAD(P)H quinone oxidoreductase 1 (NQO1).
The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca(2+) Uptake.
New
Impact
Riemer et al., Kaiserslautern, Germany. In Cell Metab, Nov 2015
The essential oxidoreductase Mia40/CHCHD4 mediates disulfide bond formation and protein folding in the mitochondrial intermembrane space.
Omeprazole does not Potentiate Acute Oxygen Toxicity in Fetal Human Pulmonary Microvascular Endothelial Cells Exposed to Hyperoxia.
New
Shivanna et al., Houston, United States. In Pharm Anal Acta, Oct 2015
Furthermore, OM at a concentration of 100 μM (OM 100) increased NADP(H) quinone oxidoreductase 1 (NQO1) expression.
Plant science. Morphinan biosynthesis in opium poppy requires a P450-oxidoreductase fusion protein.
New
Impact
Graham et al., York, United Kingdom. In Science, Aug 2015
Characterization of high-reticuline poppy mutants revealed a genetic locus, designated STORR [(S)- to (R)-reticuline] that encodes both cytochrome P450 and oxidoreductase modules, the latter belonging to the aldo-keto reductase family.
Estrogen receptor β and 17β-hydroxysteroid dehydrogenase type 6, a growth regulatory pathway that is lost in prostate cancer.
GeneRIF
Gustafsson et al., Houston, United States. In Proc Natl Acad Sci U S A, 2012
17beta-hydroxysteroid dehydrogenase type 6 (17betaHSD6) converts the androgen DHT to the estrogen 3beta-Adiol, and this leads to activation of the ERbeta reporter.
An integrative genomics approach identifies activation of thioredoxin/thioredoxin reductase-1-mediated oxidative stress defense pathway and inhibition of angiogenesis in obese nondiabetic human subjects.
GeneRIF
Elbein et al., Winston-Salem, United States. In J Clin Endocrinol Metab, 2011
Our study suggests a novel interaction of up-regulated TXN-TXNRD1 system-mediated oxidative stress defense mechanisms and down-regulated angiogenesis pathways as an adaptive response in obese nondiabetic subjects.
Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors.
GeneRIF
Filipovska et al., Perth, Australia. In Free Radic Biol Med, 2011
study reveals significant differences between TrxR1 and TrxR2 in substrate specificity and metal compound inhibition in vitro and in cells
Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma.
GeneRIF
Uzawa et al., Chiba, Japan. In Oncol Rep, 2011
Overexpression of TrxR1 could contribute to cancer progression and might be a potential molecular marker for therapy.
Thioredoxin reductase 1 knockdown enhances selenazolidine cytotoxicity in human lung cancer cells via mitochondrial dysfunction.
GeneRIF
Moos et al., Salt Lake City, United States. In Biochem Pharmacol, 2011
These results indicate the ability of TR1 to modulate the cytotoxic effects of selenium compounds in human lung cancer cells through mitochondrial dysfunction.
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