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OVO homolog-like 1

Ovol1, movo1, ovo1, mOvo1a
This gene encodes a putative zinc finger containing transcription factor that is highly similar to homologous protein in Drosophila and mouse. Based on known functions in these species, this protein is likely involved in hair formation and spermatogenesis in human as well. [provided by RefSeq, Aug 2011] (from NCBI)
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Top mentioned proteins: c-Myc, KIF3A, HAIR, ZEB1, TGF-beta
Papers on Ovol1
OVO-like 1 regulates progenitor cell fate in human trophoblast development.
New
Soares et al., Kansas City, United States. In Proc Natl Acad Sci U S A, Dec 2015
In this study, we show that the transcription factor OVO-like 1 (OVOL1), a homolog of Drosophila ovo, regulates the transition from progenitor to differentiated trophoblast cells.
Correlation of KIF3A and OVOL1, but not ACTL9, with atopic dermatitis in Chinese pediatric patients.
New
Xu et al., Shanghai, China. In Gene, Nov 2015
Three single nucleotide polymorphisms have previously been associated with AD in Europeans, rs2897442 (KIF3A), rs479844 (OVOL1) and rs2164983 (ACTL9).
Molecular profiling of tumour budding implicates TGFβ-mediated epithelial-mesenchymal transition as a therapeutic target in oral squamous cell carcinoma.
New
von Buchwald et al., Copenhagen, Denmark. In J Pathol, Aug 2015
Transcription factors ZEB1 and PRRX1 were up-regulated concomitantly with the decreased expression of mesenchymal-epithelial (MET) transcription factors (eg OVOL1) in addition to Krüppel-like factors and Grainyhead-like factors.
Knockdown of polycomb-group RING finger 6 modulates mouse male germ cell differentiation in vitro.
Wu et al., Shanghai, China. In Cell Physiol Biochem, 2014
Luciferase reporter assays were performed to examine the promoter activity of PCGF6 in cells overexpressing OVOL1 and PLZF.
Meta-analysis identifies seven susceptibility loci involved in the atopic march.
Lee et al., Berlin, Germany. In Nat Commun, 2014
AP5B1/OVOL1 (11q13.1),
Preferential expression of OVOL1 in inner root sheath of hair, sebaceous gland, eccrine duct and their neoplasms in human skin.
Furue et al., In Fukuoka Igaku Zasshi, 2014
OVOL1 is an important transcription factor for epidermal keratinization, which suppresses proliferation and switches on the differentiation of keratinocytes.
Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells.
Dai et al., Irvine, United States. In Dev Cell, 2014
Here, we report that simultaneous ablation of transcriptional repressor-encoding Ovol1 and Ovol2 results in expansion and blocked terminal differentiation of embryonic epidermal progenitor cells.
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
Barker et al., London, United Kingdom. In Nat Commun, 2013
All three loci contain genes linked to the TGFβ cell signalling pathway, namely OVOL1, FST and TGFB2.
Gene expression correlations in human cancer cell lines define molecular interaction networks for epithelial phenotype.
Pommier et al., Bethesda, United States. In Plos One, 2013
The most highly correlated genes were implicated in the following epithelial functions: interactions at tight junctions (CLDN7, CLDN4, CLDN3, MARVELD3, MARVELD2, TJP3, CGN, CRB3, LLGL2, EPCAM, LNX1); interactions at adherens junctions (CDH1, ADAP1, CAMSAP3); interactions at desmosomes (PPL, PKP3, JUP); transcription regulation of cell-cell junction complexes (GRHL1 and 2); epithelial RNA splicing regulators (ESRP1 and 2); epithelial vesicle traffic (RAB25, EPN3, GRHL2, EHF, ADAP1, MYO5B); epithelial Ca(+2) signaling (ATP2C2, S100A14, BSPRY); terminal differentiation of epithelial cells (OVOL1 and 2, ST14, PRSS8, SPINT1 and 2); maintenance of apico-basal polarity (RAB25, LLGL2, EPN3).
Association of KIF3A, but not OVOL1 and ACTL9, with atopic eczema in Italian patients.
Giardina et al., Roma, Italy. In Br J Dermatol, 2013
BACKGROUND: Atopic eczema (AE) (OMIM %603165) is the most common chronic inflammatory skin disease characterized by xerosis, pruritus, and erythematous lesions with increased transepidermal water loss.
Long non-coding RNA expression profiling of mouse testis during postnatal development.
Wu et al., Shanghai, China. In Plos One, 2012
Many lncRNAs overlapped or were adjacent to key transcription factors and other genes involved in spermatogenesis, such as Ovol1, Ovol2, Lhx1, Sox3, Sox9, Plzf, c-Kit, Wt1, Sycp2, Prm1 and Prm2.
Transcription factors OVOL1 and OVOL2 induce the mesenchymal to epithelial transition in human cancer.
Pienta et al., Ann Arbor, United States. In Plos One, 2012
We demonstrate a novel function of two TFs, OVOL1 and OVOL2, as critical inducers of MET in human cancers.
Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
Impact
Tamari et al., Yokohama, Japan. In Nat Genet, 2012
We also replicated the associations of the FLG, C11orf30, TMEM232-SLC25A46, TNFRSF6B-ZGPAT, OVOL1, ACTL9 and KIF3A-IL13 loci that were previously reported in GWAS of European and Chinese individuals and a meta-analysis of GWAS for atopic dermatitis.
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.
Impact
EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium et al., Bristol, United Kingdom. In Nat Genet, 2012
Three SNPs reached genome-wide significance in the discovery and replication cohorts combined, including rs479844 upstream of OVOL1 (odds ratio (OR) = 0.88, P = 1.1 × 10(-13)) and rs2164983 near ACTL9 (OR = 1.16,
Molecular phylogeny of OVOL genes illustrates a conserved C2H2 zinc finger domain coupled by hypervariable unstructured regions.
Grapputo et al., Padova, Italy. In Plos One, 2011
Using comparative genomic analysis, we traced three different OVOL genes (OVOL1-3) in vertebrates.
Strain-dependent perinatal lethality of Ovol1-deficient mice and identification of Ovol2 as a downstream target of Ovol1 in skin epidermis.
GeneRIF
Dai et al., Irvine, United States. In Biochim Biophys Acta, 2007
Ovol1 mutant mice suffered perinatal lethality accompanied by kidney epithelial cysts of embryonic onset and delayed skin barrier acquisition; Ovol2 is a downstream target of Ovol1.
Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression.
GeneRIF
Dai et al., Irvine, United States. In Development, 2005
regulates pachytene progression of male germ cells, Id2 is target
The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation.
GeneRIF
Dai et al., Irvine, United States. In Proc Natl Acad Sci U S A, 2002
The LEF1/beta -catenin complex activates movo1
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