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DPH1 homolog

OVCA1, Dph1, DPH2L, DPH2L1
Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH1 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: DPH2, Elongation Factor 2, p53, CAN, HAD
Papers on OVCA1
Matching two independent cohorts validates DPH1 as a gene responsible for autosomal recessive intellectual disability with short stature, craniofacial, and ectodermal anomalies.
Innes et al., Calgary, Canada. In Hum Mutat, Oct 2015
One such gene was DPH1, in which a homozygous missense mutation was associated with a 3C syndrome-like phenotype in four patients from a single extended family.
Redox status of high-mobility group box 1 performs a dual role in angiogenesis of colorectal carcinoma.
Li et al., Shanghai, China. In J Cell Mol Med, Sep 2015
To measure the expression of VEGF-A and angiogenic properties of the endothelial cells (ECs), at-HMGB1 or ds-HMGB1 was added to cell medium, further with their special inhibitors (DPH1.1 mAb and 2G7 mAb) and antibodies of corresponding receptors (RAGE Ab and TLR4 Ab).
Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor.
Brinkmann et al., Penzberg, Germany. In Proc Natl Acad Sci U S A, Sep 2015
This modification is synthesized by seven dipthamide biosynthesis proteins (DPH1-DPH7) and is conserved among eukaryotes and archaea.
Accelerating novel candidate gene discovery in neurogenetic disorders via whole-exome sequencing of prescreened multiplex consanguineous families.
Alkuraya et al., Riyadh, Saudi Arabia. In Cell Rep, Feb 2015
This prescreening step led to the identification of 69 recessive genes not previously associated with disease, of which 33 are here described (SPDL1, TUBA3E, INO80, NID1, TSEN15, DMBX1, CLHC1, C12orf4, WDR93, ST7, MATN4, SEC24D, PCDHB4, PTPN23, TAF6, TBCK, FAM177A1, KIAA1109, MTSS1L, XIRP1, KCTD3, CHAF1B, ARV1, ISCA2, PTRH2, GEMIN4, MYOCD, PDPR, DPH1, NUP107, TMEM92, EPB41L4A, and FAM120AOS).
The diphthamide modification pathway from Saccharomyces cerevisiae--revisited.
Stark et al., Leicester, United Kingdom. In Mol Microbiol, 2014
However, recent progress in dissecting the diphthamide gene network (DPH1-DPH7) from the budding yeast Saccharomyces cerevisiae has significantly advanced our understanding of the mechanisms required to initiate and complete diphthamide synthesis on EF2.
Role of OVCA1/DPH1 in craniofacial abnormalities of Miller-Dieker syndrome.
Chen et al., Taipei, Taiwan. In Hum Mol Genet, 2014
OVCA1/DPH1 (OVCA1) encodes a component of the diphthamide biosynthesis pathway and is located on chromosome 17p13.3.
Methylation of the DPH1 promoter causes immunotoxin resistance in acute lymphoblastic leukemia cell line KOPN-8.
Pastan et al., Bethesda, United States. In Leuk Res, 2013
To understand how to increase response rate, we isolated HA22-resistant KOPN-8 cells and found that HA22 cannot inactivate elongation factor-2 (EF2) due to low levels of DPH1 RNA and protein.
Insights into diphthamide, key diphtheria toxin effector.
Schaffrath et al., Kassel, Germany. In Toxins (basel), 2013
In budding yeast, diphthamide formation involves seven genes, DPH1-DPH7.
The amidation step of diphthamide biosynthesis in yeast requires DPH6, a gene identified through mining the DPH1-DPH5 interaction network.
Schaffrath et al., Leicester, United Kingdom. In Plos Genet, 2012
In Saccharomyces cerevisiae, the initial steps of diphthamide biosynthesis are well characterized and require the DPH1-DPH5 genes.
Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development.
Leppla et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2012
Therefore, in contrast to mouse embryonic fibroblasts (MEFs) from OVCA1(-/-) mice, eEF2(G717R/G717R) MEFs retain full activity in polypeptide elongation and have normal growth rates.
Pharmacokinetics and organ distribution of diarylheptanoid phytoestrogens from Curcuma comosa in rats.
Sripanidkulchai et al., Khon Kaen, Thailand. In J Nat Med, 2012
HPLC was used to measure the concentration of three major compounds, (6E)-1,7-diphenylhept-6-en-3-one (DPH1), (4E,6E)-1,7-diphenylhepta-4,6-dien-3-ol (DPH2), and (6E)-1,7-diphenylhept-6-en-3-ol (DPH3), which were found to be present in the blood and tissues and were subsequently used as markers.
OVCA1 inhibits the proliferation of epithelial ovarian cancer cells by decreasing cyclin D1 and increasing p16.
Zhao et al., Dalian, China. In Mol Cell Biochem, 2011
OVCA1 could inhibit the proliferation of ovarian cancer cells by p16/cyclin D1 pathway, but not by NF-kappaB
[Chromosome arm 17p13.3: could HIC1 be the one ?].
Leprince et al., Villeneuve-d'Ascq, France. In Med Sci (paris), 2006
HIC1 (hypermethylated in cancer 1) and OVCA1 (ovarian cancer gene 1).
OVCA1: tumor suppressor gene.
Behringer et al., Taipei, Taiwan. In Curr Opin Genet Dev, 2005
OVCA1, also known as DPH2L1, is a tumor suppressor gene associated with ovarian carcinoma and other tumors.
Ovca1 regulates cell proliferation, embryonic development, and tumorigenesis.
Behringer et al., Houston, United States. In Genes Dev, 2004
Ovca1 is a tumor suppressor that can modify p53-induced tumorigenesis and suggest that it acts as a positive regulator for cell cycle progression.
Genetic factors in ovarian carcinoma.
Karlan et al., Los Angeles, United States. In Curr Oncol Rep, 2001
Novel genes recently implicated in ovarian tumorigenesis are discussed, including NOEY2, OVCA1, and PIK3CA.
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