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Protein tyrosine phosphatase type IVA, member 2

OV-1, PRL-2
The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010] (from NCBI)
Top mentioned proteins: fibrillin-1, ACID, Prolactin, CAN, PRL-1
Papers on OV-1
Low programmed cell death 5 expression is a prognostic factor in ovarian cancer.
Chang et al., Beijing, China. In Chin Med J (engl), May 2015
METHODS: Expression levels of PDCD5 mRNA and protein were examined in six ovarian cancer cell lines (SKOV3, CAOV3, ES2, OV1, 3AO, and HOC1A) and one normal ovarian epithelial cell line (T29) using reverse transcription polymerase chain reaction, Western blotting, and flow cytometry.
The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis.
Tremblay et al., Montréal, Canada. In Oncogene, Mar 2015
Among the subfamily of PRL phosphatases, overexpression of PRL-2 in breast cancer cells has been shown to promote tumor growth by a mechanism that remains to be uncovered.
Five-year followup of knee joint cartilage thickness changes after acute rupture of the anterior cruciate ligament.
Frobell et al., Salzburg, Austria. In Arthritis Rheumatol, 2015
However, the maximal annualized subregional cartilage loss (OV1) and gain (OV16) were both significantly greater (P < 0.001 and P < 0.05, respectively) during the earlier interval than during the later interval (-115 versus -54 μm [OV1] and 116 versus 69 μm [OV16]).
Biochemical evaluation of virtual screening methods reveals a cell-active inhibitor of the cancer-promoting phosphatases of regenerating liver.
Köhn et al., Heidelberg, Germany. In Eur J Med Chem, 2015
The compound is active in cells, as shown by its ability to specifically revert PRL-3 induced cell migration, and exhibits similar effects on PRL-1 and PRL-2.
Procyanidins Negatively Affect the Activity of the Phosphatases of Regenerating Liver.
Köhn et al., Heidelberg, Germany. In Plos One, 2014
Remarkably, the tested procyanidins showed selectivity in vitro when compared to other PPs, and over 10-fold selectivity toward PRL-1 over PRL-2 and PRL-3.
Cell cycle inhibitory activity of Piper longum against A549 cell line and its protective effect against metal-induced toxicity in rats.
Pandey et al., In Indian J Biochem Biophys, 2014
Hexane extracts exhibited 90-92% cytotoxicity against most of the test cell lines (A549, THP-1, IGR-OVI-1 and MCF-7), while benzene extract displayed 84-87% cytotoxicity against MCF-7, IGR-OV-1 and THP-1 cell lines.
A purge and trap integrated microGC platform for chemical identification in aqueous samples.
Agah et al., Blacksburg, United States. In Analyst, 2014
The trapped compounds are desorbed from the μTPC by resistive heating using the on-chip heater and temperature sensor, are separated by a 2 m long, 80 μm wide, and 250 μm deep polydimethylsiloxane (OV-1) coated μGC separation column, and are identified using a micro-thermal conductivity detector (μTCD) monolithically integrated with the column.
Double-locus sequence typing using porA and peb1A for epidemiological studies of Campylobacter jejuni.
Ivanova et al., Australia. In Foodborne Pathog Dis, 2014
The DLST scheme was validated using 50 clinical and environmental C. jejuni strains isolated from human (C5, H, H15-H19), chicken (CH1-CH15), water (W2-W17), and ovine samples (OV1-OV6).
Pharmacognostic standardisation and antiproliferative activity of Aegle marmelos (L.) Correa leaves in various human cancer cell lines.
Ishar et al., Amritsar, India. In Indian J Pharm Sci, 2013
Hexane, petroleum ether, chloroform and ethanol extracts of the shade dried leaves were prepared by soxhelation and antiproliferative activity was assessed using human cancer cell lines of lung (A-549), colon (CoLo-05), ovary (IGR-OV-1), prostrate (PC3), leukaemia (THP-1) and breast (MCF-7) cancer.
Venous occlusion plethysmography in patients with post-thrombotic venous claudication.
Blomgren et al., Stockholm, Sweden. In J Vasc Surg, 2013
Outflow volumes (OV1, OV4) and outflow fractions (OF1, OF4) were calculated at 1 and 4 seconds after cuff release.
Expression of phosphatase of regenerating liver family genes during embryogenesis: an evolutionary developmental analysis among Drosophila, amphioxus, and zebrafish.
Chen et al., Taiwan. In Bmc Dev Biol, 2012
BACKGROUND: Phosphatase of regenerating liver (PRL) family is classified as class IVa of protein tyrosine phosphatase (PTP4A) that removes phosphate groups from phosphorylated tyrosine residues on proteins.
Bauhinia variegata leaf extracts exhibit considerable antibacterial, antioxidant, and anticancer activities.
Pandey et al., Allahābād, India. In Biomed Res Int, 2012
AQ fraction of B. variegata showed pronounced cytotoxic effect against DU-145, HOP-62, IGR-OV-1, MCF-7, and THP-1 human cancer cell lines with 90-99% cell growth inhibitory activity.
Metastasis-associated phosphatase PRL-2 regulates tumor cell migration and invasion.
Lazo et al., Pittsburgh, United States. In Oncogene, 2012
Results suggest a model in which PRL-2 promotes cell migration and invasion through an ERK1/2-dependent signaling pathway.
Altered expression of phosphatase of regenerating liver gene family in non-small cell lung cancer.
Lee et al., Taejŏn, South Korea. In Oncol Rep, 2012
PRL-2 plays an important role in lung cancer and can be a biomarker of lung cancer, substituting for the function of other PRLs.
Overexpression of the protein tyrosine phosphatase PRL-2 correlates with breast tumor formation and progression.
Tremblay et al., Montréal, Canada. In Cancer Res, 2010
Overexpression of the protein tyrosine phosphatase PRL-2 correlates with breast tumor formation and progression.
PRL-2 increases Epo and IL-3 responses in hematopoietic cells.
Yi et al., Cleveland, United States. In Blood Cells Mol Dis, 2010
Mouse pre-B-cells transfected with human PRL-2 had higher growth responses to Epo or IL-3, shorter cell cycle, less Epo requirement for survival, more cell migration, less cell adhesion, change to an immature cell morphology, & more Bmi-1 expression.
[Construction of an eukaryotic expression vector for PRL-2 and its effect on human hepatocellular carcinoma cell invasiveness and migration in vitro].
Wen et al., Guangzhou, China. In Nan Fang Yi Ke Da Xue Xue Bao, 2007
PRL-2 can promote cell adhesion and invasion activity of human hepatocellular carcinoma cells.
PRL phosphatases as potential molecular targets in cancer.
Von Hoff et al., Tucson, United States. In Mol Cancer Ther, 2005
The phosphatase of regenerating liver (PRL) family of phosphatases, consisting of PRL-1, PRL-2, and PRL-3, represents an intriguing group of proteins being validated as biomarkers and therapeutic targets in cancer.
Gas-liquid chromatographic retention indices of 1318 substances of toxicological interest on SE-30 or OV-1 stationary phase.
Moffat et al., In J Chromatogr, 1982
Retention indices associated with 1318 substances likely to be encountered in toxicological analyses are presented.
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