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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Orthodenticle homolog 1

This gene encodes a member of the bicoid subfamily of the paired homeobox transcription factor family. The encoded protein is critical to the maintenance and regionalization of the forebrain and midbrain during development. It may also have important functions in sense organ development, pituitary function, and in the regulation of blood cell production. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Otx2, CAN, CRX, Meis1, AGE
Papers on Otx1
Induction of Functional 3D Ciliary Epithelium-Like Structure From Mouse Induced Pluripotent Stem Cells.
Takahashi et al., Nagasaki, Japan. In Invest Ophthalmol Vis Sci, Feb 2016
Connexin43 and aquaporin1 were expressed in both thin layers, and induced CE-like cells expressed ciliary marker genes, such as cyclinD2, zic1, tgfb2, aldh1a3, wfdc1, otx1, BMP4, and BMP7.
OTX2 regulates the expression of TAp63 leading to macular and cochlear neuroepithelium development.
Terrinoni et al., Roma, Italy. In Aging (albany Ny), Nov 2015
OTX proteins, homologs of the Drosophila orthodenticle (Otd), are important for the morphogenesis of the neuroectoderm, and for the central nervous system formation.
Evaluation of an Epigenetic Profile for the Detection of Bladder Cancer in Patients with Hematuria.
Van Criekinge et al., Maastricht, Netherlands. In J Urol, Sep 2015
SNaPshot™ methylation analysis was done for different loci of OTX1 and ONECUT2.
Co-expression of the transcription factors CEH-14 and TTX-1 regulates AFD neuron-specific genes gcy-8 and gcy-18 in C. elegans.
Kohara et al., Mishima, Japan. In Dev Biol, Apr 2015
In this study, we showed that AFD-specific expression of gcy-8 and gcy-18 requires the co-expression of homeodomain proteins, CEH-14/LHX3 and TTX-1/OTX1.
Aberrantly Expressed OTX Homeobox Genes Deregulate B-Cell Differentiation in Hodgkin Lymphoma.
MacLeod et al., Braunschweig, Germany. In Plos One, 2014
Our data demonstrate that OTX1 and OTX2 are aberrantly expressed in both HL patients and cell lines.
Deterministic progenitor behavior and unitary production of neurons in the neocortex.
Shi et al., New York City, United States. In Cell, 2014
Removal of OTX1, a transcription factor transiently expressed in RGPs, results in both deep- and superficial-layer neuron loss and a reduction in neuronal unit size.
Amplification of 2p as a genomic marker for transformation in lymphoma.
Lagercrantz et al., Sweden. In Genes Chromosomes Cancer, 2014
Gain of 2p15-16.1 encompassing, among others, the REL, BCL11A, USP34, COMMD1, and OTX1 genes was found to be more common in the tDLBCL compared with dnDLBCL (P < 0.001).
OTX1 promotes colorectal cancer progression through epithelial-mesenchymal transition.
Li et al., Kunming, China. In Biochem Biophys Res Commun, 2014
Orthodenticle homeobox 1 (OTX1), a transcription factor containing a bicoid-like homeodomain, plays a role in brain and sensory organ development.
Genitourinary defects associated with genomic deletions in 2p15 encompassing OTX1.
Lamb et al., Edmonton, Canada. In Plos One, 2013
These deletions encompass the transcription factor OTX1. Subjects 2-7 had large de novo CNVs (2.39-6.31
Identification and evolution of molecular domains involved in differentiating the cement gland-promoting activity of Otx proteins in Xenopus laevis.
Vignali et al., Pisa, Italy. In Mech Dev, 2013
Otx genes are a class of vertebrate homeobox genes, homologous to the orthodenticle gene of Drosophila melanogaster, that play a crucial role in anterior embryo patterning and sensory organ formation.
Novel gene expression model for outcome prediction in paediatric medulloblastoma.
Liberski et al., Łódź, Poland. In J Mol Neurosci, 2013
We evaluated the transcriptional level of the ATOH1, FUT4, NGFR, OTX1, OTX2, PROM1 and SOX1 genes in 48 samples of medulloblastoma and analysed their usefulness in the prediction of disease outcome.
The use of molecular analyses in voided urine for the assessment of patients with hematuria.
Zwarthoff et al., Rotterdam, Netherlands. In Plos One, 2012
Urine DNA was analyzed for methylation of OSR1, SIM2, OTX1, MEIS1 and ONECUT2.
Transcriptome comparison of human neurons generated using induced pluripotent stem cells derived from dental pulp and skin fibroblasts.
Lachman et al., New York City, United States. In Plos One, 2012
In addition, an increased level of expression was seen for several transcription factors expressed in the developing forebrain (FOXP2, OTX1, and LHX2, for example).
2p15-p16.1 microdeletion syndrome: molecular characterization and association of the OTX1 and XPO1 genes with autism spectrum disorders.
Holden et al., Kingston, Canada. In Eur J Hum Genet, 2011
XPO1 and OXT1 may contribute to ASD in 2p15-p16.1 deletion cases and non-deletion cases of ASD mapping to this chromosome region.
OTX1 expression in breast cancer is regulated by p53.
Porta et al., Roma, Italy. In Oncogene, 2011
established that the p53 protein directly induces OTX1 expression by acting on its promoter
Conserved and non-conserved enhancers direct tissue specific transcription in ancient germ layer specific developmental control genes.
Lufkin et al., Singapore, Singapore. In Bmc Dev Biol, 2010
Foxa1 binds to the otx1b non-conserved enhancer to direct its activity in forebrain and otic vesicle of zebrafish at 24 hpf.
Otx2 and Otx1 protect diencephalon and mesencephalon from caudalization into metencephalon during early brain regionalization.
Aizawa et al., Kōbe, Japan. In Dev Biol, 2010
the medial pallium requires Otx1 and Otx2 for its development later than E9.5, and the Otx2 expression in diencepalon and mesencephalon later than E9.5 is also directed by an enhancer other than FM1 and FM2 enhancers
Expression of the homeobox genes OTX2 and OTX1 in the early developing human brain.
Møller et al., Copenhagen, Denmark. In J Histochem Cytochem, 2010
The early expression of OTX1 in proliferative cell layers of the human fetal brain supports the concept that this homeobox gene is important in neuronal cell development and differentiation.
The Otx family.
Acampora et al., London, United Kingdom. In Curr Opin Genet Dev, 2002
Otx1 and Otx2, the murine homologs of the Drosophila orthodenticle gene, play a remarkable role in specification and regionalization of forebrain and midbrain.
Otx genes in evolution: are they involved in instructing the vertebrate brain morphology?
Simeone et al., London, United Kingdom. In J Anat, 2001
Previous mouse models have indicated that Otx1 and Otx2 play an important role in brain and sense organ development and, together with the Drosophila orthodenticle (otd) gene, they share a high degree of reciprocal functional equivalence.
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