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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Secreted phosphoprotein 1

osteopontin, OPN, BSP
The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: CAN, Osteocalcin, HAD, V1a, Runx2
Papers using osteopontin antibodies
Modulation of calcium oxalate dihydrate growth by selective crystal-face binding of phosphorylated osteopontin and polyaspartate peptide showing occlusion by sectoral (compositional) zoning
Supplier
Yang Ru-E et al., In International Journal of Nanomedicine, 2008
... The primary antibody of osteopontin (OPN) and fluorescein isothiocyanate secondary antibody were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Prognostic and predictive importance of p53 and RAS for adjuvant chemotherapy in non small-cell lung cancer
Supplier
Kraynov Eugenia et al., In Journal of Experimental & Clinical Cancer Research : CR, 2006
... Reaction mixture supernatant was removed and analyzed by SDS-PAGE and western blot using a mouse anti-human OPN antibody (34E3, IBL, Japan) specific to the ...
Osteocyte dendrogenesis in static and dynamic bone formation: an ultrastructural study
Supplier
De Pol A. et al., In European Journal of Histochemistry : EJH, 2003
... Rabbit anti-c-Kit; mouse IgM anti-STRO-1; Mouse anti-OPN;Santa Cruz Biotechnology, Santa Cruz, CA, USA ...
Role of DNA methylation in the suppression of Apaf-1 protein in human leukaemia
Supplier
Lee Horng-Mo et al., In Neuro-Oncology, 2002
... Anti-OPN and anti-α-tubulin antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, California) ...
Time-dependent ultrastructural changes to porcine stratum corneum following an electric pulse
Supplier
Chang Kang-Ming et al., In International Journal of Nanomedicine, 1998
... Osteopontin (molecular weight 33 kDa) was purchased from Acris Antibodies (San Diego, CA) ...
Papers on osteopontin
Monolithic calcium phosphate/poly(lactic acid) composite versus calcium phosphate-coated poly(lactic acid) for support of osteogenic differentiation of human mesenchymal stromal cells.
New
Habibovic et al., Enschede, Netherlands. In J Mater Sci Mater Med, Mar 2016
Enzymatic alkaline phosphatase activity as well as the mRNA expression of bone morphogenetic protein-2, osteopontin and osteocalcin were higher on the composite and coated polymer as compared to the PLA control, while no significant differences were observed between the two methods of combining CaP and PLA.
Serum Biomarkers of Allergic Contact Dermatitis: A Pilot Study.
New
Girkontaitė et al., Vilnius, Lithuania. In Int Arch Allergy Immunol, Feb 2016
RESULTS: Serum levels of adiponectin, chemokine (C-C motif) ligand 5 (CCL5), C-reactive protein (CRP), chitinase 3-like 1 (CHI3L1), complement factor D (CFD), endoglin, lipocalin-2, osteopontin, retinol-binding protein 4 (RBP4), and platelet factor 4 (PF4) were significantly higher, whereas levels of trefoil factor 3 (TFF3) were significantly lower, in ACD patients than in healthy controls.
Structure-function relationships in Thrombin-activatable Fibrinolysis Inhibitor.
Review
New
Meijers et al., Amsterdam, Netherlands. In J Thromb Haemost, Feb 2016
TAFI also plays a role in inflammatory processes via the removal of C-terminal arginine or lysine residues from bradykinin, thrombin-cleaved osteopontin, C3a, C5a and chemerin.
Enhanced osseointegration of hierarchical micro/nano-topographic titanium fabricated by micro-arc oxidation and electrochemical treatment.
New
Jiang et al., In Acs Appl Mater Interfaces, Feb 2016
In addition, the expression levels of osteogenesis-related genes, osteorix, ALP, OPN, and OCN, in the canine BMSCs were all up-regulated after incubation on these coatings, especially on the MAO-AK coating.
Enhanced healing of surgical periodontal defects in rats following application of a self-assembling peptide nanofiber hydrogel.
New
Saito et al., Tokyo, Japan. In J Clin Periodontol, Feb 2016
Expression levels of PCNA-positive cells, vascular endothelial growth factor and osteopontin in the RADA16 group were significantly greater than those in other groups.
Restoration of Visual Function by Enhancing Conduction in Regenerated Axons.
New
Impact
He et al., Boston, United States. In Cell, Feb 2016
Here, in both juvenile and adult mice, we show that either PTEN and SOCS3 co-deletion, or co-overexpression of osteopontin (OPN)/insulin-like growth factor 1 (IGF1)/ciliary neurotrophic factor (CNTF), induces regrowth of retinal axons and formation of functional synapses in the superior colliculus (SC) but not significant recovery of visual function.
The role of the SIBLING, Bone Sialoprotein in skeletal biology - Contribution of mouse experimental genetics.
Review
New
Malaval et al., Saint-Priest, France. In Matrix Biol, Feb 2016
BSP has been less studied than other SIBLING proteins such as Osteopontin (OPN), which is coexpressed with it in several skeletal cell types.
Pharmacotherapy of alcoholic liver disease in clinical practice.
Review
New
Persico et al., Napoli, Italy. In Int J Clin Pract, Jan 2016
While in aggressive forms of alcoholic hepatitis are recommended specific drug treatments, including glucocorticoids or pentoxifylline, for the long-term treatment of ALD, specific treatments aimed at stopping the progression of fibrosis are not yet approved, but there are some future perspective in this field, including probiotics and antibiotics, caspase inhibitors, osteopontin and endocannabinoids.
Current and future biomarkers in allergic asthma.
Review
New
Schmidt-Weber et al., München, Germany. In Allergy, Jan 2016
Eosinophilic and neutrophilic asthma endotypes are also classified by epithelium-derived CCL-26 and osteopontin, respectively.
A p85α-osteopontin axis couples the receptor ICOS to sustained Bcl-6 expression by follicular helper and regulatory T cells.
Impact
Cantor et al., Boston, United States. In Nat Immunol, 2015
Here we report that activation of ICOS in CD4(+) T cells promoted interaction of the p85α regulatory subunit of the signaling kinase PI(3)K and intracellular osteopontin (OPN-i), followed by translocation of OPN-i to the nucleus, its interaction with Bcl-6 and protection of Bcl-6 from ubiquitin-dependent proteasome degradation.
Polymorphism of the osteopontin gene and clinical course of multiple sclerosis in the Polish population.
Wender et al., Poznań, Poland. In Folia Neuropathol, 2014
Osteopontin (OPN) is a key cytokine involved in T-cell activation in multiple sclerosis (MS).
Role of Irisin on the bone-muscle functional unit.
Review
Grano et al., Bari, Italy. In Bonekey Rep, 2014
Low-dose r-Irisin also increases osteopontin and decreases sclerostin synthesis but did not affect Uncoupling protein 1 expression in white adipose tissue, whose upregulation is known to cause browning of fat, when Irisin is administered at a higher dose.
Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth.
Impact
Holland et al., Seattle, United States. In Cell Stem Cell, 2014
The CD44 ligand osteopontin shared a perivascular expression pattern with CD44 and promoted glioma stem cell-like phenotypes.
CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis.
Impact
Stassi et al., Palermo, Italy. In Cell Stem Cell, 2014
Cytokines hepatocyte growth factor (HGF), osteopontin (OPN), and stromal-derived factor 1α (SDF-1), secreted from tumor associated cells, increase CD44v6 expression in CR-CSCs by activating the Wnt/β-catenin pathway, which promotes migration and metastasis.
Identification of an adipogenic niche for adipose tissue remodeling and restoration.
Impact
Granneman et al., Detroit, United States. In Cell Metab, 2013
Recruited macrophages express high levels of osteopontin (OPN), which attracts a subpopulation of PDGFRα+ progenitors expressing CD44, a receptor for OPN.
Vascular endothelial growth factor-induced osteopontin expression mediates vascular inflammation and neointima formation via Flt-1 in adventitial fibroblasts.
GeneRIF
Gao et al., Shanghai, China. In Arterioscler Thromb Vasc Biol, 2012
VEGF/Flt-1 signaling plays a significant role in vascular inflammation and neointima formation by regulating osteopontin expression in vascular adevntitial fibroblasts.
Osteopontin is upregulated after mechanical brain injury and stimulates neurite growth from hippocampal neurons through β1 integrin and CD44.
GeneRIF
Plantman, Stockholm, Sweden. In Neuroreport, 2012
findings indicate that injury-induced osteopontin may support neurite sprouting, suggesting a role for this molecule in recovery from central nervous system trauma
Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells.
GeneRIF
Bird et al., Edinburgh, United Kingdom. In Genes Dev, 2012
The results demonstrated that Cfp1 is a specificity factor that integrates multiple signals, including promoter CpG content and gene activity, to regulate genome-wide patterns of H3K4me3.
Importance of SPP1 genotype as a covariate in clinical trials in Duchenne muscular dystrophy.
GeneRIF
Pegoraro et al., Padova, Italy. In Neurology, 2012
SPP1 genotype is a disease modifier in Duchenne muscular dystrophy.
OPN gene polymorphisms are associated with susceptibility and clinicopatholigical characteristics of cervical cancer in a Chinese cohort.
GeneRIF
Yue et al., Tianjin, China. In Cancer Biomark, 2010
the -156 GG/G and -443T/C polymorphisms of Osteopontin (OPN) might be used as a genetic marker for cervical cancer susceptibility.
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