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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Secreted protein, acidic, cysteine-rich

osteonectin
This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: Osteocalcin, osteopontin, CAN, HAD, ACID
Papers on osteonectin
MicroRNA variants as genetic determinants of bone mass.
Review
New
Delany et al., Farmington, United States. In Bone, Jan 2016
SNPs in miRNA targeting sites (miR-TS-SNPs) that alter miRNA binding are described for the bone remodeling genes bone morphogenetic protein receptor 1 (Bmpr1), fibroblast growth factor 2 (Fgf2), osteonectin (Sparc) and histone deacetylase 5 (Hdac5).
Curcumin alleviates glucocorticoid-induced osteoporosis through the regulation of the Wnt signaling pathway.
New
Fu et al., Shenyang, China. In Int J Mol Med, Jan 2016
This study aimed to evaluate the protective effects of curcumin on the bones of rats with dexamethasone (DXM)-induced osteoporosis.
Demineralized Dentin Matrix Induces Odontoblastic Differentiation of Dental Pulp Stem Cells.
New
Wang et al., Beijing, China. In Cells Tissues Organs, Dec 2015
The aim of this study was to investigate the effect of demineralized dentin matrix (DDM) on dental pulp stem cells (DPSCs) and the potential of complexes with DPSCs and DDM for mineralized tissue formation.
High mobility group box 1-induced epithelial mesenchymal transition in human airway epithelial cells.
New
Lee et al., Taiwan. In Sci Rep, Dec 2015
The top five upregulated genes were SNAI2, FGFBP1, VIM, SPARC (osteonectin), and SERPINE1, while the downregulated genes included OCLN, TJP1 (ZO-1), FZD7, CDH1 (E-cadherin), and LAMA5.
Synergistic interaction of platelet derived growth factor (PDGF) with the surface of PLLA/Col/HA and PLLA/HA scaffolds produces rapid osteogenic differentiation.
New
Kamarul et al., Kuala Lumpur, Malaysia. In Colloids Surf B Biointerfaces, Dec 2015
In comparison with PLLA/Col, the PLLA/Col/HA and PLLA/HA scaffolds presented a significant upregulation of the genes Runx2, Col 1, Integrin, osteonectin (ON), bone gamma-carboxyglutamic acid-containing protein (BGALP), osteopontin (OPN), and BMP2.
Secreted Protein Acidic and Rich in Cysteine in Ocular Tissue.
Review
New
Rhee et al., Cleveland, United States. In J Ocul Pharmacol Ther, Sep 2015
Secreted protein acidic and rich in cysteine (SPARC), also known as osteonectin or BM-40, is the prototypical matricellular protein.
The Function of Matricellular Proteins in the Lamina Cribrosa and Trabecular Meshwork in Glaucoma.
Review
New
O'Brien et al., Dublin, Ireland. In J Ocul Pharmacol Ther, Sep 2015
METHODS: A literature search was performed for published articles describing the expression and function of matricellular proteins such as thrombospondin (TSP), connective tissue growth factor (CTGF), secreted protein acidic and rich in cysteine (SPARC), and periostin in glaucoma.
Tracheal Aspirate Levels of the Matricellular Protein SPARC Predict Development of Bronchopulmonary Dysplasia.
Hershenson et al., Ann Arbor, United States. In Plos One, 2014
Tracheal aspirate and MSC-conditioned media were analyzed for seven matricellular proteins including SPARC (for Secreted Protein, Acidic, Rich in Cysteine, also called osteonectin) and normalized to secretory component of IgA.
Is Pulp Inflammation a Prerequisite for Pulp Healing and Regeneration?
Review
Uzunoglu et al., Paris, France. In Mediators Inflamm, 2014
Pulp fibroblasts become odontoblast-like cells producing type I collagen, alkaline phosphatase, and SPARC/osteonectin.
Primary Epithelioid Angiosarcoma of Bone with Robust Cell Cycle Progression and High Expression of SPARC: A Case Report and Review of the Literature.
Review
Yan et al., Houston, United States. In Ann Clin Lab Sci, 2014
Secreted protein acidic and rich in cysteine (SPARC), or osteonectin, is a secreted glycoprotein that has been implicated in tumorigenesis.
Baseline Serum Osteopontin Levels Predict the Clinical Effectiveness of Tocilizumab but Not Infliximab in Biologic-Naïve Patients with Rheumatoid Arthritis: A Single-Center Prospective Study at 1 Year (the Keio First-Bio Cohort Study).
Takeuchi et al., Tokyo, Japan. In Plos One, 2014
We assessed baseline variables including patients' characteristics (age, sex, disease duration, prednisolone dose, methotrexate dose, other disease-modifying antirheumatic drug use, Clinical Disease Activity Index [CDAI]) and serum biomarker levels (C-reactive protein, immunoglobulin M-rheumatoid factor, anti-cyclic citrullinated protein/peptide antibodies, interferon-γ, interleukin (IL)-1β, IL-2, IL-6, IL-8, IL-10, IL-17, tumor necrosis factor-α, soluble intercellular adhesion molecule-1, bone alkaline phosphatase, osteonectin, osteopontin) to extract factors associated with clinical remission (CDAI≤2.8) at 1 year using univariate analyses, and the extracted factors were entered into a multivariate logistic regression model.
The utility of biomarker risk prediction score in patients with chronic heart failure.
Kruzliak et al., Ukraine. In Int J Clin Exp Med, 2014
METHODS: A prospective study on the incidence of fatal and non-fatal cardiovascular events, as well as the frequency of occurrence of death from any cause in a cohort of 388 patients with CHF during 3 years of observation was performed.
Blockade of SOX4 mediated DNA repair by SPARC enhances radioresponse in medulloblastoma.
GeneRIF
Lakka et al., Peoria, United States. In Cancer Lett, 2012
demonstrate that SPARC expression suppressed irradiation induced SOX-4 mediated DNA repair
SPARC promotes the development of erythroid progenitors.
GeneRIF
Cheng et al., Changsha, China. In Exp Hematol, 2012
SPARC promotes the development of erythroid progenitors, but does not affect terminal erythroid differentiation.
Aberrant methylation of SPARC in human hepatocellular carcinoma and its clinical implication.
GeneRIF
Bai et al., Tianjin, China. In World J Gastroenterol, 2012
Aberrant methylation is an important mechanism for SPARC inactivation in hepatocellular carcinoma (HCC) and SPARC methylation may be a promising biomarker for the diagnosis and prognosis of HCC.
Pax6 interacts with SPARC and TGF-β in murine eyes.
GeneRIF
Mishra et al., Benares, India. In Mol Vis, 2011
SPARC influences the shuttling of Pax6 via the TGF-beta/Smad signaling pathway.
SPARC overexpression inhibits cell proliferation in neuroblastoma and is partly mediated by tumor suppressor protein PTEN and AKT.
GeneRIF
Rao et al., Peoria, United States. In Plos One, 2011
Results establish SPARC as an effector of AKT-PTEN-mediated inhibition of proliferation in neuroblastoma in vitro and in vivo.
Expression and function of laminins in the embryonic and mature vasculature.
Review
Impact
Sorokin et al., Lund, Sweden. In Physiol Rev, 2005
Other extracellular matrix molecules, such as BM40 (also known as SPARC/osteonectin), thrombospondins 1 and 2, fibronectin, nidogens 1 and 2, and collagen types VIII, XV, and XVIII, are also differentially expressed by endothelium, varying with the endothelium type and/or pathophysiological state.
Three-dimensional cellular development is essential for ex vivo formation of human bone.
Impact
Long et al., Ann Arbor, United States. In Nat Biotechnol, 2000
In turn, bone cell spheroid formation results in the up-regulation of several bone-related proteins (e.g., alkaline phosphatase, type I collagen, osteonectin) during days 3-7, and the concomitant formation of micro-crystalline bone.
Osteonectin, a bone-specific protein linking mineral to collagen.
Impact
Martin et al., In Cell, 1981
Osteonectin is a 32,000 dalton bone-specific protein that binds selectively to both hydroxyapatite and collagen.
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