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C-type lectin domain family 2, member D

osteoclast inhibitory lectin, OCIL, LLT1, CLEC2D, lectin-like transcript-1, Clr-b
This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: CD161, MHC, Pia, CAN, CD69
Papers on osteoclast inhibitory lectin
Lectin-like transcript 1 is a marker of germinal center-derived B-cell non-Hodgkin's lymphomas dampening natural killer cell functions.
New
Braud et al., France. In Oncoimmunology, Aug 2015
Here, we identified Lectin-like transcript 1 (LLT1) as a biomarker of germinal center (GC)-derived B-cell NHLs.
Crystal structure of extracellular domain of human lectin-like transcript 1 (LLT1), the ligand for natural killer receptor-P1A.
New
Maenaka et al., Sapporo, Japan. In Eur J Immunol, Jun 2015
Human natural killer cell receptor-P1A (NKRP1A) is one of the CTLRs and recognizes another CTLR, lectin-like transcript 1 (LLT1) on target cells to control NK, NKT and Th17 cells.
Expression and purification of soluble and stable ectodomain of natural killer cell receptor LLT1 through high-density transfection of suspension adapted HEK293S GnTI(-) cells.
New
Vaněk et al., Praha, Czech Republic. In Protein Expr Purif, May 2015
Lectin-like transcript 1 (LLT1, gene clec2d) was identified to be a ligand for the single human NKR-P1 receptor present on NK and NK-T lymphocytes.
The mouse NKR-P1B:Clr-b recognition system is a negative regulator of innate immune responses.
New
Makrigiannis et al., Ottawa, Canada. In Blood, May 2015
NKR-P1B is a homodimeric type II transmembrane C-type lectinlike receptor that inhibits natural killer (NK) cell function upon interaction with its cognate C-type lectin-related ligand, Clr-b.
Genetic investigation of MHC-independent missing-self recognition by mouse NK cells using an in vivo bone marrow transplantation model.
New
Carlyle et al., Toronto, Canada. In J Immunol, Apr 2015
In this study, we investigated the role of NKR-P1B:Clr-b (Klrb1:Clec2d) interactions in determining the outcome of murine hematopoietic cell transplantation in vivo.
Four crystal structures of human LLT1, a ligand of human NKR-P1, in varied glycosylation and oligomerization states.
New
Dohnálek et al., Praha, Czech Republic. In Acta Crystallogr D Biol Crystallogr, Mar 2015
Human LLT1 is a C-type lectin-like ligand of NKR-P1 (CD161, gene KLRB1), a C-type lectin-like receptor of natural killer cells.
A 2.5-kilobase deletion containing a cluster of nine microRNAs in the latency-associated-transcript locus of the pseudorabies virus affects the host response of porcine trigeminal ganglia during established latency.
Giuffra et al., Jouy-le-Moutier, France. In J Virol, 2015
All PrV miRNAs were expressed, with highest expression observed for prv-miR-LLT1, prv-miR-LLT2 (in WT ganglia), and prv-miR-LLT10 (in both WT and M ganglia).
Modulation of Clr Ligand Expression and NKR-P1 Receptor Function during Murine Cytomegalovirus Infection.
Carlyle et al., Toronto, Canada. In J Innate Immun, 2014
Here, we characterize an MHC-I-independent natural killer (NK) cell recognition mechanism that involves modulation of inhibitory NKR-P1B:Clr-b receptor-ligand interactions in response to mouse cytomegalovirus (MCMV) infection.
The c.503T>C Polymorphism in the Human KLRB1 Gene Alters Ligand Binding and Inhibitory Potential of CD161 Molecules.
Schwinzer et al., Hannover, Germany. In Plos One, 2014
c.503T>C causes an amino acid exchange (p.Ile168Thr) in an extracellular loop of the CD161 receptor, which is regarded to be involved in binding of its ligand Lectin-like transcript 1 (LLT1).
Expression of Lectin-Like Transcript 1, the Ligand for CD161, in Rheumatoid Arthritis.
Boots et al., Groningen, Netherlands. In Plos One, 2014
The endogenous ligand for CD161 is lectin-like transcript 1 (LLT1).
OCILRP2 signaling synergizes with LPS to induce the maturation and differentiation of murine dendritic cells.
Ma et al., Zhengzhou, China. In Biochem Biophys Res Commun, 2014
Osteoclast Inhibitory Lectin-related Protein 2 (OCILRP2) is a typical type II transmembrane protein and belongs to C-type lectin-related protein family.
Respiratory syncytial virus infection, TLR3 ligands, and proinflammatory cytokines induce CD161 ligand LLT1 expression on the respiratory epithelium.
Culley et al., London, United Kingdom. In J Virol, 2014
We asked whether the CD161 ligand LLT1 could be expressed on respiratory epithelial cells following respiratory-virus infection as a mechanism by which respiratory-virus infection could promote activation of proinflammatory lymphocytes.
Different genetic associations of the IgE production among fetus, infancy and childhood.
Yang et al., Kao-hsiung, Taiwan. In Plos One, 2012
The combination of IL13, CYFIP2 and PDE2A was significantly associated with IgE elevation at 3 years of age (P=5.98 × 10(-7)), and the combination of CLEC2D, COLEC11 and CCL2 was significantly associated with IgE elevation at 6 years of age (P=6.65 × 10(-7)).
Modulation of NK cell function by genetically coupled C-type lectin-like receptor/ligand pairs encoded in the human natural killer gene complex.
Review
Steinle et al., Frankfurt am Main, Germany. In Front Immunol, 2012
Ligands of the human NKPR1 receptors are likewise C-type lectin-like glycoproteins belonging to the CLEC2 subfamily (i.e., LLT1, AICL, and KACL), and are encoded in the NKC in tight genetic linkage to their respective receptors.
Poxvirus infection-associated downregulation of C-type lectin-related-b prevents NK cell inhibition by NK receptor protein-1B.
GeneRIF
Burshtyn et al., Edmonton, Canada. In J Immunol, 2012
Reductions of Clr-b may be involved in sensitizing poxvirus-infected cells to natural killer (NK) cells.
Induction of lectin-like transcript 1 (LLT1) protein cell surface expression by pathogens and interferon-γ contributes to modulate immune responses.
GeneRIF
Braud et al., Antibes, France. In J Biol Chem, 2011
LLT1 and CD161 have roles in modulating immune responses to pathogens; and interferon-gamma contributes to modulate immune responses
Molecular basis for LLT1 protein recognition by human CD161 protein (NKRP1A/KLRB1).
GeneRIF
Maenaka et al., Sapporo, Japan. In J Biol Chem, 2011
Molecular basis for LLT1 protein recognition by human CD161 protein (NKRP1A/KLRB1).
Characterization of alternatively spliced transcript variants of CLEC2D gene.
GeneRIF
Braud et al., Antibes, France. In J Biol Chem, 2010
Data show that only CLEC2D isoform 1 (LLT1) is expressed on the cell surface.
LLT1-mediated activation of IFN-gamma production in human natural killer cells involves ERK signalling pathway.
GeneRIF
Mathew et al., Fort Worth, United States. In Scand J Immunol, 2010
LLT1 used Src-PTK, p38 and ERK signalling pathways, but not PKC, PI3K or calcineurin pathways, to increase production of IFN-gamma by human natural killer cells.
Cytomegalovirus evasion of innate immunity by subversion of the NKR-P1B:Clr-b missing-self axis.
Impact
Carlyle et al., Berlin, Germany. In Immunity, 2007
RCMV infection rapidly extinguished host Clr-b expression, thereby sensitizing infected cells to killing by natural killer (NK) cells.
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