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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Bone gamma-carboxyglutamate

Osteocalcin, BGP
highly conserved protein associated with mineralized bone matrix; protein is secreted by calcified tissues and is regulated by vitamin D3 [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: HAD, AGE, CAN, fibrillin-1, ACID
Papers on Osteocalcin
Isolation of acetic, propionic and butyric acid-forming bacteria from biogas plants.
König et al., Mainz, Germany. In J Biotechnol, Feb 2016
UNASSIGNED: In this study, acetic, propionic and butyric acid-forming bacteria were isolated from thermophilic and mesophilic biogas plants (BGP) located in Germany.
Different osteocalcin forms, markers of metabolic syndrome and anthropometric measures in children within the IDEFICS cohort.
IDEFICS consortium et al., Göteborg, Sweden. In Bone, Feb 2016
OBJECTIVE: Osteocalcin (OC), an aboundant non-collgenous bone protein, is inversely associated with parameters of glucose metabolism.
New insights into the biology of osteocalcin.
Riddle et al., Baltimore, United States. In Bone, Jan 2016
Osteocalcin is among the most abundant proteins in bone and is produced exclusively by osteoblasts.
Osteocalcin as a hormone regulating glucose metabolism.
Kanazawa, Japan. In World J Diabetes, Jan 2016
Accumulating evidence has shown that osteocalcin, which is specifically expressed in osteoblasts and secreted into the circulation, regulates glucose homeostasis by stimulating insulin expression in pancreas and adiponectin expression in adipocytes, resulting in improving glucose intolerance.
Murine GPRC6A Mediates Cellular Responses to L-Amino Acids, but Not Osteocalcin Variants.
Langmead et al., Australia. In Plos One, Dec 2015
Such effects are described as mediated by extracellular calcium, L-amino acids, the bone-derived peptide osteocalcin (OCN) and the male hormone testosterone, introducing the concept of a bone-energy-metabolism-reproduction functional crosstalk mediated by GPRC6A.
Association between Serum Total Osteocalcin Level and Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.
Zhao et al., Qingdao, China. In Horm Metab Res, Oct 2015
Studies on the association between serum total osteocalcin level and type 2 diabetes mellitus (T2DM) had reported controversial results.
Metaproteomics of complex microbial communities in biogas plants.
Benndorf et al., Magdeburg, Germany. In Microb Biotechnol, Sep 2015
In the following, the workflow and potential pitfalls for metaproteomics of samples from full-scale BGP are discussed.
Bone Regulates Glucose Metabolism as an Endocrine Organ through Osteocalcin.
Liu et al., Shanghai, China. In Int J Endocrinol, 2014
Besides osteoprotegerin (OPG), sclerostin (SOST), and Dickopf (DKK) which play essential roles in bone formation, modelling, remodelling, and homeostasis, bone can also secret hormones, such as osteocalcin (OCN), which promotes proliferation of β cells, insulin secretion, and insulin sensitivity.
Berberine in Combination with Insulin Has Additive Effects on Titanium Implants Osseointegration in Diabetes Mellitus Rats.
Zhimin et al., Chengdu, China. In Evid Based Complement Alternat Med, 2014
Serum levels of alkaline phosphatase (ALP) and bone gamma-carboxyglutamic acid-containing protein (BGP) were analyzed in each group.
A Vitamin D-Calcium-Fortified Yogurt Drink Decreased Serum PTH but did not Affect Osteocalcin in Subjects with Type 2 Diabetes.
Shariatzadeh et al., Tehrān, Iran. In Int J Vitam Nutr Res, 2014
Anthropometric and biochemical assessments were made, including 25(OH), intact parathyroid hormone (iPTH), osteocalcin, and calcium.
Maternal and offspring pools of osteocalcin influence brain development and functions.
Karsenty et al., New York City, United States. In Cell, 2013
We show here that the osteoblast-derived hormone osteocalcin crosses the blood-brain barrier, binds to neurons of the brainstem, midbrain, and hippocampus, enhances the synthesis of monoamine neurotransmitters, inhibits GABA synthesis, prevents anxiety and depression, and favors learning and memory independently of its metabolic functions.
Osteocalcin is independently associated with body mass index in adolescent girls.
Constantini et al., Ramat Gan, Israel. In Pediatr Obes, 2012
In female adolescents, BMI is inversely related to osteocalcin.
From skeleton to cytoskeleton: osteocalcin transforms vascular fibroblasts to myofibroblasts via angiotensin II and Toll-like receptor 4.
Huang et al., Hong Kong, Hong Kong. In Circ Res, 2012
Skeletal hormone osteocalcin cross-talks with vascular system and contributes to vascular remodeling via angiotensin II, Toll-like receptor (TLR)4, and cyclooxygenase (COX)-2.
Conditional expression of human bone Gla protein in osteoblasts causes skeletal abnormality in mice.
Inoue et al., Saitama, Japan. In Biochem Biophys Res Commun, 2012
These findings indicate that hBGP expression in osteoblasts resulted in the abnormal skeletal growth in the mice.This study provides a valuable model for understanding the fundamental role of BGP in vivo.
Bone delivers its energy information to fat and islets through osteocalcin.
Yu et al., Chengdu, China. In Orthop Surg, 2012
Metabolic activity of bone and energy-related organs like fat and islets are closely linked by circulating osteocalcin (OCN). Through systemic release of OCN, bone delivers its energy-demanding information to other organs to satisfy its energy requirement
Hsp72 preserves muscle function and slows progression of severe muscular dystrophy.
Lynch et al., Melbourne, Australia. In Nature, 2012
Treatment with BGP-15 (a pharmacological inducer of Hsp72 currently in clinical trials for diabetes) improved muscle architecture, strength and contractile function in severely affected diaphragm muscles in mdx dystrophic mice.
The expression and modulation of CEACAM1 and tumor cell transformation.
Cianfriglia et al., Fano, Italy. In Ann Ist Super Sanita, 2011
Restoration of CEACAM1 expression in tumor cell lines often abolishes their oncogenicity. De novo expression of CEACAM1 is found with the progression of malignancy and metastatic spread in a large array of cancer tissues. Review.
Endocrine regulation of energy metabolism by the skeleton.
Karsenty et al., New York City, United States. In Cell, 2007
In contrast, mice lacking the osteoblast-secreted molecule osteocalcin display decreased beta-cell proliferation, glucose intolerance, and insulin resistance.
Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial.
Memantine Study Group et al., Rochester, United States. In Jama, 2004
Secondary outcomes included a Clinician's Interview-Based Impression of Change Plus Caregiver Input (CIBIC-Plus), the Neuropsychiatric Inventory, and the Behavioral Rating Scale for Geriatric Patients (BGP Care Dependency Subscale).
Bone recognition mechanism of porcine osteocalcin from crystal structure.
Yang et al., Hamilton, Canada. In Nature, 2003
Osteocalcin is the most abundant noncollagenous protein in bone, and its concentration in serum is closely linked to bone metabolism and serves as a biological marker for the clinical assessment of bone disease.
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