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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Odd-skipped related 2

Osr2, Odd-skipped related 2, Osr2A
OSR2 is a mammalian homolog of the Drosophila odd-skipped family of transcription factors (Lan et al., 2004 [PubMed 15175245]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: ODD, OSR1, BMP4, MSX1, Fibroblast Growth Factor 10
Papers on Osr2
The function and interrelationship between GDF5 and ERG-010 during chondrogenesis in vitro.
Wallis et al., Pittsburgh, United States. In In Vitro Cell Dev Biol Anim, Dec 2015
Microarray analysis following Erg-010 overexpression identified two potential downstream targets, Ube2b and Osr2, which were also differentially regulated by GDF5.
Disruption of the ERK/MAPK pathway in neural crest cells as a potential cause of Pierre Robin sequence.
Chai et al., Los Angeles, United States. In Development, Dec 2015
To understand the function of ERK2 (MAPK1) in the postmigratory neural crest populating the craniofacial region, we studied two mouse models: Wnt1-Cre;Erk2(fl/fl) and Osr2-Cre;Erk2(fl/fl). Wnt1-Cre;Erk2(fl/fl) mice exhibited cleft palate, malformed tongue, micrognathia and mandibular asymmetry.
Regulatory variant in FZD6 gene contributes to nonsyndromic cleft lip and palate in an African-American family.
Hecht et al., Houston, United States. In Mol Genet Genomic Med, Sep 2015
This region contained four genes, Frizzled-6 (FZD6), Matrilin-2 (MATN2), Odd-skipped related 2 (OSR2) and Solute Carrier Family 25, Member 32 (SLC25A32).
Deletion of Osr2 Partially Rescues Tooth Development in Runx2 Mutant Mice.
Jiang et al., Cincinnati, United States. In J Dent Res, Aug 2015
Recent studies identified Osr2 as a repressor of tooth development and showed that inactivation of Osr2 rescued molar tooth morphogenesis in the Msx1(-/-) mutant mice as well as in mice with neural crest-specific inactivation of Bmp4.
Identification of the genes regulated by Wnt-4, a critical signal for commitment of the ovary.
Vainio et al., Oulu, Finland. In Exp Cell Res, Apr 2015
We used the Wnt-4 deficient mouse as a model to identify candidate gonadogenesis genes, and found that the Notum, Phlda2, Runx-1 and Msx1 genes are typical of the wild-type ovary and the Osr2, Dach2, Pitx2 and Tacr3 genes of the testis.
Establishment of a DNA methylation marker to evaluate cancer cell fraction in gastric cancer.
Ushijima et al., Tokyo, Japan. In Gastric Cancer, Mar 2015
RESULTS: Genome-wide DNA methylation analysis of 12 GC cell lines, 30 GCs, six normal gastric mucosae, one sample of peripheral leukocytes, and four noncancerous gastric mucosae identified OSR2, PPFIA3, and VAV3 as barely methylated in normal cells and highly methylated in cancer cells.
Osteogenic differentiation and gene expression profile of human dental follicle cells induced by human dental pulp cells.
Park et al., Seoul, South Korea. In J Mol Histol, Feb 2015
Microarray analysis and quantitative real-time PCR showed that osteogenesis-related genes including WNT2, VCAN, OSR2, FOSB, and POSTN in hDFCs were significantly upregulated after induction by hDPCs-CM compared to hDFCs in normal medium.
The specific role of FAM20C in dentinogenesis.
Qin et al., Dallas, United States. In J Dent Res, Feb 2015
To determine if the dentin defects in the Sox2-Cre;Fam20C(fl/fl) mice were associated with the enamel defects and hypophosphatemia, we crossed Fam20C(fl/fl) mice with Wnt1-Cre and Osr2-Cre transgenic mice to inactivate Fam20C in the craniofacial mesenchymal cells that form dentin and alveolar bone.
Pax8 and Pax2 are specifically required at different steps of Xenopus pronephros development.
Umbhauer et al., Paris, France. In Dev Biol, Feb 2015
We further show that Pax8 controls hnf1b, but not lhx1 and Osr2, expression in the kidney field as soon as the mid-neurula stage.
Altered FGF Signaling Pathways Impair Cell Proliferation and Elevation of Palate Shelves.
Liu et al., Shanghai, China. In Plos One, 2014
Besides the altered Fgf7, Fgf10, Dlx5 and Shh expression pattern, the reduced Osr2 expression domain in the lateral mesenchyme also suggests an impaired mediolateral patterning of posterior palate.
Molecular patterning of the mammalian dentition.
Jiang et al., Cincinnati, United States. In Semin Cell Dev Biol, 2014
Bmp4 and Msx1 act in a positive feedback loop to drive sequential tooth formation whereas the Osr2 transcription factor restricts Msx1-mediated expansion of the mesenchymal odontogenic field along both the buccolingual and anteroposterior axes to pattern mouse molar teeth in a single row.
The Arabidopsis ORGAN SIZE RELATED 2 is involved in regulation of cell expansion during organ growth.
Hu et al., In Bmc Plant Biol, 2013
RESULTS: This study characterized a new Arabidopsis ORGAN SIZE RELATED (OSR) gene, OSR2, which participates in the regulation of cell expansion process during organ growth.
The odd-skipped related genes Osr1 and Osr2 are induced by 1,25-dihydroxyvitamin D3.
Verstuyf et al., Leuven, Belgium. In J Steroid Biochem Mol Biol, 2013
The odd-skipped related genes Osr1 and Osr2 encode closely related zinc finger containing transcription factors that are expressed in developing limb.
Negative regulation of Odd-skipped related 2 by TGF-beta achieves the induction of cellular migration and the arrest of cell cycle.
Amano et al., Suita, Japan. In Biochem Biophys Res Commun, 2012
These results suggest that Osr2 is involved in TGF-beta regulating cell migration and cell cycle via a Smad3-ATF2 transcriptional complex mediating pathway.
The Osr1 and Osr2 genes act in the pronephric anlage downstream of retinoic acid signaling and upstream of Wnt2b to maintain pectoral fin development.
Gómez-Skarmeta et al., Sevilla, Spain. In Development, 2012
The Osr1 and Osr2 genes act in the pronephric anlage downstream of retinoic acid signaling and upstream of Wnt2b to maintain pectoral fin development.
Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field.
Jiang et al., Rochester, United States. In Dev Biol, 2011
Mice lacking both Osr2 and Pax9 exhibited early tooth developmental arrest with significantly reduced Bmp4 and Msx1 mRNA expression in the developing tooth mesenchyme.
The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation.
Jiang et al., Rochester, United States. In Dev Biol, 2011
These data indicate that Osr1 and Osr2 function redundantly to control synovial joint formation.
Odd-skipped related 2 regulates genes related to proliferation and development.
Amano et al., Suita, Japan. In Biochem Biophys Res Commun, 2010
Osr2 plays important roles in cell proliferation and development.
Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into a single row.
Jiang et al., Rochester, United States. In Science, 2009
study found mice lacking Osr2 develop supernumerary teeth lingual to their molars because of expansion of the odontogenic field; Osr2 was expressed in a lingual-to-buccal gradient and restricted expression of bone morphogenetic protein 4
Controlling the number of tooth rows.
Mikkola, Helsinki, Finland. In Sci Signal, 2008
Mouse genetics has revealed a pivotal role for the transcription factor Osr2 in this process.
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