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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Oncostatin M receptor

OSMR, oncostatin M receptor
This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009] (from NCBI)
Top mentioned proteins: oncostatin M, Interleukin-6, NMDA receptor, STAT3, IL-31
Papers on OSMR
RET mutation p.S891A in a Chinese family with familial medullary thyroid carcinoma and associated cutaneous amyloidosis binding OSMR variant p.G513D.
New
Ma et al., Hangzhou, China. In Oncotarget, Nov 2015
There are no reports on the relationship between familial medullary thyroid carcinoma (FMTC) associated with cutaneous amyloidosis (CA) and RET or OSMR/IL31RA gene mutations.
Prerequisites for Functional Interleukin 31 Signaling and Its Feedback Regulation by Suppressor of Cytokine Signaling 3 (SOCS3).
New
Horejs-Hoeck et al., Salzburg, Austria. In J Biol Chem, Nov 2015
IL-31-induced signaling is mediated by a receptor complex composed of oncostatin M receptor β and the cytokine-specific receptor subunit IL-31Rα, of which there are several isoforms.
Oncostatin M protects against demyelination by inducing a protective microglial phenotype.
New
Hellings et al., Diepenbeek, Belgium. In Glia, Oct 2015
In this study, we reveal that the OSM receptor (OSMR) was robustly upregulated on microglia/macrophages and astrocytes in the cuprizone-induced demyelination model.
Transcriptomic analyses of genes differentially expressed by high-risk and low-risk human papilloma virus E6 oncoproteins.
New
Ganguly et al., Bhubaneshwar, India. In Virusdisease, Sep 2015
The microarray results were confirmed by quantitative real-time PCR for some representative genes like IFI27, CTNNA1, OSMR, CYP1B1, TNFSF13, LAMA2 and COL5A3.
Th2 Cytokines Augment IL-31/IL-31RA Interactions via STAT6-dependent IL-31RA Expression.
New
Madala et al., Seattle, United States. In J Biol Chem, Jun 2015
Interleukin 31 receptor α (IL-31RA) is a novel Type I cytokine receptor that pairs with oncostatin M receptor to mediate IL-31 signaling.
Oncostatin-M differentially regulates mesenchymal and proneural signature genes in gliomas via STAT3 signaling.
New
Shastry et al., Pune, India. In Neoplasia, Feb 2015
Analysis of TCGA and REMBRANDT data revealed that expression of OSMR but not IL-6R or LIFR is upregulated in GBM and has negative correlation with survival.
A genome-wide association study for clinical mastitis in first parity US Holstein cows using single-step approach and genomic matrix re-weighting procedure.
Maltecca et al., Raleigh, United States. In Plos One, 2014
Other genes annotated on chromosome 20 are involved in mammary gland metabolism (GHR, OXCT1), antibody production and phagocytosis of bacterial cells (C6, C7, C9, C1QTNF3), tumor suppression (DAB2), involution of mammary epithelium (OSMR) and cytokine regulation (PRLR).
Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects.
Li et al., San Francisco, United States. In Int J Mol Sci, 2014
As a result, mechanisms for increasing (AhR, histamine H1 receptor, histone deacetylase or HDAC, hsp90, nuclear factor kappa B or NFκB, MEK, oncostatin M receptor, Jak kinase, and p38 MAPK) and decreasing (vacuolar ATPase or V-ATPase) and mTOR) TF expression levels were uncovered.
Oncostatin M receptor is a novel therapeutic target in cervical squamous cell carcinoma.
Review
Coleman et al., Cambridge, United Kingdom. In J Pathol, 2014
An exciting new molecular target for the treatment of cervical squamous cell carcinoma (SCC), and possibly for SCCs at other anatomical sites, is the oncostatin M receptor (OSMR).
Signaling by IL-31 and functional consequences.
Review
Lüscher et al., Aachen, Germany. In Eur J Cell Biol, 2012
IL-31 signals through a heterodimeric receptor composed of OSMR and IL-31RA, a complex that stimulates the JAK-STAT, the RAS/ERK and the PI3K/AKT signal transduction pathways.
Increased serum human β-defensin-2 levels in atopic dermatitis: relationship to IL-22 and oncostatin M.
GeneRIF
Watanabe et al., Tokyo, Japan. In Immunobiology, 2012
enhanced production by beta-defensin-2 in T cells
Sustained RANKL response to parathyroid hormone in oncostatin M receptor-deficient osteoblasts converts anabolic treatment to a catabolic effect in vivo.
GeneRIF
Sims et al., Melbourne, Australia. In J Bone Miner Res, 2012
These data indicate that the transient RANKL induction by intermittent PTH administration, which is associated with its anabolic action, is changed to a prolonged induction in OSMR-deficient osteoblasts, resulting in bone destruction.
A new c.1845A→T of oncostatin M receptor-β mutation and slightly enhanced oncostatin M receptor-β expression in a Chinese family with primary localized cutaneous amyloidosis.
GeneRIF
Chen et al., Beijing, China. In Eur J Dermatol, 2012
This study identified a new heterozygous OSMR missense mutation in primary localized cutaneous amyloidosis.
Overexpression of the oncostatin M receptor in cervical squamous cell carcinoma cells is associated with a pro-angiogenic phenotype and increased cell motility and invasiveness.
GeneRIF
Coleman et al., Cambridge, United Kingdom. In J Pathol, 2011
We conclude that OSMR overexpression in cervical SCC cells provides increased sensitivity to OSM, which induces pro-malignant changes.
Methylation of OSMR gene is frequently observed in non-invasive colorectal cancer.
GeneRIF
Sanada et al., Yokohama, Japan. In Anticancer Res, 2011
Aberrant methylation of the OSMR gene is associated with non-invasive colorectal cancer.
New insight into mechanisms of pruritus from molecular studies on familial primary localized cutaneous amyloidosis.
Review
McGrath et al., London, United Kingdom. In Br J Dermatol, 2009
and in 2008 pathogenic heterozygous missense mutations were identified in the OSMR gene, which encodes oncostatin M receptor beta (OSMRbeta), an interleukin (IL)-6 family cytokine receptor.
Jaks and cytokine receptors--an intimate relationship.
Review
Behrmann et al., Luxembourg, Luxembourg. In Biochem Pharmacol, 2006
Here, we will discuss underlying mechanisms as well as some structural features with a focus on Jak1 and two of the signal transducing receptor subunits of interleukin (IL)-6 type cytokines, gp130 and OSMR.
Oncostatin M in the development of the nervous system.
Review
Morikawa, Wakayama, Japan. In Anat Sci Int, 2005
In the adult central nervous system (CNS), OSM receptor (OSMR) beta was observed in meningeal cells of pia mater, epithelial cells of the choroid plexus and olfactory astrocyte-like glia surrounding the glomeruli of the olfactory bulb.
Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice.
Impact
Gross et al., Seattle, United States. In Nat Immunol, 2004
IL-31 signals through a receptor composed of IL-31 receptor A and oncostatin M receptor.
The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor.
Impact
Mosley et al., Seattle, United States. In Science, 1992
Leukemia inhibitory factor (LIF) and interleukin-6 (IL-6) are multifunctional cytokines with many similar activities.
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