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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Osteoclast associated, immunoglobulin-like receptor

Oscar, osteoclast-associated receptor
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on Oscar
The osteoclast-associated receptor (OSCAR) is a novel receptor regulated by oxidized low-density lipoprotein in human endothelial cells.
GeneRIF
Hofbauer et al., Dresden, Germany. In Endocrinology, 2011
OSCAR is expressed in vascular endothelial cells and is regulated by oxLDL involving NFATc1
OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice.
GeneRIF
Trowsdale et al., Cambridge, United Kingdom. In J Clin Invest, 2011
Data suggest that OSCAR is a collagen receptor that binds to specific collagen motifs and costimulates osteoclastogenesis in DAP12-deficient humans and mice.
The role of osteoclast-associated receptor in osteoimmunology.
GeneRIF
Goettsch et al., Marburg an der Lahn, Germany. In J Immunol, 2011
This review discusses the structure-function relationship, expression pattern, and physiological role of OSCAR in osteoimmunology and summarizes its potential implications for human diseases.
Upstream stimulatory factors regulate OSCAR gene expression in RANKL-mediated osteoclast differentiation.
GeneRIF
Kim et al., Kwangju, South Korea. In J Mol Biol, 2008
Results indicate that USFs 1 and 2 serve as modulators in the induction of OSCAR and RANKL-mediated osteoclastogenesis.
Induction of osteoclast-associated receptor, a key osteoclast costimulation molecule, in rheumatoid arthritis.
GeneRIF
Schett et al., Erlangen, Germany. In Arthritis Rheum, 2008
OSCAR (osteoclast associated immunoglobulin-like receptor)is expressed by erosion front osteoclasts and by synovial microvessels mononuclear cells. OSCAR is induced in monocytes of rheumatod arthritis patients, facilitating osteoclast differentiation
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