Gap junctions are essential for murine primordial follicle assembly immediately before birth.
Beijing, China. In Reproduction, Feb 2016
In addition, the expression of ovarian somatic cell (OSC)-specific genes, such as Notch2, Foxl2 and Irx3, was negatively affected by GJC blockers, whereas oocyte-related genes, such as Ybx2, Nobox and Sohlh1, were hardly affected, implying that the establishment of GJC during this period may be more important to OSCs than to oocytes.
Arylpiperidines as a new class of oxidosqualene cyclase inhibitors.
München, Germany. In Eur J Med Chem, Jan 2016
UNASSIGNED: The cyclization of oxidosqualene to lanosterol, catalyzed by the enzyme oxidosqualene cyclase (OSC), goes through a number of carbocationic high energy intermediates (HEI), and mimicking these intermediates is a promising approach for the development of OSC inhibitors.
Role of H2S Donors in Cancer Biology.
Singapore, Singapore. In Handb Exp Pharmacol, 2014
Hydrogen sulfide (H2S) donors including organosulfur compounds (OSC), inorganic sulfide salts, and synthetic compounds are useful tools in studies to elucidate the effects of H2S in cancer biology.
Potential role of nonstatin cholesterol lowering agents.
Roma, Italy. In Iubmb Life, 2011
In particular, due to their unique position downstream from HMGR, the inhibition of squalene synthase, farnesyl diphosphate farnesyltransferase (FDFT1), squalene epoxidase (SQLE), and oxidosqualene cyclase:lanosterol synthase (OSC) should decrease plasma levels of cholesterol without affecting ubiquinone, dolichol, and isoprenoid metabolism.
Inhibition of squalene synthase upregulates PCSK9 expression in rat liver.
Tampa, United States. In Arch Biochem Biophys, 2008
These observations suggest an involvement of PCSK9 in hepatic LDL receptor protein degradation and perhaps, in increasing the rate of LDL receptor cycling resulting in lower serum cholesterol levels in response to cholesterol biosynthesis inhibitors.
Molecular genetics of plant sterol backbone synthesis.
Yokohama, Japan. In Lipids, 2007
Since three enzymes, 3-hydroxy-3-methylglutaryl CoA reductase, farnesyl diphosphate synthase, and lanosterol synthase, have been functionally characterized in planta, we reviewed recent progress on these enzymes.