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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Estrogen-related receptor beta

orphan nuclear receptor, ERRbeta
This gene encodes a protein with similarity to the estrogen receptor. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, V1a, hormone-receptor, Nurr1
Papers on orphan nuclear receptor
The Orphan Nuclear Receptor TLX/NR2E1 in Neural Stem Cells and Diseases.
New
Xiong et al., Chongqing, China. In Neurosci Bull, Feb 2016
UNASSIGNED: The human TLX gene encodes an orphan nuclear receptor predominantly expressed in the central nervous system.
Germ Cell Nuclear Factor (GCNF) Represses Oct4 Expression and Globally Modulates Gene Expression in Human Embryonic Stem (hES) Cells.
New
Cooney et al., Austin, United States. In J Biol Chem, Feb 2016
Here we show that expression of human Oct4 is directly repressed by germ cell nuclear factor (GCNF), an orphan nuclear receptor, in hES cells.
TLX-Its Emerging Role for Neurogenesis in Health and Disease.
New
Funa et al., Thiruvananthapuram, India. In Mol Neurobiol, Feb 2016
UNASSIGNED: The orphan nuclear receptor TLX, also called NR2E1, is a factor important in the regulation of neural stem cell (NSC) self-renewal, neurogenesis, and maintenance.
CREB/GSK-3β signaling pathway regulates the expression of TR4 orphan nuclear receptor gene.
New
Kim et al., South Korea. In Mol Cell Endocrinol, Feb 2016
UNASSIGNED: In this study, we show that reduction of glucose concentration increases TR4 expression in 3T3-L1 cells via stimulation of the GSK-3β-CREB pathway.
Paeoniflorin inhibits imiquimod-induced psoriasis in mice by regulating Th17 cell response and cytokine secretion.
New
Li et al., Beijing, China. In Eur J Pharmacol, Jan 2016
Mouse spleen cells were incubated under Th17 polarizing conditions, then with PF (2, 20, and 200μg/ml) and cell viability, Th17 differentiation, and Th17 cytokines and the orphan nuclear receptor (RORγt) mRNA levels were assessed.
Choose your destiny: Make a cell fate decision with COUP-TFII.
Review
New
Tsai et al., Houston, United States. In J Steroid Biochem Mol Biol, Jan 2016
Emerging evidence demonstrates that the orphan nuclear receptor COUP-TFII serves as a key regulator in determining the cell identity during embryonic development.
The New Molecular Landscape of Cushing's Disease.
Review
New
Allolio et al., Würzburg, Germany. In Trends Endocrinol Metab, Oct 2015
Its molecular basis has remained poorly understood until the past few years, when several proteins and genes [such as testicular orphan nuclear receptor 4 (TR4) and heat shock protein 90 (HSP90)] were found to play key roles in the disease.
Constitutive activities of estrogen-related receptors: Transcriptional regulation of metabolism by the ERR pathways in health and disease.
Review
New
Xie et al., Duarte, United States. In Biochim Biophys Acta, Sep 2015
The estrogen-related receptors (ERRs) comprise a small group of orphan nuclear receptor transcription factors.
Orphan Nuclear Receptor ERRα Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation.
New
Impact
Jo et al., Taejŏn, South Korea. In Immunity, Aug 2015
The orphan nuclear receptor estrogen-related receptor α (ERRα; NR3B1) is a key metabolic regulator, but its function in regulating inflammation remains largely unknown.
Structures and regulation of non-X orphan nuclear receptors: A retinoid hypothesis.
Review
New
Xu et al., Grand Rapids, United States. In J Steroid Biochem Mol Biol, Aug 2015
Here we review the recent literature on orphan nuclear receptor structural analysis and ligand identification, particularly on the orphan nuclear receptors that do not heterodimerize with retinoid X receptors, which we term as non-X orphan receptors.
Retinoic acid-related orphan receptor RORβ, circadian rhythm abnormalities and tumorigenesis (Review).
Review
New
Zhu et al., Hangzhou, China. In Int J Mol Med, Jun 2015
Nuclear receptors are a superfamily of transcription factors including the steroid hormone receptors, non-steroid hormone receptors and the orphan nuclear receptor family.
Semaphorin 3E suppresses tumor cell death triggered by the plexin D1 dependence receptor in metastatic breast cancers.
Impact
Mann et al., Marseille, France. In Cancer Cell, 2013
We further showed that Plexin D1 triggers apoptosis via interaction with the orphan nuclear receptor NR4A1.
TH17 cell differentiation is regulated by the circadian clock.
Impact
Hooper et al., Dallas, United States. In Science, 2013
Their lineage specification is regulated by the orphan nuclear receptor RORγt.
Liver receptor homolog-1 is essential for pregnancy.
Impact
Murphy et al., Saint-Hyacinthe, Canada. In Nat Med, 2013
One such element, liver receptor homolog-1 (Lrh-1), is an orphan nuclear receptor that regulates metabolism and hormone synthesis.
Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cells.
GeneRIF
Robson et al., Singapore, Singapore. In Stem Cells, 2013
Esrrb forms a heterodimer complex with Sox2 in ES cells to regulate transcriptional differences between mouse embryonic and epiblast stem cells.
Retinoic-acid-receptor-related orphan nuclear receptor alpha is required for natural helper cell development and allergic inflammation.
Impact
Takei et al., Vancouver, Canada. In Immunity, 2012
Natural helper (NH) cells are innate lymphoid cells (ILCs) that produce T helper-2 (Th2)-cell-type cytokines in the lung- and gut-associated lymphoid tissues.
A novel missense mutation in the ESRRB gene causes DFNB35 hearing loss in a Tunisian family.
GeneRIF
Aifa et al., Sfax, Tunisia. In Eur J Med Genet, 2011
A novel missense mutation in the ESRRB gene causes DFNB35 hearing loss in a Tunisian family.
Involvement of estrogen receptor-related receptors in human ovarian endometriosis.
GeneRIF
Loverro et al., Castellana Grotte, Italy. In Fertil Steril, 2011
Data confirm the up-regulation of ER-beta as the principal receptor involved in the progression of human endometriosis.
Parkin degrades estrogen-related receptors to limit the expression of monoamine oxidases.
GeneRIF
Feng et al., Buffalo, United States. In Hum Mol Genet, 2011
Parkin degrades ESRRA, ESRRB and ESRRG to limit the expression of MAOA and MAOB.
The orphan nuclear hormone receptor ERRbeta controls rod photoreceptor survival.
GeneRIF
Blackshaw et al., Baltimore, United States. In Proc Natl Acad Sci U S A, 2010
ERRbeta is a critical regulator of rod photoreceptor function and survival
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