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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

G protein-coupled receptor, family C, group 5, member D

orphan G-protein-coupled receptor, GPRC5D
The protein encoded by this gene is a member of the G protein-coupled receptor family; however, the specific function of this gene has not yet been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, GPCR, CAN, Neuropeptide, V1a
Papers on orphan G-protein-coupled receptor
Novel chiral-diazepines function as specific, selective receptor agonists with variable coupling and species variability in human, mouse and rat BRS-3 receptor cells.
New
Jensen et al., Bethesda, United States. In Peptides, Jan 2016
Bombesin receptor subtype-3 (BRS-3) is an orphan G-protein coupled receptor which is classified in the bombesin receptor (BnR) family with which it shares high homology.
Leukocyte Trafficking to the Small Intestine and Colon.
Review
New
Butcher et al., Stanford, United States. In Gastroenterology, Dec 2015
Recent advances include the discovery of an unexpected role for lectin CD22 as a B-cell homing receptor GALT, and identification of the orphan G-protein-coupled receptor GPR15 as a T-cell chemoattractant/trafficking receptor for the colon.
GPR139, an Orphan Receptor Highly Enriched in the Habenula and Septum, Is Activated by the Essential Amino Acids L-Tryptophan and L-Phenylalanine.
New
Lovenberg et al., San Diego, United States. In Mol Pharmacol, Nov 2015
GPR139 is an orphan G-protein-coupled receptor expressed in the central nervous system.
Loss of glutamic acid decarboxylase (Gad67) in striatal neurons expressing the Drdr1a dopamine receptor prevents L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned mice.
New
Soghomonian et al., Boston, United States. In Neuroscience, Oct 2015
In light of evidence that the dopamine Drd1a receptor is densely expressed in striatal direct pathway striatal neurons while the orphan G-protein-coupled receptor Gpr88 is densely expressed in striatal direct and indirect pathway striatal neurons, we used a cre-lox strategy to produce two lines of mice that were Gad1 (Gad1 is the gene encoding for Gad67)-deficient in neurons expressing the Drd1a or the Gpr88 receptor.
Apelin protect against multiple organ injury following hemorrhagic shock and decrease the inflammatory response.
New
Arafah et al., Riyadh, Saudi Arabia. In Int J Appl Basic Med Res, Sep 2015
Apelin is an endogenous ligand of orphan G-protein coupled receptor APJ.
High-throughput screening of antagonists for the orphan G-protein coupled receptor GPR139.
New
Wang et al., Shanghai, China. In Acta Pharmacol Sin, Jul 2015
AIM: To discover antagonists of the orphan G-protein coupled receptor GPR139 through high-throughput screening of a collection of diverse small molecules.
A review of ELTD1, a pro-angiogenic adhesion GPCR.
Review
Harris et al., Oxford, United Kingdom. In Biochem Soc Trans, 2014
Epidermal growth factor, latrophilin and seven-transmembrane domain-containing 1 (ELTD1), an orphan G-protein-coupled receptor (GPCR) belonging to the adhesion GPCR family, has recently been identified as a potential cancer biomarker and a novel regulator of angiogenesis.
Physiological roles of ghrelin on obesity.
Review
Kojima et al., Kurume, Japan. In Obes Res Clin Pract, 2014
Ghrelin is a stomach hormone that acts as an endogenous ligand of orphan G-protein coupled receptor.
Functional Antagonists of EBI-2
Review
Rickert et al., Bethesda, United States. In Unknown Journal, 2014
An exciting new development in the field is the revelation of a novel chemotactic axis involving the recognition of oxysterol compounds by the orphan G-protein-coupled receptor (GPCR), Epstein-Barr virus-induced gene 2 (EBI2).
The emerging roles of GPRC5A in diseases.
Review
Rigoutsos et al., Philadelphia, United States. In Oncoscience, 2013
The 'Retinoic Acid-Inducible G-protein-coupled receptors' or RAIG are a group comprising the four orphan receptors GPRC5A, GPRC5B, GPRC5C and GPRC5D.
A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis.
Impact
Buffa et al., Oxford, United Kingdom. In Cancer Cell, 2013
This approach identified ELTD1, an orphan G-protein-coupled receptor whose expression is induced by VEGF/bFGF and repressed by DLL4 signaling.
Oxysterols direct B-cell migration through EBI2.
Impact
Lovenberg et al., San Diego, United States. In Nature, 2011
EBI2 (also called GPR183) is an orphan G-protein-coupled receptor that is highly expressed in spleen and upregulated upon Epstein-Barr-virus infection.
EBI2 mediates B cell segregation between the outer and centre follicle.
Impact
Cyster et al., San Francisco, United States. In Nature, 2009
Here we present a role for the orphan G-protein-coupled receptor, Epstein-Barr virus induced molecule-2 (EBI2, also known as GPR183), in this process.
Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors.
Impact
Ling et al., San Francisco, United States. In Nature, 2004
3), a previously orphan G-protein-coupled receptor (GPCR), functions as a receptor for the citric acid cycle intermediate succinate.
The RAIG family member, GPRC5D, is associated with hard-keratinized structures.
GeneRIF
Shimomura et al., Tsukuba, Japan. In J Invest Dermatol, 2004
GPRC5D is involed in the regulation of keratin synthesis in hard epithelial tissue.
PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect.
Impact
Offermanns et al., Heidelberg, Germany. In Nat Med, 2003
Here, we show that the orphan G-protein-coupled receptor, 'protein upregulated in macrophages by interferon-gamma' (mouse PUMA-G, human HM74), is highly expressed in adipose tissue and is a nicotinic acid receptor.
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