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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Hypoxia up-regulated 1

ORP150, 140-kDa, grp170, 150-kDa oxygen-regulated protein
The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, CD45, HAD, fibrillin-1
Papers on ORP150
Deletion of Atf6α enhances kainate-induced neuronal death in mice.
New
Hori et al., Kanazawa, Japan. In Neurochem Int, Jan 2016
We previously reported that the 150-kDa oxygen-regulated protein (ORP150), a molecular chaperone in the endoplasmic reticulum (ER), inhibited the l-glutamate-induced neuronal death, at least partly, by improving Ca(2+) homeostasis in the ER.
Involvement of Nrf2 in proteasome inhibition-mediated induction of ORP150 in thyroid cancer cells.
New
Wang et al., Shenyang, China. In Oncotarget, Jan 2016
UNASSIGNED: Oxygen-regulated protein 150 (ORP150) is an inducible ER chaperone by numerous cellular insults and sustains cellular viability.
Role of the ER stress in prostaglandin E2/E-prostanoid 2 receptor involved TGF-β1-induced mice mesangial cell injury.
New
Yin et al., Nantong, China. In Mol Cell Biochem, Nov 2015
Immunohistochemical analysis showed significant augment of TRPC4 and ORP150 in the kidney of EP2(-/-) mice compared with WT mice.
A novel nanoparticle containing neuritin peptide with grp170 induces a CTL response to inhibit tumor growth.
New
Yang et al., Fuzhou, China. In J Neurooncol, Oct 2015
In this study, we constructed a novel nanoparticle containing neuritin peptide with grp170.
Enhancement of Bacillus thuringiensis insecticidal activity by combining Cry1Ac and bi-functional toxin HWTX-XI from spider.
New
Xia et al., Changsha, China. In J Invertebr Pathol, Mar 2015
Western blot analysis and microscopic observation revealed that the recombinant strain could express 140-kDa Cry1Ac-HWTX-XI fusion protein and produce parasporal inclusions during sporulation.
Dual roles of palladin protein in in vitro myogenesis: inhibition of early induction but promotion of myotube maturation.
Wang et al., Tainan City, Taiwan. In Plos One, 2014
Additionally, overexpression of 140-kDa palladin inhibits myoblast differentiation while 200-kDa and 90-kDa palladin-overexpressed cells display an enhanced differentiation rate.
Identification of sialylated glycoproteins from metabolically oligosaccharide engineered pancreatic cells.
Zhang et al., Baltimore, United States. In Clin Proteomics, 2014
A comparison of two of these glycoproteins, LAMP1 and ORP150, in histological tumor samples showed overexpression of these proteins in the cancerous tissue demonstrating that our approach constitutes a viable strategy to identify and discover sialoglycoproteins associated with cancer, which can serve as biomarkers for cancer diagnosis or targets for therapy.
Astragaloside IV attenuates proteinuria in streptozotocin-induced diabetic nephropathy via the inhibition of endoplasmic reticulum stress.
Cheng et al., Wuhan, China. In Bmc Nephrol, 2014
The expression of glucose-regulated protein 78 (GRP78) and 150 kDa oxygen-regulated protein (ORP150) mRNA and protein was determined by real-time PCR and western blotting respectively.
The Endoplasmic Reticulum Chaperone GRP170: From Immunobiology to Cancer Therapeutics.
Review
Wang et al., Richmond, United States. In Front Oncol, 2013
Glucose-regulated protein 170 (GRP170) is the largest member of glucose-regulated protein family that resides in the endoplasmic reticulum (ER).
Molecular chaperone ORP150 in ER stress-related diseases.
Review
Cechowska-Pasko et al., Białystok, Poland. In Curr Pharm Des, 2012
The hallmark of the cytoprotective branch of UPR is stimulation of the expression of ER chaperones, of which ORP150 has gained a great deal of attention.
New paradigm for intrinsic function of heat shock proteins as endogenous ligands in inflammation and innate immunity.
Review
Sato et al., Sapporo, Japan. In Curr Mol Med, 2012
More interestingly, recent study demonstrated that innate immune responses elicited by both endogenous and exogenous danger signals were spatially and temporally regulated and this can be manipulated using Hsp90 or oxygen-regulated protein 150 (ORP150), thereby controlling the immune responses.
CD22 and autoimmune disease.
Review
Smith et al., Berlin, Germany. In Int Rev Immunol, 2012
CD22 is a 140-kDa member of the Siglec family of cell surface proteins that is expressed by most mature B-cell lineages.
Molecular chaperoning by glucose-regulated protein 170 in the extracellular milieu promotes macrophage-mediated pathogen sensing and innate immunity.
GeneRIF
Wang et al., Richmond, United States. In Faseb J, 2012
Results reveal a previously unrecognized attribute of Grp170 as a superior DNA-binding chaperone capable of amplifying TLR9 activation on pathogen recognition.
The functional role of stress proteins in ER stress mediated cell death.
Review
Bando, Asahikawa, Japan. In Anat Sci Int, 2012
We have reported the roles of novel stress proteins, namely 150-kDa oxygen-regulated protein, 94-kDa glucose-regulated protein and RA410.
Control of embryonic stem cell lineage commitment by core promoter factor, TAF3.
Impact
GeneRIF
Tjian et al., Berkeley, United States. In Cell, 2011
Study shows that this TAF3 activity is critical for early lineage segregation during stem cell differentiation.
Effects of ORP150 on appearance and function of pancreatic beta cells following acute necrotizing pancreatitis.
GeneRIF
Liu et al., Wuhan, China. In Pathol Res Pract, 2011
Results imply a probable role of ORP150 in the changes in appearance and function of pancreatic beta cells following acute necrotizing pancreatitis, through the pathway of endoplasmic reticulum stress.
Involvement of oxygen-regulated protein 150 in AMP-activated protein kinase-mediated alleviation of lipid-induced endoplasmic reticulum stress.
GeneRIF
Xia et al., Guangzhou, China. In J Biol Chem, 2011
AICAR infusion enhanced ORP150 expression, resulting in the marked amelioration of hepatic ER stress and apoptosis
The timing of perinatal hypoxia/ischemia events in term neonates: a retrospective autopsy study. HSPs, ORP-150 and COX2 are reliable markers to classify acute, perinatal events.
GeneRIF
Fineschi et al., Foggia, Italy. In Diagn Pathol, 2009
Report ORP-150 levels in autopsy tissue after hypoxia/ischemia events in term neonates.
ORP150 protects against hypoxia/ischemia-induced neuronal death.
Impact
Tohyama et al., Ōsaka, Japan. In Nat Med, 2001
Oxygen-regulated protein 150 kD (ORP150) is a novel endoplasmic-reticulum-associated chaperone induced by hypoxia/ischemia.
Expression of metalloproteases by cardiac myocytes and fibroblasts in vitro.
Borg et al., Columbia, United States. In Cardiovasc Pathol, 1997
The reaction of SDS-activated MMP-2 produced a 140-kDa fragment from collagen types I and III.
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