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Oxysterol binding protein-like 10

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: OSBP, ORC2, fibrillin-1, CAN, ORP3
Papers on ORP10
The mutational pattern of primary lymphoma of the central nervous system determined by whole-exome sequencing.
Siebert et al., Kiel, Germany. In Leukemia, Mar 2015
In addition to the well-known targets of aberrant SHM (aSHM) (PIM1), our data suggest new targets of aSHM (KLHL14, OSBPL10, and SUSD2).
Identification of Novel Epigenetic Markers of Prostate Cancer by NotI-Microarray Analysis.
Kashuba et al., Moscow, Russia. In Dis Markers, 2014
Based on these data, we proposed the set of potential biomarkers for detection of prostate cancer and discrimination between prostate tumors with different malignancy and aggressiveness: BHLHE40, FOXP1, LOC285205, ITGA9, CTDSPL, FGF12, LOC440944/SETD5, VHL, CLCN2, OSBPL10/ZNF860, LMCD1, FAM19A4, CAND2, MAP4, KY, and LRRC58.
A genome-wide approach to link genotype to clinical outcome by utilizing next generation sequencing and gene chip data of 6,697 breast cancer patients.
Győrffy et al., Budapest, Hungary. In Genome Med, 2014
RESULTS: According to this approach, the top driver oncogenes having a mutation prevalence over 5 % included AKT1, TRANK1, TRAPPC10, RPGR, COL6A2, RAPGEF4, ATG2B, CNTRL, NAA38, OSBPL10, POTEF, SCLT1, SUN1, VWDE, MTUS2, and PIK3CA, and the top tumor suppressor genes included PHEX, TP53, GGA3, RGS22, PXDNL, ARFGEF1, BRCA2, CHD8, GCC2, and ARMC4.
Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years.
Marazita et al., Pittsburgh, United States. In G3 (bethesda), 2014
Moreover, we nominated novel loci not previously implicated in chronic periodontitis or related pathways, including the regions 3p22 near OSBPL10 (a lipid receptor implicated in hyperlipidemia), 4p15 near HSP90AB2P (a heat shock pseudogene), 11p15 near GVINP1 (a GTPase pseudogene), 14q31 near SEL1L (an intracellular transporter), and 18q12 in FHOD3 (an actin cytoskeleton regulator).
Next-generation linkage and association methods applied to hypertension: a multifaceted approach to the analysis of sequence data.
Vieland et al., Columbus, United States. In Bmc Proc, 2013
Our results show that OSBPL10--a disease susceptibility gene for dyslipidemia--may also influence systolic blood pressure (SBP).
Oxysterol-binding proteins: sterol and phosphoinositide sensors coordinating transport, signaling and metabolism.
Li et al., Helsinki, Finland. In Prog Lipid Res, 2013
The functions assigned for mammalian ORPs include coordination of sterol and sphingolipid metabolism and mitogenic signaling (OSBP), control of ER-late endosome (LE) contacts and LE motility (ORP1L), neutral lipid metabolism (ORP2), cell adhesion (ORP3), cholesterol eggress from LE (ORP5), macrophage lipid homeostasis, migration and high-density lipoprotein metabolism (ORP8), apolipoprotein B-100 secretion (ORP10), and adipogenesis (ORP11).
Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins.
Gavin et al., Heidelberg, Germany. In Nature, 2013
We describe a new subfamily of OSBPs, including human ORP5 and ORP10, that transfer PS and propose new mechanisms of action for a protein family that is involved in several human pathologies such as cancer, dyslipidaemia and metabolic syndrome.
cAMP-stimulated phosphorylation of diaphanous 1 regulates protein stability and interaction with binding partners in adrenocortical cells.
Sewer et al., San Diego, United States. In Mol Biol Cell, 2013
In the present study we use mass spectrometry to identify DIAPH1 binding partners and find that DIAPH1 interacts with several proteins, including RhoA, dynamin-1, kinesin, β-tubulin, β-actin, oxysterol-binding protein (OSBP)-related protein 2 (ORP2), and ORP10.
ORP10, a cholesterol binding protein associated with microtubules, regulates apolipoprotein B-100 secretion.
Olkkonen et al., Helsinki, Finland. In Biochim Biophys Acta, 2012
ORP10/OSBPL10 is a member of the oxysterol-binding protein family, and genetic variation in OSBPL10 is associated with dyslipidemias and peripheral artery disease.
Identification of evidence suggestive of an association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population.
Morishita et al., Suita, Japan. In J Atheroscler Thromb, 2010
Single-nucleotide polymorphisms in OSBPL10 is associated with peripheral arterial disease.
Global comparison of gene expression profiles between intramuscular and subcutaneous adipocytes of neonatal landrace pig using microarray.
Jiang et al., Guangzhou, China. In Meat Sci, 2010
Real-time PCR confirmed that genes related to lipid metabolism, such as LPL, FABP4, FABP5 and OSBPL10, were predominantly expressed in subcutaneous adipocytes, whereas BMP4 and BMP7 were highly expressed in intramuscular adipocytes.
Variation in OSBPL10 is associated with dyslipidemia.
Rakugi et al., Suita, Japan. In Hypertens Res, 2010
Overall, the rs2290532 (D254N) polymorphism in OSBPL10 may predispose individuals to hyper-LDL cholesterolemia.
OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism.
Olkkonen et al., Helsinki, Finland. In J Mol Med (berl), 2009
Analysis of variants in three genes encoding OSBP homologues in families with familial low high-density lipoprotein levels or familial combined hyperlipidemia revealed linkage of OSBPL10 single-nucleotide polymorphisms with high triglyceride trait.
The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket.
Olkkonen et al., Dresden, Germany. In Biochem J, 2007
Furthermore, in experiments with either truncated cDNAs encoding the OSBP-related ligand-binding domains of the ORPs or the full-length proteins, photo-25OH was bound to OSBP, ORP3, ORP4, ORP5, ORP6, ORP7, ORP8, ORP10 and ORP11.
The roles of the human lipid-binding proteins ORP9S and ORP10S in vesicular transport.
McMaster et al., Halifax, Canada. In Biochem Cell Biol, 2005
Purified ORP9S protein bound several phosphoinositides, whereas ORP10 bound specifically to phosphatidylinositol 3-phosphate.
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