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Oxysterol binding protein-like 10

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] (from NCBI)
Papers on ORP10
Identification of evidence suggestive of an association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population.
Morishita et al., Suita, Japan. In J Atheroscler Thromb, 2010
Single-nucleotide polymorphisms in OSBPL10 is associated with peripheral arterial disease.
Variation in OSBPL10 is associated with dyslipidemia.
Rakugi et al., Suita, Japan. In Hypertens Res, 2010
Overall, the rs2290532 (D254N) polymorphism in OSBPL10 may predispose individuals to hyper-LDL cholesterolemia.
OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism.
Olkkonen et al., Helsinki, Finland. In J Mol Med (berl), 2009
Analysis of variants in three genes encoding OSBP homologues in families with familial low high-density lipoprotein levels or familial combined hyperlipidemia revealed linkage of OSBPL10 single-nucleotide polymorphisms with high triglyceride trait.
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