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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 12 Nov 2015.

Orosomucoid 1

Orosomucoid, alpha1-acid glycoprotein
This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD45, ACID, Alpha-1, Serum albumin, HAD
Papers using Orosomucoid antibodies
Comprehensive glyco-proteomic analysis of human alpha1-antitrypsin and its charge isoforms
Sang Qing-Xiang Amy et al., In Journal of Cancer, 2005
... Rabbit polyclonal anti-human alpha-1-acid glycoprotein ab440-2 (MW ~50 kDa) was bought from Abcam.
Papers on Orosomucoid
Human plasma protein N-glycosylation.
Wuhrer et al., Leiden, Netherlands. In Glycoconj J, 10 Dec 2015
Thus, as the assessment of protein glycosylation is becoming a major element in clinical and biopharmaceutical research, this review aims to convey the current state of knowledge on the N-glycosylation of the major plasma glycoproteins alpha-1-acid glycoprotein, alpha-1-antitrypsin, alpha-1B-glycoprotein, alpha-2-HS-glycoprotein, alpha-2-macroglobulin, antithrombin-III, apolipoprotein B-100, apolipoprotein D, apolipoprotein F, beta-2-glycoprotein 1, ceruloplasmin, fibrinogen, immunoglobulin (Ig) A, IgG, IgM, haptoglobin, hemopexin, histidine-rich glycoprotein, kininogen-1, serotransferrin, vitronectin, and zinc-alpha-2-glycoprotein. In addition, the less abundant immunoglobulins D and E are included because of their major relevance in immunology and biopharmaceutical research.
Factors Impacting Unbound Vancomycin Concentrations in Different Patient Populations.
Pauwels et al., Leuven, Belgium. In Antimicrob Agents Chemother, 30 Nov 2015
The variables included in the model were patient age, ward, number of coadministered drugs with high protein binding, kidney function (estimated glomerular filtration rate [determined by Chronic Kidney Disease Epidemiology Collaboration formula]), alpha-1-acid glycoprotein, albumin, total bilirubin, IgA, IgM, urea, and total vancomycin concentrations.
Elevated alpha1-acid glycoprotein in gastric cancer patients inhibits the anticancer effects of paclitaxel, effects restored by co-administration of erythromycin.
Ohta et al., Kanazawa, Japan. In Clin Exp Med, 10 Oct 2015
Increased concentrations of α1-acid glycoprotein (AGP), an important drug-binding protein, have been reported in the plasma and ascites of cancer patients.
Differentially expressed urinary biomarkers in children with idiopathic nephrotic syndrome.
Upadhyay et al., New Delhi, India. In Clin Exp Nephrol, 09 Oct 2015
Validation of biomarkers apolipoprotein A1, alpha 2 macroglobulin, orosomucoid 2, retinol binding protein 4 and leucine-rich alpha 2-glycoprotein 1 was done by enzyme-linked immunosorbent assay.
Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation.
Scheuermann et al., Zürich, Switzerland. In Nat Chem, Mar 2015
Using this approach we report the discovery of a low micromolar binder to alpha-1-acid glycoprotein and the affinity maturation of a ligand to carbonic anhydrase IX, an established marker of renal cell carcinoma.
Plasma Concentrations of Hepcidin in Anemic Zimbabwean Infants.
Tielsch et al., Baltimore, United States. In Plos One, Dec 2014
METHODS: We measured plasma hepcidin, ferritin, soluble transferrin receptor (sTfR), alpha-1-acid glycoprotein and C-reactive protein (CRP) by ELISA on archived plasma from 289 HIV-unexposed anemic or non-anemic Zimbabwean infants at ages 3 mo, 6 mo and 12 mo.
Comparative study of serum proteomes in Legg-Calve-Perthes disease.
Bai et al., Xi'an, China. In Bmc Musculoskelet Disord, Dec 2014
Proteins of interest with large differences in expression, S100-A8, alpha-1-acid glycoprotein 1, haptoglobin and apolipoprotein E, were compared by western blotting.
Use of biomarkers in the management of children with lupus.
Edelbauer et al., Innsbruck, Austria. In Curr Rheumatol Rep, 2013
The most promising biomarkers in juvenile-onset SLE include cell-bound complement activation products, some genomic profiles, and urinary proteins such as neutrophil gelatinase-associated lipocalin, monocyte chemoattractant protein-1, and alpha-1-acid glycoprotein.
Effect of alpha-1-acid glycoprotein binding on pharmacokinetics and pharmacodynamics.
Ung et al., Rockville, United States. In Curr Drug Metab, 2013
Alpha-1-acid glycoprotein (AGP, also known as AAG or orosomucoid) is an important plasma protein involved in the binding and transport of many drugs, especially basic compounds.
The urine proteome as a radiation biodosimeter.
Moulder et al., Kansas City, United States. In Adv Exp Med Biol, 2012
Analysis of acute-phase response proteins and markers of acute kidney injury showed increased urinary levels of cystatin superfamily proteins and alpha-1-acid glycoprotein.
α(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress.
Maruyama et al., Kumamoto, Japan. In J Biol Chem, 2012
alpha(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress.
Structure-activity relationships for the binding of polymyxins with human α-1-acid glycoprotein.
Velkov et al., Australia. In Biochem Pharmacol, 2012
The binding properties of the polymyxin class of antibiotics for human alpha-1-acid glycoprotein (AGP) have been characterized.
Association of elevated α₁-acid glycoprotein (AGP) and the prevalence of anemia in Nicaraguan preschool children.
Halleslevens et al., Atlanta, United States. In Food Nutr Bull, 2012
Analyses of Nicaraguan population surveillance data suggest that preschool children with elevated AGP1 levels have higher prevalence of anemia than children with normal AGP1 levels.
[The investigation of alpha1-antitripsin, orozomukoid and ceruloplasmin in peripheral blood and oral fluid. Paradontitis is one of more risk factors of cardiovascular diseases].
Zubarev et al., In Patol Fiziol Eksp Ter, 2012
change of the maintenance of three acute phase proteins: ceruloplasmin, alpha1-antitripsin and orosomucoid in an oral fluid and blood plasma at paradontitis and myocardial infarction
Characterization of 6-mercaptopurine binding site on human alpha1-acid glycoprotein (orosomucoid) using molecular docking.
Pawełczak et al., Sosnowiec, Poland. In Acta Pol Pharm, 2012
Characterization of 6-mercaptopurine binding site on human alpha1-acid glycoprotein (orosomucoid) using molecular docking.
[Psychotropic medication of elderly patients].
Iseki et al., Tokyo, Japan. In Nihon Rinsho, 2012
Drugs medicated for elderly patients show different pharmacokinetics from young patients, because of change in the makeup of bodies, decrease of albumin, increase of alpha-1-acid glycoprotein, hypofunction of metabolism, and excretion by aging.
Determination of human serum alpha1-acid glycoprotein and albumin binding of various marketed and preclinical kinase inhibitors.
Orfi et al., Budapest, Hungary. In Curr Med Chem, 2008
There are about 380 protein kinase inhibitors in drug development as of today and 15 drugs have been marketed already for the treatment of cancer.
Explaining interindividual variability of docetaxel pharmacokinetics and pharmacodynamics in Asians through phenotyping and genotyping strategies.
Lee et al., Singapore, Singapore. In J Clin Oncol, 2002
In multiple linear regression analyses, midazolam clearance and performance status were the only significant covariates of docetaxel clearance, and the area under the curve of docetaxel, serum levels of alpha-1-acid glycoprotein, and ALT were significant predictors of nadir neutrophil count.
Correlation between docetaxel clearance and estimated cytochrome P450 activity by urinary metabolite of exogenous cortisol.
Saijo et al., Tokyo, Japan. In J Clin Oncol, 2000
In multivariate analysis, T6beta-OHF (P <.001), alpha-1-acid glycoprotein (P <.004), AST (P =.007), and age (P =. 022) significantly correlated with docetaxel CL.
Evaluation of three biochemical markers for serially monitoring the therapy of small-cell lung cancer.
Elashoff et al., In J Clin Oncol, 1987
This report reviews the experience at a single institution using three biochemical markers, alpha-1-acid glycoprotein (AGP), carcinoembryonic antigen (CEA), and lactate dehydrogenase (LDH), for serially monitoring the therapy of patients with SCLC.
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