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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 01 Mar 2015.

Orosomucoid 1

Orosomucoid, alpha1-acid glycoprotein
This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CD45, Alpha-1, Serum albumin, HAD
Papers using Orosomucoid antibodies
Comprehensive glyco-proteomic analysis of human alpha1-antitrypsin and its charge isoforms
Supplier
Sang Qing-Xiang Amy et al., In Journal of Cancer, 2005
... Rabbit polyclonal anti-human alpha-1-acid glycoprotein ab440-2 (MW ~50 kDa) was bought from Abcam.
Papers on Orosomucoid
Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation.
New
Impact
Scheuermann et al., Zürich, Switzerland. In Nat Chem, 31 Mar 2015
Using this approach we report the discovery of a low micromolar binder to alpha-1-acid glycoprotein and the affinity maturation of a ligand to carbonic anhydrase IX, an established marker of renal cell carcinoma.
Orosomucoid, an acute response protein with multiple modulating activities.
New
Su et al., Shanghai, China. In J Physiol Biochem, 25 Mar 2015
UNASSIGNED: Orosomucoid (ORM), or alpha-1-acid glycoprotein (AGP), is one of the acute-phase proteins.
Orosomucoid 1 drives opportunistic infections through the polarization of monocytes to the M2b phenotype.
New
Suzuki et al., Galveston, United States. In Cytokine, 14 Mar 2015
UNASSIGNED: Orosomucoid (ORM, composed of two isoforms, ORM1 and ORM2) has been described as an inducer of M2 macrophages, which are cells that decrease host antibacterial innate immunities.
Vitamin B12 supplementation during pregnancy and postpartum improves B12 status of both mothers and infants but vaccine response in mothers only: a randomized clinical trial in Bangladesh.
New
Raqib et al., Dhaka, Bangladesh. In Eur J Nutr, 04 Mar 2015
Blood from mothers (baseline, 72-h post-delivery, 3-month postpartum), newborns and infants (3-month) was analyzed for hemoglobin, B12, methylmalonic acid (MMA), total homocysteine (tHcy), ferritin and serum transferrin receptor, C-reactive protein (CRP) and alpha-1-acid glycoprotein (AGP).
Energy Transfer Studies between Trp Residues of Three Lipocalin Proteins Family, α1-Acid Glycoprotein, (Orosomucoid), β-Lactoglobulin and Porcine Odorant Binding Protein and the Fluorescent Probe, 1-Aminoanthracene (1-AMA).
New
Kmiecik et al., Villeneuve-d'Ascq, France. In J Fluoresc, Jan 2015
Energy transfer studies between Trp residues of α1-acid glycoprotein, β-lactoglobulin and porcine odorant binding protein (OBP) and the fluorescent probe 1-aminoanthracene (1-AMA) were performed.
Study on the Usefulness of APR Scores from the Viewpoint of Proinflammatory Cytokines.
New
Goto et al., Tokorozawa, Japan. In Dis Markers, Dec 2014
We evaluated the usefulness of acute phase reactants (APR) in 46 newborns whose serum up to age 7 days had been stored, with comparison of three types (Group I: infection 15, Group F: fetal inflammatory response syndrome 17, and Group C: control 14) of APR-based scores, those of C-reactive protein (CRP), alpha1-acid glycoprotein (AGP), and haptoglobin (Hp), with proinflammatory cytokine levels.
Proteomic investigation of the severe preeclampsia treatment by low molecular weight heparin.
Zhong et al., In Clin Exp Obstet Gynecol, 2013
To confirm the proteomic data, two meaningful proteins of the six proteins, alpha-1-acid glycoprotein (AGP) and serotransferrin are subjected to immunoblotting.
Use of biomarkers in the management of children with lupus.
Review
Edelbauer et al., Innsbruck, Austria. In Curr Rheumatol Rep, 2013
The most promising biomarkers in juvenile-onset SLE include cell-bound complement activation products, some genomic profiles, and urinary proteins such as neutrophil gelatinase-associated lipocalin, monocyte chemoattractant protein-1, and alpha-1-acid glycoprotein.
Effect of alpha-1-acid glycoprotein binding on pharmacokinetics and pharmacodynamics.
Review
Ung et al., Rockville, United States. In Curr Drug Metab, 2013
Alpha-1-acid glycoprotein (AGP, also known as AAG or orosomucoid) is an important plasma protein involved in the binding and transport of many drugs, especially basic compounds.
The urine proteome as a radiation biodosimeter.
Review
Moulder et al., Kansas City, United States. In Adv Exp Med Biol, 2012
Analysis of acute-phase response proteins and markers of acute kidney injury showed increased urinary levels of cystatin superfamily proteins and alpha-1-acid glycoprotein.
α(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress.
GeneRIF
Maruyama et al., Kumamoto, Japan. In J Biol Chem, 2012
alpha(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress.
Structure-activity relationships for the binding of polymyxins with human α-1-acid glycoprotein.
GeneRIF
Velkov et al., Australia. In Biochem Pharmacol, 2012
The binding properties of the polymyxin class of antibiotics for human alpha-1-acid glycoprotein (AGP) have been characterized.
Association of elevated α₁-acid glycoprotein (AGP) and the prevalence of anemia in Nicaraguan preschool children.
GeneRIF
Halleslevens et al., Atlanta, United States. In Food Nutr Bull, 2012
Analyses of Nicaraguan population surveillance data suggest that preschool children with elevated AGP1 levels have higher prevalence of anemia than children with normal AGP1 levels.
[The investigation of alpha1-antitripsin, orozomukoid and ceruloplasmin in peripheral blood and oral fluid. Paradontitis is one of more risk factors of cardiovascular diseases].
GeneRIF
Zubarev et al., In Patol Fiziol Eksp Ter, 2012
change of the maintenance of three acute phase proteins: ceruloplasmin, alpha1-antitripsin and orosomucoid in an oral fluid and blood plasma at paradontitis and myocardial infarction
Characterization of 6-mercaptopurine binding site on human alpha1-acid glycoprotein (orosomucoid) using molecular docking.
GeneRIF
Pawełczak et al., Sosnowiec, Poland. In Acta Pol Pharm, 2012
Characterization of 6-mercaptopurine binding site on human alpha1-acid glycoprotein (orosomucoid) using molecular docking.
[Psychotropic medication of elderly patients].
Review
Iseki et al., Tokyo, Japan. In Nihon Rinsho, 2012
Drugs medicated for elderly patients show different pharmacokinetics from young patients, because of change in the makeup of bodies, decrease of albumin, increase of alpha-1-acid glycoprotein, hypofunction of metabolism, and excretion by aging.
Determination of human serum alpha1-acid glycoprotein and albumin binding of various marketed and preclinical kinase inhibitors.
Review
Orfi et al., Budapest, Hungary. In Curr Med Chem, 2008
There are about 380 protein kinase inhibitors in drug development as of today and 15 drugs have been marketed already for the treatment of cancer.
Explaining interindividual variability of docetaxel pharmacokinetics and pharmacodynamics in Asians through phenotyping and genotyping strategies.
Impact
Lee et al., Singapore, Singapore. In J Clin Oncol, 2002
In multiple linear regression analyses, midazolam clearance and performance status were the only significant covariates of docetaxel clearance, and the area under the curve of docetaxel, serum levels of alpha-1-acid glycoprotein, and ALT were significant predictors of nadir neutrophil count.
Correlation between docetaxel clearance and estimated cytochrome P450 activity by urinary metabolite of exogenous cortisol.
Impact
Saijo et al., Tokyo, Japan. In J Clin Oncol, 2000
In multivariate analysis, T6beta-OHF (P <.001), alpha-1-acid glycoprotein (P <.004), AST (P =.007), and age (P =. 022) significantly correlated with docetaxel CL.
Evaluation of three biochemical markers for serially monitoring the therapy of small-cell lung cancer.
Impact
Elashoff et al., In J Clin Oncol, 1987
This report reviews the experience at a single institution using three biochemical markers, alpha-1-acid glycoprotein (AGP), carcinoembryonic antigen (CEA), and lactate dehydrogenase (LDH), for serially monitoring the therapy of patients with SCLC.
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