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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

Orosomucoid 1

Orosomucoid, alpha1-acid glycoprotein
This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD45, ACID, Alpha-1, Serum albumin, HAD
Papers using Orosomucoid antibodies
Comprehensive glyco-proteomic analysis of human alpha1-antitrypsin and its charge isoforms
Supplier
Sang Qing-Xiang Amy et al., In Journal of Cancer, 2005
... Rabbit polyclonal anti-human alpha-1-acid glycoprotein ab440-2 (MW ~50 kDa) was bought from Abcam.
Papers on Orosomucoid
Quantitation of the enantiomers of tramadol and its three main metabolites in human whole blood using LC-MS/MS.
New
Josefsson et al., Linköping, Sweden. In J Pharm Biomed Anal, 05 Mar 2016
Chromatography was performed on a chiral alpha-1-acid glycoprotein (AGP) column preceded by an AGP guard column.
Airway reactivity and sphingolipids-implications for childhood asthma.
New
Worgall et al., New York City, United States. In Mol Cell Pediatr, 31 Dec 2015
Orosomucoid-like 3 gene (ORMDL3) and the asthma susceptibility locus 17q21 have been strongly and reproducibly linked to childhood asthma, but how this gene is functionally linked to asthma is incompletely understood.
Fatigue-induced Orosomucoid 1 Acts on C-C Chemokine Receptor Type 5 to Enhance Muscle Endurance.
New
Liu et al., Shanghai, China. In Sci Rep, 31 Dec 2015
In attempting to explore how the body responds to and regulates fatigue, we found in rodent fatigue models that orosomucoid 1 (ORM1) was significantly increased in multiple tissues, including blood and muscle.
Entrapment of alpha1-acid glycoprotein in high-performance affinity columns for drug-protein binding studies.
New
Hage et al., Lincoln, United States. In J Chromatogr B Analyt Technol Biomed Life Sci, 25 Dec 2015
UNASSIGNED: A slurry-based method was developed for the entrapment of alpha1-acid glycoprotein (AGP) for use in high-performance affinity chromatography to study drug interactions with this serum protein.
Human plasma protein N-glycosylation.
New
Wuhrer et al., Leiden, Netherlands. In Glycoconj J, 10 Dec 2015
Thus, as the assessment of protein glycosylation is becoming a major element in clinical and biopharmaceutical research, this review aims to convey the current state of knowledge on the N-glycosylation of the major plasma glycoproteins alpha-1-acid glycoprotein, alpha-1-antitrypsin, alpha-1B-glycoprotein, alpha-2-HS-glycoprotein, alpha-2-macroglobulin, antithrombin-III, apolipoprotein B-100, apolipoprotein D, apolipoprotein F, beta-2-glycoprotein 1, ceruloplasmin, fibrinogen, immunoglobulin (Ig) A, IgG, IgM, haptoglobin, hemopexin, histidine-rich glycoprotein, kininogen-1, serotransferrin, vitronectin, and zinc-alpha-2-glycoprotein. In addition, the less abundant immunoglobulins D and E are included because of their major relevance in immunology and biopharmaceutical research.
Factors impacting unbound vancomycin concentrations in different patient populations.
New
Pauwels et al., Leuven, Belgium. In Antimicrob Agents Chemother, Nov 2015
The variables included in the model were patient age, ward, number of coadministered drugs with high protein binding, kidney function (estimated glomerular filtration rate [determined by Chronic Kidney Disease Epidemiology Collaboration formula]), alpha-1-acid glycoprotein, albumin, total bilirubin, IgA, IgM, urea, and total vancomycin concentrations.
Elevated alpha1-acid glycoprotein in gastric cancer patients inhibits the anticancer effects of paclitaxel, effects restored by co-administration of erythromycin.
New
Ohta et al., Kanazawa, Japan. In Clin Exp Med, Oct 2015
Increased concentrations of α1-acid glycoprotein (AGP), an important drug-binding protein, have been reported in the plasma and ascites of cancer patients.
Differentially expressed urinary biomarkers in children with idiopathic nephrotic syndrome.
New
Upadhyay et al., New Delhi, India. In Clin Exp Nephrol, Oct 2015
Validation of biomarkers apolipoprotein A1, alpha 2 macroglobulin, orosomucoid 2, retinol binding protein 4 and leucine-rich alpha 2-glycoprotein 1 was done by enzyme-linked immunosorbent assay.
Performance of Alpha Fetoprotein in Combination with Alpha-1-acid Glycoprotein for Diagnosis of Hepatocellular Carcinoma Among Liver Cirrhosis Patients.
New
Sanityoso et al., Jakarta, Indonesia. In Acta Med Indones, Jul 2015
AIM: to evaluate the use of alpha-1-acid glycoprotein (AAG) for diagnosing hepatocellular carcinoma (HCC), and to combine with alpha fetoprotein (AFP) as part of routine examination in liver cirrhosis patients.
Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation.
New
Impact
Scheuermann et al., Zürich, Switzerland. In Nat Chem, Mar 2015
Using this approach we report the discovery of a low micromolar binder to alpha-1-acid glycoprotein and the affinity maturation of a ligand to carbonic anhydrase IX, an established marker of renal cell carcinoma.
Plasma Concentrations of Hepcidin in Anemic Zimbabwean Infants.
Tielsch et al., Baltimore, United States. In Plos One, 2014
METHODS: We measured plasma hepcidin, ferritin, soluble transferrin receptor (sTfR), alpha-1-acid glycoprotein and C-reactive protein (CRP) by ELISA on archived plasma from 289 HIV-unexposed anemic or non-anemic Zimbabwean infants at ages 3 mo, 6 mo and 12 mo.
Comparative study of serum proteomes in Legg-Calve-Perthes disease.
Bai et al., Xi'an, China. In Bmc Musculoskelet Disord, 2014
Proteins of interest with large differences in expression, S100-A8, alpha-1-acid glycoprotein 1, haptoglobin and apolipoprotein E, were compared by western blotting.
α(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress.
GeneRIF
Maruyama et al., Kumamoto, Japan. In J Biol Chem, 2012
alpha(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress.
Structure-activity relationships for the binding of polymyxins with human α-1-acid glycoprotein.
GeneRIF
Velkov et al., Australia. In Biochem Pharmacol, 2012
The binding properties of the polymyxin class of antibiotics for human alpha-1-acid glycoprotein (AGP) have been characterized.
Association of elevated α₁-acid glycoprotein (AGP) and the prevalence of anemia in Nicaraguan preschool children.
GeneRIF
Halleslevens et al., Atlanta, United States. In Food Nutr Bull, 2012
Analyses of Nicaraguan population surveillance data suggest that preschool children with elevated AGP1 levels have higher prevalence of anemia than children with normal AGP1 levels.
[The investigation of alpha1-antitripsin, orozomukoid and ceruloplasmin in peripheral blood and oral fluid. Paradontitis is one of more risk factors of cardiovascular diseases].
GeneRIF
Zubarev et al., In Patol Fiziol Eksp Ter, 2012
change of the maintenance of three acute phase proteins: ceruloplasmin, alpha1-antitripsin and orosomucoid in an oral fluid and blood plasma at paradontitis and myocardial infarction
Characterization of 6-mercaptopurine binding site on human alpha1-acid glycoprotein (orosomucoid) using molecular docking.
GeneRIF
Pawełczak et al., Sosnowiec, Poland. In Acta Pol Pharm, 2012
Characterization of 6-mercaptopurine binding site on human alpha1-acid glycoprotein (orosomucoid) using molecular docking.
Explaining interindividual variability of docetaxel pharmacokinetics and pharmacodynamics in Asians through phenotyping and genotyping strategies.
Impact
Lee et al., Singapore, Singapore. In J Clin Oncol, 2002
In multiple linear regression analyses, midazolam clearance and performance status were the only significant covariates of docetaxel clearance, and the area under the curve of docetaxel, serum levels of alpha-1-acid glycoprotein, and ALT were significant predictors of nadir neutrophil count.
Correlation between docetaxel clearance and estimated cytochrome P450 activity by urinary metabolite of exogenous cortisol.
Impact
Saijo et al., Tokyo, Japan. In J Clin Oncol, 2000
In multivariate analysis, T6beta-OHF (P <.001), alpha-1-acid glycoprotein (P <.004), AST (P =.007), and age (P =. 022) significantly correlated with docetaxel CL.
Evaluation of three biochemical markers for serially monitoring the therapy of small-cell lung cancer.
Impact
Elashoff et al., In J Clin Oncol, 1987
This report reviews the experience at a single institution using three biochemical markers, alpha-1-acid glycoprotein (AGP), carcinoembryonic antigen (CEA), and lactate dehydrogenase (LDH), for serially monitoring the therapy of patients with SCLC.
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