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Ornithine decarboxylase 1

ornithine decarboxylase, ODC
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, Antizyme, V1a, HAD
Papers using ornithine decarboxylase antibodies
Molecular Pathology of age-related macular degeneration
Sun Bing et al., In Journal of Biomedical Science, 2008
... PCR amplification of ODC and ODC-AS from cDNAs of murine multiple-tissue panel (Clontech) with primers as shown ...
Analytical Ultracentrifugation in Biochemistry and Polymer Science.
Tyagi Anil Kumar, In PLoS ONE, 1991
... Human wild-type ODC, AZ and AZI and a series of truncated AZ proteins were sub-cloned in the pQE30 vector (Qiagen) with an N-terminal His6-Tag ...
Papers on ornithine decarboxylase
The potential role of polyamines in gill epithelial remodeling during extreme hypoosmotic challenges in the gulf killifish, Fundulus grandis.
Galvez et al., Baton Rouge, United States. In Comp Biochem Physiol B Biochem Mol Biol, Feb 2016
UNASSIGNED: Polyamines are a family of low molecular weight organic cations produced in part by the coordinated actions of arginase II (Arg II) and ornithine decarboxylase (Odc).
Vesicular Galectin-3 levels decrease with donor age and contribute to the reduced osteo-inductive potential of human plasma derived extracellular vesicles.
Grillari et al., Vienna, Austria. In Aging (albany Ny), Feb 2016
In particular osteogenic differentiation capacity (ODC) of mesenchymal stem cells (MSCs) has been shown to decrease with age, thereby contributing to reduced bone formation and an increased fracture risk.
Spatial and temporal distribution of genes involved in polyamine metabolism during tomato fruit development.
Delis et al., Athens, Greece. In Plant Physiol Biochem, Feb 2016
In the present study, the expression profile, the accumulation of free polyamines and the transcript localisation of the genes involved in Put metabolism, such as Ornithine decarboxylase (ODC), Arginine decarboxylase (ADC) and copper containing Amine oxidase (CuAO), were examined during Solanum lycopersicum cv.
Simultaneous biosynthesis of putrebactin, avaroferrin and bisucaberin by Shewanella putrefaciens and characterisation of complexes with iron(III), molybdenum(VI) or chromium(V).
Codd et al., Sydney, Australia. In J Inorg Biochem, Jan 2016
UNASSIGNED: Cultures of Shewanella putrefaciens grown in medium containing 10mM 1,4-diamino-2-butanone (DBO) as an inhibitor of ornithine decarboxylase and 10mM 1,5-diaminopentane (cadaverine) showed the simultaneous biosynthesis of the macrocyclic dihydroxamic acids: putrebactin (pbH2), avaroferrin (avH2) and bisucaberin (bsH2).
Mobile Phone Radiation: Physiological & Pathophysiologcal Considerations.
K Sri, In Indian J Physiol Pharmacol, Apr 2015
Pathophysiological mechanisms of interaction of EMR at plasma membrane are calcium efflux from cell membranes, increased expression of stress proteins, influence on channels/gap junctions in cell membrane, overproduction of reactive oxygen species, ornithine decarboxylase activation, reduction in melatonin levels, decrease in protein kinase C activity, damage to DNA and change in gene expression in brain cells and altered blood-brain barrier.
TP53 modulating agent, CP-31398 enhances antitumor effects of ODC inhibitor in mouse model of urinary bladder transitional cell carcinoma.
Rao et al., Oklahoma City, United States. In Am J Cancer Res, 2014
We investigated the inhibition of polyamines biosynthesis and the restoration of p53 signaling as a possible means of preventing muscle invasive urothelial tumors using DFMO, an ODC-inhibiting agent, and CP-31398 (CP), a p53 stabilizing agent.
The relevance of piroxicam for the prevention and treatment of nonmelanoma skin cancer and its precursors.
Orlandi et al., Roma, Italy. In Drug Des Devel Ther, 2014
The drug suppresses the synthesis of proinflammatory enzymes, such as cyclo-oxygenases-1 and -2 (COX-1 and 2), downregulates the production of prostaglandins (PGs) and tromboxanes, and inhibits polyamines production by blocking ornithine decarboxylase induction involved in nonmelanoma skin carcinogenesis.
Targeting polyamine metabolism for finding new drugs against leishmaniasis: a review.
Colotti et al., Roma, Italy. In Mini Rev Med Chem, 2014
The enzymes, belonging to the spermidine metabolism, i.e. arginase (ARG), ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase (AdoMetDC), spermidine synthase (SpdS), trypanothione synthetase (TryS or TSA), trypanothione reductase (TryR or TR), tryparedoxin peroxidase (TXNPx), deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase (DOHH) are promising targets for the development of new drugs against leishmaniasis.
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
Kahn et al., Boston, United States. In Nature, 2014
Polyamine flux including synthesis, catabolism and excretion, is controlled by the rate-limiting enzymes ornithine decarboxylase (ODC) and spermidine-spermine N(1)-acetyltransferase (SSAT; encoded by Sat1) and by polyamine oxidase (PAO), and has a major role in energy metabolism.
[The importance of putrescine in the human body].
Lachowski et al., Laizhou, China. In Postepy Hig Med Dosw (online), 2013
Especially important for the homeostasis of putrescine has ornithine decarboxylase and availability of its substrate--ornithine. Affecting to this enzyme is the simplest and widely used method of controlling the concentration of putrescine.
Vitamin B6-dependent enzymes in the human malaria parasite Plasmodium falciparum: a druggable target?
Wrenger et al., São Paulo, Brazil. In Biomed Res Int, 2013
The active form of vitamin B6, pyridoxal 5-phosphate, is, besides its antioxidative properties, a cofactor for a variety of essential enzymes present in the malaria parasite which includes the ornithine decarboxylase (ODC, synthesis of polyamines), the aspartate aminotransferase (AspAT, involved in the protein biosynthesis), and the serine hydroxymethyltransferase (SHMT, a key enzyme within the folate metabolism).
Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma.
Guan et al., Hong Kong, Hong Kong. In Nat Med, 2013
Compared with wild-type AZIN1 protein, the edited form has a stronger affinity to antizyme, and the resultant higher AZIN1 protein stability promotes cell proliferation through the neutralization of antizyme-mediated degradation of ornithine decarboxylase (ODC) and cyclin D1 (CCND1).
Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway.
Robins et al., Leuven, Belgium. In J Biol Chem, 2012
Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway.
Variants downstream of the ornithine decarboxylase gene influence risk of colorectal adenoma and aspirin chemoprevention.
Baron et al., United States. In Cancer Prev Res (phila), 2011
Variants of the ornithine decarboxylase gene influence risk of colorectal adenoma and aspirin chemoprevention.
Mechanism of formation of the internal aldimine in pyridoxal 5'-phosphate-dependent enzymes.
Ramos et al., Porto, Portugal. In J Am Chem Soc, 2011
the mechanism of formation of the internal aldimine, a common intermediate to most pyridoxal 5'-phosphate (PLP)-dependent enzymes
Polyamine sensing by nascent ornithine decarboxylase antizyme stimulates decoding of its mRNA.
Dohmen et al., Köln, Germany. In Nature, 2011
Regulation of polyamine synthesis is mainly achieved by controlling the activity of ornithine decarboxylase (ODC) through an unusual mechanism involving ODC antizyme, the binding of which disrupts homodimeric ODC and targets it for ubiquitin-independent degradation by the 26S proteasome.
Critical factors governing the difference in antizyme-binding affinities between human ornithine decarboxylase and antizyme inhibitor.
Hung et al., T'ai-chung-shih, Taiwan. In Plos One, 2010
the differences in residues 125 and 140 in ODC and AZI are responsible for the differential antizyme-binding affinities
Minimal antizyme peptide fully functioning in the binding and inhibition of ornithine decarboxylase and antizyme inhibitor.
Hung et al., T'ai-chung-shih, Taiwan. In Plos One, 2010
AZ_95-176 is the minimal AZ peptide that is fully functioning in the binding of ODC and AZI and inhibition of their function.
Arginine decarboxylase and polyamines required for embryogenesis in the wild carrot.
Litvay et al., In Science, 1984
Embryogenesis was not significantly affected by alpha-difluoromethylornithine, an inhibitor of ornithine decarboxylase.
Polyamines and plant stress: activation of putrescine biosynthesis by osmotic shock.
Galston et al., In Science, 1982
Increased arginine decarboxylase activity parallels the rise in putrescine, whereas ornithine decarboxylase remains unchanged.
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