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Ornithine aminotransferase

ornithine aminotransferase, OAT
This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome. [provided by RefSeq, Jan 2010] (from NCBI)
Top mentioned proteins: ACID, HAD, CAN, V1a, Arginase
Papers on ornithine aminotransferase
Contribution of polyamines metabolism and GABA shunt to chilling tolerance induced by nitric oxide in cold-stored banana fruit.
Ying et al., Hangzhou, China. In Food Chem, May 2016
Besides, NO treatment upregulated proline content and significantly enhanced the ornithine aminotransferase activity.
Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice.
Petersen et al., Aurora, United States. In Redox Biol, Apr 2016
Among the peptides/proteins identified, ACSL, ACOX2, MTP, and THIKB contribute to regulation of fatty acid metabolism and ARG1, ARLY, and OAT, which regulate nitrogen and ammonia metabolism having direct relevance to ethanol-induced liver injury.
l-Arginine metabolism in cardiovascular and renal tissue from hyper- and hypothyroid rats.
Vargas et al., Granada, Spain. In Exp Biol Med (maywood), Jan 2016
Enzymes studied were NOS isoforms (neuronal [nNOS], inducible [iNOS], and endothelial [eNOS]), arginases I and II, ornithine decarboxylase (ODC), ornithine aminotransferase (OAT), and l-arginine decarboxylase (ADC).
Association of the methylenetetrahydrofolate reductase gene C677T polymorphism with the risk of male infertility: a meta-analysis.
Wang et al., Shanghai, China. In Ren Fail, Dec 2015
Meanwhile, no significantly increased risks of oligoasthenotertozoospermia (OAT) were found in most of the genetic models.
A Balancing Act: Stability versus Reactivity of Mn(O) Complexes.
Goldberg et al., Baltimore, United States. In Acc Chem Res, Nov 2015
Addition of anionic donors to the Mn(V)(O) complex also leads to enhanced reactivity, with a large increase in the rate of two-electron oxygen atom transfer (OAT) to thioether substrates.
Synthetic mononuclear nonheme iron-oxygen intermediates.
Nam, Seoul, South Korea. In Acc Chem Res, Sep 2015
In the case of iron-superoxo complexes, an iron(III)-superoxo complex, [(TAML)Fe(III)(O2)](2-), is described, including its crystal structure and reactivities in electrophilic and nucleophilic oxidative reactions, and its properties are compared with those of a chromium(III)-superoxo complex, [(TMC)Cr(III)(O2)(Cl)](+), with respect to its reactivities in hydrogen atom transfer (HAT) and oxygen atom transfer (OAT) reactions.
Ornithine aminotransferase versus GABA aminotransferase: implications for the design of new anticancer drugs.
Silverman et al., Evanston, United States. In Med Res Rev, Mar 2015
Ornithine aminotransferase (OAT) and γ-aminobutyric acid aminotransferase (GABA-AT) are classified under the same evolutionary subgroup and share a large portion of structural, functional, and mechanistic features.
The organic anion transporter (OAT) family: a systems biology perspective.
Wu et al., San Diego, United States. In Physiol Rev, 2015
The organic anion transporter (OAT) subfamily, which constitutes roughly half of the SLC22 (solute carrier 22) transporter family, has received a great deal of attention because of its role in handling of common drugs (antibiotics, antivirals, diuretics, nonsteroidal anti-inflammatory drugs), toxins (mercury, aristolochic acid), and nutrients (vitamins, flavonoids).
Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs.
Nigam et al., San Diego, United States. In Plos One, 2014
Many OAT members were found to appear after a major expansion of the SLC22 family in mammals, suggesting a physiological and/or toxicological role during the mammalian radiation.
Modulation of L-Arginine-Arginase Metabolic Pathway Enzymes: Immunocytochemistry and mRNA Expression in Peripheral Blood and Tissue Levels in Head and Neck Squamous Cell Carcinomas in North East India.
Ghosh et al., Silchar, India. In Asian Pac J Cancer Prev, 2014
MATERIALS AND METHODS: The expressions of arginase isoforms (ARG1 and ARG2), ornithine aminotransferase (OAT) and ornithine decarboxylase (ODC) were examined in fifty paired HNSCC and adjacent non-tumor tissues by immunohistochemistry. Immunocytochemistry, semiquantitative reverse transcription sq-PCR and quantitative real-time qPCR were used to assess protein and mRNA expressions in peripheral blood of fifty HNSCC patients and hundred controls.
Preadmission oral anticoagulant therapy and clinical outcome in patients hospitalised with acute stroke and atrial fibrillation.
Johnsen et al., Århus, Denmark. In Dan Med J, 2014
INTRODUCTION: Information about the effect of preadmission oral anticoagulant therapy (OAT) on stroke outcome in patients with atrial fibrillation (AF) is scarce.
Drug transporters in the nasal epithelium: an overview of strategies in targeted drug delivery.
Agu et al., Halifax, Canada. In Future Med Chem, 2013
In this article, we discussed the expression of some ABC (e.g., P-glycoprortein, MRP and CFTR) and SLC (e.g., POT, DAT, OAT, OATP, OCT, EAAT2/GLT1 and GLUT) amino acid, metal and nucleoside transporters in the nasal mucosa.
[Treatment of very old patients with non valvular atrial fibrillation. The valuable opportunity offered by new oral anticoagulants, to be cautiously used].
Fattirolli et al., In Monaldi Arch Chest Dis, 2013
Advanced age is a risk factor for stroke in AF, but despite clear evidences a high rate of OAT under prescription is reported and particularly in the oldest old.
Gyrate atrophy: clinical and genetic findings in a female without arginine-restricted diet during her first 39 years of life and report of a new OAT gene mutation.
Jägle et al., Berlin, Germany. In Doc Ophthalmol, 2012
Molecular analysis revealed a new deletion c.532_536delTGGGG (p.Trp178X) and a known mutation c.897C>G (p.Tyr299X) in the OAT gene.
Retinal structure, function, and molecular pathologic features in gyrate atrophy.
Webster et al., London, United Kingdom. In Ophthalmology, 2012
Fundus autofluorescence imaging can reveal the extent of neurosensory dysfunction in gyrate atrophy patients.
Adaptative response of nitrogen metabolism in early endotoxemia: role of ornithine aminotransferase.
De Bandt et al., Paris, France. In Amino Acids, 2010
The data highlight the importance of OAT in ornithine metabolism, especially in the liver, and suggest a post-transcriptional regulation of OAT by LPS in the liver.
Xenobiotic, bile acid, and cholesterol transporters: function and regulation.
Aleksunes et al., Kansas City, United States. In Pharmacol Rev, 2010
Transporters of the solute carrier family (SLC) comprise a variety of proteins, including organic cation transporters (OCT) 1 to 3, organic cation/carnitine transporters (OCTN) 1 to 3, organic anion transporters (OAT) 1 to 7, various organic anion transporting polypeptide isoforms, sodium taurocholate cotransporting polypeptide, apical sodium-dependent bile acid transporter, peptide transporters (PEPT) 1 and 2, concentrative nucleoside transporters (CNT) 1 to 3, equilibrative nucleoside transporter (ENT) 1 to 3, and multidrug and toxin extrusion transporters (MATE) 1 and 2, which mediate the uptake (except MATEs) of organic anions and cations as well as peptides and nucleosides.
Sex-differential expression of ornithine aminotransferase in the mouse kidney.
Cynober et al., Lyon, France. In Am J Physiol Renal Physiol, 2007
Sexual dimorphism of Oat expression in the kidney was observed.
Hepatic HNF4alpha deficiency induces periportal expression of glutamine synthetase and other pericentral enzymes.
Lamers et al., Amsterdam, Netherlands. In Hepatology, 2007
In H4Flox liver, glutamine synthetase (GS), ornithine aminotransferase (OAT) and thyroid hormone-receptor beta1 (TRbeta1) were exclusively expressed in pericentral hepatocytes.
Quantitative trait transcripts for nicotine resistance in Drosophila melanogaster.
Gibson et al., Raleigh, United States. In Nat Genet, 2007
The strongest association was seen for abundance of ornithine aminotransferase transcripts, implicating detoxification and neurotransmitter biosynthesis as mediators of the quantitative response to the drug.
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