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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Opiate receptor-like 1

ORL1, oPRL, O or, nociceptin receptor, opioid receptor-like 1
orphan G-protein coupled receptor; may be a member of the opioid receptor gene family [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Neuropeptide, Prolactin, HAD, ACID, V1a
Papers on ORL1
Estradiol Rapidly Attenuates ORL-1 Receptor-Mediated Inhibition of Proopiomelanocortin Neurons via Gq-Coupled, Membrane-Initiated Signaling.
New
Wagner et al., Pomona, United States. In Neuroendocrinology, Feb 2016
Orphanin FQ/nociceptin (OFQ/N) acts via opioid receptor-like (ORL)-1 receptors to inhibit these POMC neurons.
A Novel Nociceptin Receptor Antagonist LY2940094 Inhibits Excessive Feeding Behavior in Rodents: A Possible Mechanism For The Treatment of Binge Eating Disorder.
New
Pintar et al., Le Robert, Martinique. In J Pharmacol Exp Ther, Jan 2016
UNASSIGNED: Nociceptin/Orphanin FQ (N/OFQ), a 17 amino acid peptide, is the endogenous ligand of the ORL1/Nociceptin-opioid-peptide (NOP) receptor.
"Nociceptin receptor activation does not alter acquisition, expression, extinction and reinstatement of conditioned cocaine preference in mice".
New
Brothers et al., Miami, United States. In Brain Res, Jan 2016
UNASSIGNED: Growing evidence indicates that targeting nociceptin receptor (NOP) signaling may have therapeutic efficacy in treating alcohol and opioid addiction.
Nociceptin/orphanin FQ up-regulates P2X3 receptors in primary cultures of neonatal rat trigeminal ganglion neurons.
New
Lai et al., Chengdu, China. In Eur J Oral Sci, Dec 2015
Recent evidence indicates a nociceptive role of the nociceptin/orphanin FQ-opioid receptor-like receptor (N/OFQ-ORL1) system in craniofacial pain; however, the mechanisms of such an effect remain unclear.
Nociceptin and the nociceptin receptor in learning and memory.
Review
New
Andero, Atlanta, United States. In Prog Neuropsychopharmacol Biol Psychiatry, Nov 2015
This review summarizes the body of research focused on N/OFQ and its specific receptor, the nociceptin receptor (NOP receptor), in learning and memory, and its potential mechanisms of action, in which acetylcholine, NMDA receptor, and noradrenaline may be critical.
[Mitochondrial DNA Polymorphism in Different Populations of Spangled Orloff Chickens].
New
Sulimova et al., In Genetika, Sep 2015
Haplogroup E (haplotypes ORL-1, ORL-2, and ORL-3) was present in the majority of the studied individual, with the frequencies of 0.77 in the total sample and 0.47 in the VNIIGRZh farm population.
Modulatory influences of estradiol and other anorexigenic hormones on metabotropic, Gi/o-coupled receptor function in the hypothalamic control of energy homeostasis.
Review
New
Wagner et al., Pomona, United States. In J Steroid Biochem Mol Biol, Aug 2015
The peptide orphanin FQ/nociceptin (OFQ/N) activates opioid receptor-like (ORL)1 receptors to hyperpolarize and inhibit POMC neurons via the activation of postsynaptic G protein-gated, inwardly-rectifying (GIRK) channels.
Role of nociceptin/orphanin FQ in thermoregulation.
Review
New
Spampinato et al., Bologna, Italy. In Neuropeptides, Apr 2015
Nociceptin/Orphanin FQ (N/OFQ) is a 17-amino acid peptide that binds to the nociceptin receptor (NOP).
Endogenous nociceptin system involvement in stress responses and anxiety behavior.
Review
Fulford, Bristol, United Kingdom. In Vitam Horm, 2014
In our research, we have employed nociceptin receptor antagonists to investigate endogenous nociceptin function in tonic control over stress-induced activity of the hypothalamo-pituitary-adrenal axis.
Orphanin FQ-ORL-1 regulation of reproduction and reproductive behavior in the female.
Review
Sanathara et al., Long Beach, United States. In Vitam Horm, 2014
Orphanin FQ (OFQ/N) and its receptor, opioid receptor-like receptor-1 (ORL-1), are expressed throughout steroid-responsive limbic and hypothalamic circuits that regulate female ovarian hormone feedback and reproductive behavior circuits.
Decreased plasma nociceptin/orphanin FQ levels after acute coronary syndromes.
GeneRIF
Tekes et al., Budapest, Hungary. In Acta Physiol Hung, 2012
Decreased plasma nociceptin/orphanin FQ is closely associated with the presence of acute cardiovascular disease, and the severity of symptoms has a significant negative correlation with the N/OFQ levels.
Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic.
Impact
GeneRIF
Stevens et al., Los Angeles, United States. In Nature, 2012
crystal structure of human NOP (also known as ORL-1), solved in complex with the peptide mimetic antagonist compound-24
Nociceptin/orphanin FQ inhibition with SB612111 ameliorates dextran sodium sulfate-induced colitis.
GeneRIF
D'Andrea et al., Menlo Park, United States. In Eur J Pharmacol, 2012
Data suggest that nociceptin receptor/nociceptin signaling plays a role in the disease pathogenesis of inflammatory bowel diseases.
Opioid-related (ORL1) receptors are enriched in a subpopulation of sensory neurons and prolonged activation produces no functional loss of surface N-type calcium channels.
GeneRIF
Christie et al., Sydney, Australia. In J Physiol, 2012
ORL1 receptors are enriched in a subpopulation of sensory neurons and prolonged activation produces no functional loss of surface N-type calcium channels
Effects of intraplantar nocistatin and (±)-J 113397 injections on nociceptive behavior in a rat model of inflammation.
GeneRIF
Parenti et al., Catania, Italy. In Pharmacol Biochem Behav, 2012
Data suggest that peripheral nociceptin/orphanin FQ/NOP receptor/ligand system contributes to abnormal pain sensitivity in inflammatory states.
The molecular and behavioral pharmacology of the orphanin FQ/nociceptin peptide and receptor family.
Review
Impact
Pasternak et al., Montréal, Canada. In Pharmacol Rev, 2001
This heptadecapeptide binds to the NOP(1) (previously termed ORL1) receptor with exceedingly high affinity, but does not interact directly with classical opioid receptors.
Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors.
Impact
Takeshima et al., Tokyo, Japan. In Nature, 1998
The nociceptin receptor uses guanine-nucleotide-binding proteins to mediate the inhibition of adenylyl cyclase, the activation of potassium channels and inhibition of calcium channels.
Nocistatin, a peptide that blocks nociceptin action in pain transmission.
Impact
Ito et al., Moriguchi, Japan. In Nature, 1998
Although nocistatin does not bind to the nociceptin receptor, it binds to the membrane of mouse brain and of spinal cord with high affinity.
Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor.
Impact
Monsarrat et al., Toulouse, France. In Nature, 1995
The ORL1 receptor, an orphan receptor whose human and murine complementary DNAs have recently been characterized, structurally resembles opioid receptors and is negatively coupled with adenylate cyclase.
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