Origin Recognition Complex
ORC proteins in the mammalian zygote.
Honolulu, United States. In Cell Tissue Res, Jan 2016
The origin recognition complex (ORC) proteins, ORC1-6, are the first known proteins that bind DNA replication origins to mark the competency for the initiation of DNA synthesis.
Nijmegen, Netherlands. In Orphanet J Rare Dis, 2014
Mutations in one of five genes (ORC1, ORC4, ORC6, CDT1, and CDC6) of the pre-replication complex, involved in DNA-replication, are detected in approximately 67-78% of patients with MGS.
Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome.
Halifax, Canada. In Nat Genet, 2011
Using marker-assisted mapping in multiple families from a founder population and traditional coding exon sequencing of positional candidate genes, we identified three different mutations in the gene encoding ORC4, a component of the eukaryotic origin recognition complex, in five individuals with Meier-Gorlin syndrome.