Type III secretion system genes of Edwardsiella tarda associated with intracellular replication and virulence in zebrafish.
Hiroshima, Japan. In Dis Aquat Organ, 2014
Two possible effector candidate genes (eseE and eseG) and 7 hypothetical genes (esaB, escC, orf13, orf19, orf26, orf29, and orf30) located in the T3SS gene cluster were inactivated by an allelic exchange method, and we found that E. tarda strains carrying insertion mutations in escC, orf13, orf19, orf29, and orf30 were unable to replicate within J774 macrophages and HEp-2 epithelial cells.
Seattle, United States. In Unknown Journal, 2013
DIAGNOSIS/TESTING: The diagnosis of CED is established in those with typical clinical findings and can be confirmed in 40% of affected individuals by identification of biallelic mutations in one of the four genes known to be associated with CED: IFT122 (previously WDR10), WDR35 (IFT121), WDR19 (IFT144), or IFT43 (previously C14orf179).
The BBSome controls IFT assembly and turnaround in cilia.
Rochester, United States. In Nat Cell Biol, 2012
Further analyses revealed that the BBSome (refs 3, 4), a group of conserved proteins affected in human Bardet-Biedl syndrome(5) (BBS), assembles IFT complexes at the ciliary base, then binds to the anterograde IFT particle in a DYF-2- (an orthologue of human WDR19) and BBS-1-dependent manner, and lastly reaches the ciliary tip to regulate proper IFT recycling.
Ciliary disorder of the skeleton.
Paris, France. In Am J Med Genet C Semin Med Genet, 2012
Mutations have been identified in dynein motor (DYNC2H1), in intraflagellar transport (IFT) complexes (IFT80, IFT122, IFT43, WDR35, WDR19, and TTC21B) as well as in genes responsible for the basal body (NEK1, EVC, and EVC2).
Partial genome analysis of murine gammaherpesvirus 4556.
Bratislava, Slovakia. In Acta Virol, 2011
Due to these differences, immune evasion protein M4 and structural proteins encoded by ORF8 (gB), ORF11 (p43), ORF26 and ORF52, respectively, are predicted to have a reduced hydrophilicity and surface exposure compard with their MHV-68 counterparts.