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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

ORC6 Orc6p

Orc6, Orc6p, ORC6L
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: Origin Recognition Complex, Cdc6, Orc4, ORC2, orc5
Papers on Orc6
De Novo GMNN Mutations Cause Autosomal-Dominant Primordial Dwarfism Associated with Meier-Gorlin Syndrome.
Yang et al., Houston, United States. In Am J Hum Genet, Jan 2016
Meier-Gorlin syndrome (MGS) is a genetically heterogeneous primordial dwarfism syndrome known to be caused by biallelic loss-of-function mutations in one of five genes encoding pre-replication complex proteins: ORC1, ORC4, ORC6, CDT1, and CDC6.
Targeting of cytosolic phospholipase A2α impedes cell cycle re-entry of quiescent prostate cancer cells.
Dong et al., Australia. In Oncotarget, Nov 2015
Inhibition of cPLA2α also prevented an accumulation of cyclin D1/CDK4, cyclin E/CDK2, phospho-pRb, pre-replicative complex proteins CDC6, MCM7, ORC6 and DNA synthesis-related protein PCNA during induction of cell cycle re-entry.
ORC4 surrounds extruded chromatin in female meiosis.
Ward et al., Honolulu, United States. In J Cell Biochem, May 2015
Six proteins, ORC1-6, make up the origin recognition complex (ORC) that initiates licensing of DNA replication origins.
Further insight into the phenotype associated with a mutation in the ORC6 gene, causing Meier-Gorlin syndrome 3.
Elpeleg et al., Israel. In Am J Med Genet A, Mar 2015
We report on the identification of a homozygous deleterious mutation in the ORC6 gene in previously described fetuses at the severe end of the Meier-Gorlin spectrum.
Meier-Gorlin syndrome.
Bongers et al., Nijmegen, Netherlands. In Orphanet J Rare Dis, 2014
Mutations in one of five genes (ORC1, ORC4, ORC6, CDT1, and CDC6) of the pre-replication complex, involved in DNA-replication, are detected in approximately 67-78% of patients with MGS.
Computational identification of post-translational modification-based nuclear import regulations by characterizing nuclear localization signal-import receptor interaction.
Hu et al., United States. In Proteins, 2014
Application of this approach has identified the potential nuclear import regulation mechanisms by phosphorylation of two nuclear proteins including SF1 and ORC6.
The Arabidopsis transcription factor IIB-related protein BRP4 is involved in the regulation of mitotic cell-cycle progression during male gametogenesis.
Hu et al., Beijing, China. In J Exp Bot, 2014
Moreover, we showed that the level of expression of a gene encoding a subunit of the origin recognition complex, ORC6, was decreased in BRP4 knockdown plants, and that the ORC6 knockdown transgenic plants phenocopied the male gametophyte defect observed in BRP4 knockdown plants, suggesting that ORC6 acts downstream of BRP4 to mediate male mitotic progression.
Evidence of positive selection at codon sites localized in the C-terminal peptide of ORC6.
Bian et al., In Biotechnol Lett, 2014
Origin recognition complex 6 (Orc6) plays a central role in the initiation of DNA replication in all eukaryotic systems.
Structure and Expression Analyses of SVA Elements in Relation to Functional Genes.
Kim et al., Pusan, South Korea. In Genomics Inform, 2013
In an analysis of genomic structure, SVA elements are detected in the 5' untranslated region (UTR) of HGSNAT (SVA-B), MRGPRX3 (SVA-D), HYAL1 (SVA-F), TCHH (SVA-F), and ATXN2L (SVA-F) genes, while some elements are observed in the 3'UTR of SPICE1 (SVA-B), TDRKH (SVA-C), GOSR1 (SVA-D), BBS5 (SVA-D), NEK5 (SVA-D), ABHD2 (SVA-F), C1QTNF7 (SVA-F), ORC6L (SVA-F), TMEM69 (SVA-F), and CCDC137 (SVA-F) genes.
Diminished origin-licensing capacity specifically sensitizes tumor cells to replication stress.
Jeggo et al., Brighton, United Kingdom. In Mol Cancer Res, 2013
Similar results were observed following depletion of ORC6 or CDC6.
Deficiency in origin licensing proteins impairs cilia formation: implications for the aetiology of Meier-Gorlin syndrome.
Jeggo et al., Brighton, United Kingdom. In Plos Genet, 2012
Mutations in ORC1, ORC4, ORC6, CDT1, and CDC6, which encode proteins required for DNA replication origin licensing, cause Meier-Gorlin syndrome (MGS), a disorder conferring microcephaly, primordial dwarfism, underdeveloped ears, and skeletal abnormalities.
Meier-Gorlin syndrome: growth and secondary sexual development of a microcephalic primordial dwarfism disorder.
Bongers et al., Nijmegen, Netherlands. In Am J Med Genet A, 2012
Recently, mutations in the ORC1, ORC4, ORC6, CDT1, and CDC6 genes, encoding components of the pre-replication complex, have been identified.
Different roles of the human Orc6 protein in the replication initiation process.
Schepers et al., München, Germany. In Cell Mol Life Sci, 2011
findings show that Orc6 not only interacts with Orc1-Orc5 but also with the initiation factor Cdc6, and that Orc6 functions at different stages of the replication initiation process.
Mechanisms and pathways of growth failure in primordial dwarfism.
Jackson et al., Edinburgh, United Kingdom. In Genes Dev, 2011
Ten genes have now been identified for microcephalic primordial dwarfism, encoding proteins involved in fundamental cellular processes including genome replication (ORC1 [origin recognition complex 1], ORC4, ORC6, CDT1, and CDC6), DNA damage response (ATR [ataxia-telangiectasia and Rad3-related]), mRNA splicing (U4atac), and centrosome function (CEP152, PCNT, and CPAP).
Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB.
Liu et al., Beijing, China. In Proc Natl Acad Sci U S A, 2011
Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB.
Mutations in the pre-replication complex cause Meier-Gorlin syndrome.
Jackson et al., Edinburgh, United Kingdom. In Nat Genet, 2011
We report here that individuals with this disorder show marked locus heterogeneity, and we identify mutations in five separate genes: ORC1, ORC4, ORC6, CDT1 and CDC6.
CDK prevents Mcm2-7 helicase loading by inhibiting Cdt1 interaction with Orc6.
Bell et al., Cambridge, United States. In Genes Dev, 2011
The Orc6 RXL/cyclin-binding motif plays a positive role in the initial recruitment of Cdt1/Mcm2-7 to the origin, suggesting that this motif is critical for the switch between active and inhibited ORC function at the G1-to-S-phase transition.
Functional analysis of an Orc6 mutant in Drosophila.
Chesnokov et al., Birmingham, United States. In Proc Natl Acad Sci U S A, 2009
In a cross-species complementation experiment, the expression of human Orc6 in Drosophila Orc6 mutant cells rescued DNA replication, suggesting that this function of the protein is conserved among metazoans.
Reduction of Orc6 expression sensitizes human colon cancer cells to 5-fluorouracil and cisplatin.
Ju et al., Mobile, United States. In Plos One, 2007
Orc6 has a role in sensitizing human colon cancer cells to 5-fluorouracil and cisplatin
Isolation of ORC6, a component of the yeast origin recognition complex by a one-hybrid system.
Herskowitz et al., San Francisco, United States. In Science, 1994
Functional studies of the yeast homolog
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