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ORC5 Orc5p

orc5, Orc5p, ORC5L
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: ORC2, Origin Recognition Complex, Orc4, Orc6, CAN
Papers on orc5
Identification of E2F target genes that are rate limiting for dE2F1-dependent cell proliferation.
Dyson et al., United States. In Dev Dyn, 2012
One of the strongest of these suppressors was Orc5.
Gastric cancer cell lines AGS before and after CD40 signal activating.
Zhang et al., Suzhou, China. In Mol Biol Rep, 2012
To further verify the results of gene chip screening, Gene Database was searched, finding that the most significantly up-regulated genes were Gadd45a, c-Jun and Bcl-2, and the most significantly down-regulated genes were Cyclin D1, CDC6, TNFR10B, c-IAP2 and ORC5L.
The origin recognition complex subunit, ORC3, is developmentally regulated and supports the expression of biochemical markers of neuronal maturation in cultured cerebellar granule cells.
Melchiorri et al., Pavia, Italy. In Brain Res, 2010
However, some members of the ORC core, such as ORC3 and ORC5, have been implicated in neuronal maturation.
GCN5 is a positive regulator of origins of DNA replication in Saccharomyces cerevisiae.
Yankulov et al., Guelph, Canada. In Plos One, 2009
Here we show that the deletion of GCN5 decreases the stability of mini-chromosomes; that the tethering of Gcn5p to a crippled origin of replication stimulates its activity; that high dosage of GCN5 suppresses conditional phenotypes caused by mutant alleles of bona fide replication factors, orc2-1, orc5-1 and mcm5-461.
Linkage between phosphorylation of the origin recognition complex and its ATP binding activity in Saccharomyces cerevisiae.
Mizushima et al., Kumamoto, Japan. In J Biol Chem, 2009
Of the six subunits of the Saccharomyces cerevisiae ORC (Orc1-6p), both Orc1p and Orc5p have ATP binding activity, and both Orc2p and Orc6p are phosphorylated by CDK in cells.
Positive roles of SAS2 in DNA replication and transcriptional silencing in yeast.
Bi et al., Rochester, United States. In Nucleic Acids Res, 2008
We show here that SAS2 deletion (sas2Delta) exacerbates the temperature sensitivity of the ORC mutants orc2-1 and orc5-1.
Plasmodium falciparum origin recognition complex subunit 5: functional characterization and role in DNA replication foci formation.
Dhar et al., New Delhi, India. In Mol Microbiol, 2008
Interestingly, these proteins separate from each other at the non-replicating late schizont stage, citing the evidence of the presence of both PCNA and ORC components in replication foci during eukaryotic DNA replication.
Schizosaccharomyces pombe Orc5 plays multiple roles in the maintenance of genome stability throughout the cell cycle.
Murakami et al., Kyoto, Japan. In Cell Cycle, 2008
Orc5 is required for the initiation step of DNA replication.
Analysis of origin recognition complex in saccharomyces cerevisiae by use of Degron mutants.
Mizushima et al., Kumamoto, Japan. In J Biochem, 2008
When Orc5p (ORC) is depleted, this inhibits G1/S transition and formation of a pre-replicative complex (pre-RC).
Yeast two-hybrid analysis of the origin recognition complex of Saccharomyces cerevisiae: interaction between subunits and identification of binding proteins.
Mizushima et al., Kumamoto, Japan. In Fems Yeast Res, 2007
We also identified several proteins that interact with ORC subunits; Sir4p and Mad1p interact with Orc2p; Cac1p and Ykr077wp with Orc3p; Rrm3p and Swi6p with Orc5p; and Mih1p with Orc6p.
Interaction between ORC and Cdt1p of Saccharomyces cerevisiae.
Mizushima et al., Kumamoto, Japan. In Fems Yeast Res, 2007
In this study, yeast two-hybrid analysis was used to examine the interaction between Cdt1p and every ORC subunit; potent interaction with Orc6p, and weaker interaction with Orc2p and Orc5p was observed.
Mechanism for the degradation of origin recognition complex containing Orc5p with a defective Walker A motif and its suppression by over-production of Orc4p in yeast cells.
Mizushima et al., Kumamoto, Japan. In Biochem J, 2007
interaction is mediated by the C-terminal region of Orc4p, and the N-terminal region of Orc5p
Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex.
Botchan et al., Berkeley, United States. In Nat Struct Mol Biol, 2006
ATP-dependent conformational changes observed in ORC5 derive from reorientation of the domains
Roles for ORC in M phase and S phase.
Rine et al., Berkeley, United States. In Science, 1998
One subunit of ORC, Orc5p, was required at G1/S and in early M phase.
Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex.
Bell et al., Cambridge, United States. In Cell, 1997
The Origin Recognition Complex (ORC) is a six-protein assembly that specifies the sites of DNA replication initiation in S. cerevisiae.
A Drosophila homolog of the yeast origin recognition complex.
Botchan et al., Berkeley, United States. In Science, 1996
Genes from Drosophila melanogaster have been identified that encode proteins homologous to Orc2p and Orc5p of the Saccharomyces cerevisiae origin recognition complex (ORC).
ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome.
Stillman et al., New York City, United States. In Cell, 1995
The origin recognition complex (ORC) binds replicators in the yeast S. cerevisiae in a manner consistent with it being an initiator protein for DNA replication.
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