Gastric cancer cell lines AGS before and after CD40 signal activating.
Suzhou, China. In Mol Biol Rep, 2012
To further verify the results of gene chip screening, Gene Database was searched, finding that the most significantly up-regulated genes were Gadd45a, c-Jun and Bcl-2, and the most significantly down-regulated genes were Cyclin D1, CDC6, TNFR10B, c-IAP2 and ORC5L.
GCN5 is a positive regulator of origins of DNA replication in Saccharomyces cerevisiae.
Guelph, Canada. In Plos One, 2009
Here we show that the deletion of GCN5 decreases the stability of mini-chromosomes; that the tethering of Gcn5p to a crippled origin of replication stimulates its activity; that high dosage of GCN5 suppresses conditional phenotypes caused by mutant alleles of bona fide replication factors, orc2-1, orc5-1 and mcm5-461.