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Origin recognition complex, subunit 2

ORC2, Orc2p, ORP2
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate. [provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: Origin Recognition Complex, CAN, Cdc6, orc5, Histone
Papers on ORC2
Presence of the Paternal Pronucleus Assists Embryo in Overcoming Cycloheximide Induced Abnormalities in Zygotic Mitosis.
Ward et al., Honolulu, United States. In J Cell Biochem, Feb 2016
Here, we report that continuous cycloheximide [40 µg/mL] treatment of parthenogenotes, androgenotes, and ICSI embryos reveals ORC2 pronuclear instability in the maternal (MPN) but not the paternal pronucleus (PPN).
Mitochondrial transporters for ornithine and related amino acids: a review.
Palmieri et al., Bari, Italy. In Amino Acids, Sep 2015
The mitochondrial carriers ORC1, ORC2, and SLC25A29 from Homo sapiens, BAC1 and BAC2 from Arabidopsis thaliana, and Ort1p from Saccharomyces cerevisiae have been biochemically characterized by transport assays in liposomes.
Checkpoint Activation of an Unconventional DNA Replication Program in Tetrahymena.
Kapler et al., College Station, United States. In Plos Genet, Jul 2015
Here we describe an unprecedented ATR-dependent pathway in Tetrahymena thermophila in which the essential pre-replicative complex proteins, Orc1p, Orc2p and Mcm6p are degraded in hydroxyurea-treated S phase cells.
Sterol liganding of OSBP-related proteins (ORPs) regulates the subcellular distribution of ORP-VAPA complexes and their impacts on organelle structure.
Weber-Boyvat et al., Helsinki, Finland. In Steroids, Jul 2015
ORP2-VAPA complexes, which localize in untreated cells at blob-like ER structures with associated lipid droplets, were redistributed upon treatment with the ORP2 ligand 22(R)OHC to a diffuse cytoplasmic/ER pattern and the plasma membrane.
ORC4 surrounds extruded chromatin in female meiosis.
Ward et al., Honolulu, United States. In J Cell Biochem, May 2015
Six proteins, ORC1-6, make up the origin recognition complex (ORC) that initiates licensing of DNA replication origins.
Developmental regulation of the Tetrahymena thermophila origin recognition complex.
Kapler et al., College Station, United States. In Plos Genet, 2015
Here we present evidence for programmed changes in ORC and MCM abundance that are not consistent with conventional models for DNA replication.
Oxysterol-binding proteins: sterol and phosphoinositide sensors coordinating transport, signaling and metabolism.
Li et al., Helsinki, Finland. In Prog Lipid Res, 2013
The functions assigned for mammalian ORPs include coordination of sterol and sphingolipid metabolism and mitogenic signaling (OSBP), control of ER-late endosome (LE) contacts and LE motility (ORP1L), neutral lipid metabolism (ORP2), cell adhesion (ORP3), cholesterol eggress from LE (ORP5), macrophage lipid homeostasis, migration and high-density lipoprotein metabolism (ORP8), apolipoprotein B-100 secretion (ORP10), and adipogenesis (ORP11).
[Chromomeric organization of interphase chromosomes in Drosophila melanogaster].
Pokholkiova et al., In Tsitologiia, 2012
In the interbands of both chromosome types we find the proteins that control initiation of transcription (RNA-polymerase II, transcription factors), replication (ORC2) as well as proteins modifying nucleosome structure (WDS, NURF) and proteins of insulators (BEAF).
Phosphorylation of ORC2 protein dissociates origin recognition complex from chromatin and replication origins.
Hwang et al., Seoul, South Korea. In J Biol Chem, 2012
The phosphorylation of ORC2 dissociates origin recognition complex (ORC) from chromatin and replication origins and inhibits binding of ORC to newly replicated DNA.
Substrate specificity of the two mitochondrial ornithine carriers can be swapped by single mutation in substrate binding site.
Palmieri et al., Bari, Italy. In J Biol Chem, 2012
characterized mutations of the proposed substrate binding site in ORC1 and ORC2; demonstrated that the residue at position 179 in the 2 soforms is largely responsible for the difference in their substrate specificity;concluded that Arg-179 is a key residue in the opening of the carrier to the matrix side
Plk1 phosphorylation of Orc2 promotes DNA replication under conditions of stress.
Liu et al., West Lafayette, United States. In Mol Cell Biol, 2011
Plk1 phosphorylation of Orc2 promotes DNA replication under conditions of stress
OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids.
Olkkonen et al., Helsinki, Finland. In J Lipid Res, 2009
Results identify ORP2 as a sterol receptor present on LD and provide evidence for its role in the regulation of neutral lipid metabolism, possibly as a factor that integrates the cellular metabolism of triglycerides with that of cholesterol.
Binding of Drosophila ORC proteins to anaphase chromosomes requires cessation of mitotic cyclin-dependent kinase activity.
Gossen et al., Berlin, Germany. In Mol Cell Biol, 2009
Cessation of mitotic cyclin-dependent kinase activity is essential for binding of the DmOrc proteins to chromosomes.
Molecular and structural transactions at human DNA replication origins.
Riva et al., Trieste, Italy. In Cell Cycle, 2007
Some of the involved proteins have been identified (and particularly the essential six-protein Origin Recognition Complex, ORC) thanks to their homology with the proteins identified in yeast.
Latent and lytic Epstein-Barr virus replication strategies.
Kudoh et al., Nagoya, Japan. In Rev Med Virol, 2005
In the latent state, the EBV genomic DNA, which exists as a closed circular plasmid, appears to behave just like host chromosomal DNA and it has been demonstrated recently that replication of OriP-containing plasmids is indeed dependent on the chromosomal initiation factors, ORC2 and Cdt1.
Chromatin regulates origin activity in Drosophila follicle cells.
Calvi et al., Philadelphia, United States. In Nature, 2004
We find that histones at the active origins are hyperacetylated, coincident with binding of the origin recognition complex (ORC).
The Drosophila HOAP protein is required for telomere capping.
Gatti et al., Roma, Italy. In Nat Cell Biol, 2003
HOAP (HP1/ORC-associated protein) has recently been isolated from Drosophila melanogaster embryos as part of a cytoplasmic complex that contains heterochromatin protein 1 (HP1) and the origin recognition complex subunit 2 (ORC2).
Stable association of mitotic cyclin B/Cdc2 to replication origins prevents endoreduplication.
Millar et al., London, United Kingdom. In Cell, 2002
Cells expressing an orp2 (ORC2) allele that reduces binding of Cdc13 to replication origins are acutely prone to chromosomal reduplication.
Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin.
Dutta et al., Boston, United States. In Cell, 2001
A hypomorphic mutation made in the ORC2 gene of a human cancer cell line through homologous recombination decreased Orc2 protein levels by 90%.
Regulation of DNA-replication origins during cell-cycle progression.
Yoshikawa et al., Ikoma, Japan. In Nature, 1998
We also find that orc2, which encodes subunit 2 of the origin-recognition complex, is involved in suppression of late origins.
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