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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

ORAI calcium release-activated calcium modulator 2

Orai2
Top mentioned proteins: Orai1, Sim, STIM2, CAN, V1a
Papers on Orai2
STIM and ORAI proteins in the nervous system.
Review
New
Kraft, Leipzig, Germany. In Channels (austin), Oct 2015
Depletion of endoplasmic reticulum calcium stores activates STIM proteins which, in turn, bind and open calcium channels in the plasma membrane formed by the proteins ORAI1, ORAI2, and ORAI3.
Dental enamel cells express functional SOCE channels.
Lacruz et al., New York City, United States. In Sci Rep, 2014
Investigating primary murine enamel cells, we found that key components of CRAC channels (ORAI1, ORAI2, ORAI3, STIM1, STIM2) were expressed and most abundant during the maturation stage of enamel development.
A reciprocal shift in transient receptor potential channel 1 (TRPC1) and stromal interaction molecule 2 (STIM2) contributes to Ca2+ remodeling and cancer hallmarks in colorectal carcinoma cells.
Villalobos et al., Valladolid, Spain. In J Biol Chem, 2014
Tumor cells display increased expression of TRPC1, ORAI1, ORAI2, ORAI3, and STIM1.
The ryanodine receptor agonist 4-chloro-3-ethylphenol blocks ORAI store-operated channels.
Xu et al., Kingston upon Hull, United Kingdom. In Br J Pharmacol, 2014
In the HEK293 T-REx cells overexpressing STIM1/ORAI1-3, 4-CEP inhibited the ORAI1, ORAI2 and ORAI3 currents evoked by thapsigargin.
Regulators of calcium homeostasis identified by inference of kinetic model parameters from live single cells perturbed by siRNA.
Meyer et al., Stanford, United States. In Sci Signal, 2013
Furthermore, we showed that the Alzheimer's disease-linked protein presenilin-2 and the channel protein ORAI2 prevented overload of ER Ca(2+) and that feedback from Ca(2+) to phosphatidylinositol 4-kinase and PLCδ (phospholipase Cδ) may regulate the abundance of the plasma membrane lipid PI(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to control Ca(2+) extrusion.
Evidence of a functional estrogen receptor in parathyroid adenomas.
Larsson et al., Stockholm, Sweden. In J Clin Endocrinol Metab, 2012
In cultured cells, significantly increased numbers of genes with modified expression were detected after 48 h, compared to 24-h treatments with DPN or 4-hydroxytamoxifen, including the parathyroid-related genes CASR, VDR, JUN, CALR, and ORAI2.
Regulation of lymphocyte function by ORAI and STIM proteins in infection and autoimmunity.
Review
Feske et al., New York City, United States. In J Physiol, 2012
Store-operated Ca(2+) entry (SOCE) in cells of the immune system is mediated by Ca(2+) release-activated Ca(2+) (CRAC) channels that are formed by ORAI1 and its homologues ORAI2 and ORAI3.
Physiological and pathophysiological functions of SOCE in the immune system.
Review
Feske et al., New York City, United States. In Front Biosci (elite Ed), 2011
SOCE in immune cells is mediated by the highly Ca²⁺ selective Ca²⁺-release-activated Ca²⁺ (CRAC) channel, encoded by ORAI1, ORAI2 and ORAI3 genes.
Expression of Orai genes and I(CRAC) activation in the human retinal pigment epithelium.
GeneRIF
Strauss et al., Hamburg, Germany. In Graefes Arch Clin Exp Ophthalmol, 2011
With these data we show a new Ca(2)(+) entry pathway linked to the Ca(2)(+)/inositolphosphate second-messenger system in RPE cells which help to further understand regulatory pathways of agonists.
ORAI-mediated calcium entry: mechanism and roles, diseases and pharmacology.
Review
Monteith et al., Brisbane, Australia. In Pharmacol Ther, 2010
Isoforms of these proteins ORAI2, ORAI3 and STIM2 also have roles in cellular calcium homeostasis but are less well characterized.
Pharmacology of ORAI channels as a tool to understand their physiological functions.
Peinelt et al., Homburg, Germany. In Expert Rev Clin Pharmacol, 2010
The three human members, ORAI1, ORAI2 and ORAI3, are activated through the stromal interaction molecules (STIM)1 and 2 following depletion of endoplasmic reticulum Ca(2+) stores.
ORAI1 deficiency and lack of store-operated Ca2+ entry cause immunodeficiency, myopathy, and ectodermal dysplasia.
Feske et al., New York City, United States. In J Allergy Clin Immunol, 2009
METHODS: DNA sequence analysis for mutations in the genes ORAI1, ORAI2, ORAI3, and stromal interaction molecule (STIM) 1 and 2, as well as mRNA and protein expression analysis of ORAI1 in immunodeficient patients.
Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels.
GeneRIF
Muallem et al., Dallas, United States. In Proc Natl Acad Sci U S A, 2009
Data show that the fast Ca(2+)-dependent inactivation is mediated by three conserved glutamates in the C termini (CT) of Orai2 and Orai3, which show prominent fast Ca(2+)-dependent inactivation compared with Orai1.
Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant.
GeneRIF
Romanin et al., Linz, Austria. In J Biol Chem, 2009
analysis of activation of Orai1-3 channels by a STIM1 coiled-coil mutant
2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels.
GeneRIF
Penner et al., Honolulu, United States. In J Physiol, 2008
The effects of 2-aminoethoxydiphenyl borate on orai1, orai2, orai3 metabolism in HEK293 cells with and without STIM1 are reported.
Primary structure, chromosomal localization and expression in immune cells of the murine ORAI and STIM genes.
Flockerzi et al., Homburg, Germany. In Cell Calcium, 2007
The mouse genome contains four genes which encode the ORAI1, ORAI2 and ORAI3 proteins and two genes which encode the type I single-pass transmembrane STIM1 and STIM2 proteins.
Murine ORAI2 splice variants form functional Ca2+ release-activated Ca2+ (CRAC) channels.
Flockerzi et al., Homburg, Germany. In J Biol Chem, 2007
The present study focuses on the genomic organization, tissue expression pattern, and functional properties of the murine ORAI2.
Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels.
GeneRIF
Putney et al., United States. In J Biol Chem, 2007
Results suggest that Orai1, -2, and -3 channels are similarly inhibited by extracellular calcium, indicating similar affinities for Ca(2+) within the selectivity filter.
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