STIM and ORAI proteins in the nervous system.
Leipzig, Germany. In Channels (austin), Oct 2015
Depletion of endoplasmic reticulum calcium stores activates STIM proteins which, in turn, bind and open calcium channels in the plasma membrane formed by the proteins ORAI1, ORAI2, and ORAI3.
Dental enamel cells express functional SOCE channels.
New York City, United States. In Sci Rep, 2014
Investigating primary murine enamel cells, we found that key components of CRAC channels (ORAI1, ORAI2, ORAI3, STIM1, STIM2) were expressed and most abundant during the maturation stage of enamel development.
Evidence of a functional estrogen receptor in parathyroid adenomas.
Stockholm, Sweden. In J Clin Endocrinol Metab, 2012
In cultured cells, significantly increased numbers of genes with modified expression were detected after 48 h, compared to 24-h treatments with DPN or 4-hydroxytamoxifen, including the parathyroid-related genes CASR, VDR, JUN, CALR, and ORAI2.