The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011] (from
Tepikin Alexei V. et al., In Pflugers Archiv, 1994
... cDNA was then used as a template in PCR reactions to amplify full-length human STIM1 or ORAI1 using specific primers (below) containing restriction endonuclease sites to permit subsequent sub-cloning into the C-terminally tagging pEYFP-N1 vector (Clontech, Palo Alto, USA) or ...
Blair et al., Pittsburgh, United States. In Lab Invest, 2012
Micro-CT showed reduced cortical ossification and thinned trabeculae in Orai1(-/-) animals compared with controls; bone deposition was markedly decreased in the knockout mice. This suggests a previously unrecognized role for Orai1 within osteoblasts.