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ORAI calcium release-activated calcium modulator 1

Orai1, CRACM1
The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011] (from NCBI)
Papers using Orai1 antibodies
Rapid inactivation of depletion-activated calcium current (ICRAC) due to local calcium feedback
Supplier
Tepikin Alexei V. et al., In Pflugers Archiv, 1994
... cDNA was then used as a template in PCR reactions to amplify full-length human STIM1 or ORAI1 using specific primers (below) containing restriction endonuclease sites to permit subsequent sub-cloning into the C-terminally tagging pEYFP-N1 vector (Clontech, Palo Alto, USA) or ...
Papers on Orai1
Gene disruption of the calcium channel Orai1 results in inhibition of osteoclast and osteoblast differentiation and impairs skeletal development.
GeneRIF
Blair et al., Pittsburgh, United States. In Lab Invest, 2012
Micro-CT showed reduced cortical ossification and thinned trabeculae in Orai1(-/-) animals compared with controls; bone deposition was markedly decreased in the knockout mice. This suggests a previously unrecognized role for Orai1 within osteoblasts.
Overexpression of Orai1 and STIM1 proteins alters regulation of store-operated Ca2+ entry by endogenous mediators.
GeneRIF
Bolotina et al., Boston, United States. In J Biol Chem, 2012
Variation of expression levels of Orai1 or STIM1 can significantly alter expression and role of some endogenous regulators of store operated calcium entry.
Platelet-derived growth factor maintains stored calcium through a nonclustering Orai1 mechanism but evokes clustering if the endoplasmic reticulum is stressed by store depletion.
GeneRIF
Beech et al., Leeds, United Kingdom. In Circ Res, 2012
Suggest that PDGF has a nonclustering mechanism by which to activate Orai1 channels and maintain calcium stores replete.
Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1).
GeneRIF
Gwack et al., Los Angeles, United States. In Proc Natl Acad Sci U S A, 2012
Data show that junctate (ASPH) is an interacting partner of Orai1-STIM1 complex.
The association between single-nucleotide polymorphisms of ORAI1 gene and breast cancer in a Taiwanese population.
GeneRIF
Hou et al., Kao-hsiung, Taiwan. In Scientificworldjournal, 2011
We showed that genetic polymorphisms of ORAI1 associated strongly with lymph nodal involvement and estrogen receptors (ERs) positive breast cancer patients in a Taiwanese population.
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