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Olfactory receptor, family 1, subfamily G, member 1

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, somatostatin, SA2, TRPA1, T2R1
Papers on OR1G1
Predicted 3D structures of olfactory receptors with details of odorant binding to OR1G1.
Goddard et al., Pasadena, United States. In J Comput Aided Mol Des, 2014
We predict the ensemble of low energy structures for the human OR1G1 (hOR1G1) and also for six other diverse ORs, using the G protein-coupled receptor Ensemble of Structures in Membrane BiLayer Environment complete sampling method that samples 13 trillion different rotations and tilts using four different templates to predict the 24 structures likely to be important in binding and activation.
How broadly tuned olfactory receptors equally recognize their agonists. Human OR1G1 as a test case.
Golebiowski et al., Nice, France. In Cell Mol Life Sci, 2012
The molecular features that dominate the binding mode of agonists by a broadly tuned olfactory receptor are analyzed through a joint approach combining cell biology, calcium imaging, and molecular modeling.
Effects of luminal thymol on epithelial transport in human and rat colon.
Kuwahara et al., Shizuoka, Japan. In Am J Physiol Gastrointest Liver Physiol, 2011
OR1G1 and TRPA1 expression was investigated in isolated colonic mucosa by RT-PCR.
Relationships between molecular structure and perceived odor quality of ligands for a human olfactory receptor.
Tromelin et al., Jouy-le-Moutier, France. In Chem Senses, 2008
OR1G1 recognizes a group of odorants that share both 3D structural and perceptual qualities.
Luminal regulation of normal and neoplastic human EC cell serotonin release is mediated by bile salts, amines, tastants, and olfactants.
Pfragner et al., New Haven, United States. In Am J Physiol Gastrointest Liver Physiol, 2008
RT-PCR identified transcripts for T2R1 (bitter), OR1G1 (class II olfactory) and trace amine (TAR1) G protein-coupled receptors (GPCRs) and transporters for glutamine (SNAT1/2), glucose (GLUT1/3/SGLT1), and bile salts (ABST).
Comparison of odorant specificity of two human olfactory receptors from different phylogenetic classes and evidence for antagonism.
Briand et al., Jouy-le-Moutier, France. In Chem Senses, 2005
The class II OR1G1 was revealed to be broadly tuned towards odorants of 9-10 carbon chain length, with diverse functional groups.
Porcine odorant-binding protein selectively binds to a human olfactory receptor.
Ronin et al., Marseille, France. In Chem Senses, 2002
OR17-209 fails to bind to the pig odorant-binding protein, while OR17-201 exhibits specific saturable binding
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