Human Leukocyte Antigen Mismatch and Steroid Maintenance in Kidney Transplantation.
Pittsburgh, United States. In Transplant Proc, Dec 2015
METHODS: Adult KTRs between 2001 and 2011 who received antibody induction followed by calcineurin inhibitor (CNI)/mycophenolate mofetil (MMF) maintenance with or without steroid were identified from the Organ Procurement and Transplantation Network/United Network for Organ Sharing (OPTN/UNOS) database.
Expanding the ubiquitin code through post-translational modification.
Frankfurt am Main, Germany. In Embo Rep, Sep 2015
Similarly, TBK1 phosphorylates the autophagy receptors OPTN and p62 to initiate feedback and feedforward programs for Ub-dependent removal of protein aggregates, mitochondria and pathogens (such as Salmonella and Mycobacterium tuberculosis).
Genetics of Paget's disease of bone.
Edinburgh, United Kingdom. In Bonekey Rep, 2014
Other susceptibility loci have highlighted new molecular pathways that have not been previously implicated in regulation of bone metabolism such as OPTN, which was recently found to negatively regulate osteoclast differentiation.