Opt: Inositol 1,4,5-trisphosphate receptor 1

Unique Regulatory Properties of Heterotetrameric Inositol 1,4,5-trisphosphate Receptors Revealed by Studying Concatenated Receptor Constructs.

New

Yule et al., Rochester, United States. In J Biol Chem, Feb 2016

UNASSIGNED: The ability of Inositol 1,4,5-trisphosphate receptors (IP3R) to precisely initiate and generate a diverse variety of intracellular Ca2+ signals is in part mediated by the differential regulation of the three subtypes (R1, R2, R3) by key functional modulators (IP3, Ca2+, ATP).

Endothelial mitochondria regulate the intracellular Ca2+ response to fluid shear stress.

New

Alevriadou et al., United States. In Am J Physiol Cell Physiol, Feb 2016

[Ca(2+)]i transients/oscillations were present when experiments were conducted in Ca(2+)-free solution (plus lanthanum), but absent when ECs were treated with a phospholipase C inhibitor, suggesting that the ER inositol 1,4,5-trisphosphate receptor is responsible for the [Ca(2+)]i response.

Sinomenine potentiates P815 cell degranulation via upregulation of Ca2+ mobilization through the Lyn/PLCγ/IP3R pathway.

New

He et al., Xi'an, China. In Int J Immunopathol Pharmacol, Jan 2016

Furthermore, sinomenine upregulated the phosphorylation of sarcoma (Src), phospholipase C (PLC)-γ1, and IP3 receptor (R).

Modeling analysis of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ mobilization under the control of glucagon-like peptide-1 in mouse pancreatic β-cells.

New

Noma et al., New York City, United States. In Am J Physiol Cell Physiol, Dec 2015

This secretagogue action of GLP-1 is explained, at least in part, by its ability to stimulate cAMP production so that cAMP may facilitate the release of Ca(2+) from IP3 receptor (IP3R)-regulated Ca(2+) stores.

Renal autoregulation in health and disease.

Review

New

Impact

Arendshorst et al., Colombia. In Physiol Rev, Apr 2015

Increased [Ca(2+)]i activates inositol trisphosphate receptors (IP3R) and ryanodine receptors (RyR) to mobilize Ca(2+) from sarcoplasmic reticular stores.

[Role of intracellular Ca2+ dynamics in the development of drug dependence--Participation of Inositol 1,4,5-trisphosphate receptors].

Review

New

Ohkuma et al., In Nihon Arukoru Yakubutsu Igakkai Zasshi, Apr 2015

Our recent studies have reported that the blockade of IP3Rs suppresses the development of rewarding effects on methamphetamine or cocaine, suggesting that functional up-regulation of IP3R-1 occurs during the development of rewarding effects.

Synergistic killing of human small cell lung cancer cells by the Bcl-2-inositol 1,4,5-trisphosphate receptor disruptor BIRD-2 and the BH3-mimetic ABT-263.

Distelhorst et al., Cleveland, United States. In Cell Death Dis, 2014

SCLC cells often overexpress Bcl-2, which protects cells from apoptosis both by sequestering pro-apoptotic family members and by modulating inositol 1,4,5-trisphosphate receptor (IP3R)-mediated calcium signaling.

'Medusa head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 2: Anti-PKC-gamma, anti-GluR-delta2, anti-Ca/ARHGAP26 and anti-VGCC.

Review

Wildemann et al., Heidelberg, Germany. In J Neuroinflammation, 2014

Part 1 focuses on anti-metabotropic glutamate receptor 1-, anti-Homer protein homolog 3-, anti-Sj/inositol 1,4,5-trisphosphate receptor- and anti-carbonic anhydrase-related protein VIII-associated autoimmune cerebellar ataxia (ACA); part 2 covers anti-protein kinase C gamma-, anti-glutamate receptor delta-2-, anti-Ca/RhoGTPase-activating protein 26- and anti-voltage-gated calcium channel-associated ACA; and part 3 reviews the current knowledge on anti-Tr/delta notch-like epidermal growth factor-related receptor-, anti-Nb/AP3B2-, anti-Yo/cerebellar degeneration-related protein 2- and Purkinje cell antibody 2-associated ACA, discusses differential diagnostic aspects, and provides a summary and outlook.

'Medusa-head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII.

Review

Wildemann et al., Heidelberg, Germany. In J Neuroinflammation, 2014

Part 1 focuses on anti-metabotropic glutamate receptor 1-, anti-Homer protein homolog 3-, anti-Sj/inositol 1,4,5-trisphosphate receptor- and anti-carbonic anhydrase-related protein VIII-associated autoimmune cerebellar ataxia (ACA); part 2 covers anti-protein kinase C gamma-, anti-glutamate receptor delta-2-, anti-Ca/RhoGTPase-activating protein 26- and anti-voltage-gated calcium channel-associated ACA; and part 3 reviews the current knowledge on anti-Tr/delta notch-like epidermal growth factor-related receptor-, anti-Nb/AP3B2-, anti-Yo/cerebellar degeneration-related protein 2- and Purkinje cell antibody 2-associated ACA, discusses differential diagnostic aspects and provides a summary and outlook.

Dysfunction of Endoplasmic Reticulum (ER) and Mitochondria (MT) in Alzheimer's Disease: The Role of the ER-MT Cross-Talk.

Review

Penke et al., Szombathely, Hungary. In Curr Alzheimer Res, 2014

Another targets are the UPR cascade proteins (PERK, IRE1, ATF6) and receptors involved in Ca(2+) -level stabilization of the ER (Ryr, IP3R).

'Medusa head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 3: Anti-Yo/CDR2, anti-Nb/AP3B2, PCA-2, anti-Tr/DNER, other antibodies, diagnostic pitfalls, summary and outlook.

Review

Wildemann et al., Heidelberg, Germany. In J Neuroinflammation, 2014

Part 1 focuses on anti-metabotropic glutamate receptor 1-, anti-Homer protein homolog 3-, anti-Sj/inositol 1,4,5-trisphosphate receptor- and anti-carbonic anhydrase-related protein VIII-associated autoimmune cerebellar ataxia (ACA); part 2 covers anti-protein kinase C gamma-, anti-glutamate receptor delta-2-, anti-Ca/RhoGTPase-activating protein 26- and anti-voltage-gated calcium channel-associated ACA; and part 3 reviews the current knowledge on anti-Tr/delta notch-like epidermal growth factor-related receptor-, anti-Nb/AP3B2-, anti-Yo/cerebellar degeneration-related protein 2- and Purkinje cell antibody 2-associated ACA, discusses differential diagnostic aspects and provides a summary and outlook.

The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias.

Impact

Chen et al., Calgary, Canada. In Nat Med, 2014

This newly identified store-sensing gate structure is conserved in all RyR and inositol 1,4,5-trisphosphate receptor isoforms.

Astrocyte-derived ATP modulates depressive-like behaviors.

Impact

Gao et al., Guangzhou, China. In Nat Med, 2013

Both a lack of inositol 1,4,5-trisphosphate receptor type 2 and transgenic blockage of vesicular gliotransmission induced deficiencies in astrocytic ATP release, causing depressive-like behaviors that could be rescued via the administration of ATP.

Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor impairs ER Ca(2+) buffering and causes neurodegeneration in primary cortical neurons.

GeneRIF

Neumar et al., Philadelphia, United States. In J Neurochem, 2012

This study demonstrated that InsP(3)R1 proteolysis disrupts neuronal Ca(2+) homeostasis, and potentially acts as a feed-forward pathway to initiate or execute neuronal death.

Regulation of hair shedding by the type 3 IP3 receptor.

GeneRIF

Mikoshiba et al., Tokyo, Japan. In J Invest Dermatol, 2012

The data suggested that that hair shedding is actively controlled by the IP3R3/NFAT-dependent signaling pathway, possibly through the regulation of cytokeratin filaments in keratinocytes.

Opticin exerts its anti-angiogenic activity by regulating extracellular matrix adhesiveness.

GeneRIF

Bishop et al., Manchester, United Kingdom. In J Biol Chem, 2012

opticin binds to collagen and thereby competitively inhibits endothelial cell interactions with collagen via alpha(1)beta(1) and alpha(2)beta(1) integrins, thereby preventing the strong adhesion that is required for proangiogenic signaling via these integrins.

Temperature-dependent calcium-induced calcium release via InsP3 receptors in mouse olfactory ensheathing glial cells.

GeneRIF

Lohr et al., Kaiserslautern, Germany. In Cell Calcium, 2012

InsP(3) receptors mediate Ca(2+)-induced Ca(2+) release in OECs, and that this Ca(2+) release is temperature-sensitive and can be suppressed at temperatures above 28 degrees C.

Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity.

Impact

Tabas et al., New York City, United States. In Cell Metab, 2012

Here, we show that a calcium-sensing enzyme, CaMKII, is activated in a calcium- and IP3R-dependent manner by cAMP and glucagon in primary hepatocytes and by glucagon and fasting in vivo.

Phase retrieval in protein crystallography.

Impact

Dong et al., Beijing, China. In Acta Crystallogr A, 2012

Opt.

Selective modulation of subtype III IP₃R by Akt regulates ER Ca²⁺ release and apoptosis.

GeneRIF

Pinton et al., Ferrara, Italy. In Cell Death Dis, 2011

The presence of isoform III of inositol 1,4,5-trisphosphate receptor is the key point of Akt activity on calcium-mediated apoptosis.