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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Opsin 3

OPN3, opsin3, Panopsin
Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. In addition to the visual opsins, mammals possess several photoreceptive non-visual opsins that are expressed in extraocular tissues. This gene, opsin 3, is strongly expressed in brain and testis and weakly expressed in liver, placenta, heart, lung, skeletal muscle, kidney, and pancreas. The gene may also be expressed in the retina. The protein has the canonical features of a photoreceptive opsin protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Rhodopsin, p63, CRALBP, V1a, HNP
Papers on OPN3
Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina and cornea.
Van Gelder et al., Seattle, United States. In Proc Natl Acad Sci U S A, Nov 2015
Here, we show that the ex vivo mouse retinal rhythm is most sensitive to short-wavelength light but that this photoentrainment requires neither the short-wavelength-sensitive cone pigment [S-pigment or cone opsin (OPN1SW)] nor encephalopsin (OPN3).
Transcranial light affects plasma monoamine levels and expression of brain encephalopsin in the mouse.
Saarela et al., Oulu, Finland. In J Exp Biol, Jun 2015
Encephalopsin (OPN3) belongs to the light-sensitive transmembrane receptor family mainly expressed in the brain and retina.
Opsin expression in human epidermal skin.
Oancea et al., Providence, United States. In Photochem Photobiol, 2015
Here we show that four opsins—OPN1-SW, OPN2, OPN3 and OPN5—are expressed in the two major human epidermal cell types, melanocytes and keratinocytes, and the mRNA expression profile of these opsins does not change in response to physiological UVR doses.
Expression dynamics and protein localization of rhabdomeric opsins in Platynereis larvae.
Jékely et al., Tübingen, Germany. In Integr Comp Biol, 2013
Here, we identify another Platynereis rhabdomeric opsin, r-opsin3, that is expressed in a single photoreceptor in the eyespots in early trochophores, suggesting that it mediates early larval phototaxis.
The activation of directional stem cell motility by green light-emitting diode irradiation.
Ho et al., Taipei, Taiwan. In Biomaterials, 2013
OFSCs, which are multi-potent mesenchymal stem cells isolated from human orbital fat tissue, constitutionally express three opsins, i.e. retinal pigment epithelium-derived rhodopsin homolog (RRH), encephalopsin (OPN3) and short-wave-sensitive opsin 1 (OPN1SW).
Encephalopsin (OPN3) protein abundance in the adult mouse brain.
Saarela et al., Oulu, Finland. In J Comp Physiol A Neuroethol Sens Neural Behav Physiol, 2012
Encephalopsin belongs to the family of extraretinal opsins having a putative role in CNS tissue photosensitivity.
Opsin3 sensitizes hepatocellular carcinoma cells to 5-fluorouracil treatment by regulating the apoptotic pathway.
Zhu et al., Nanjing, China. In Cancer Lett, 2012
Decreased OPN3 levels in Bel7402(5-FU) cells activated the anti-apoptotic pathway through increasing phospho-Akt and the Bcl2/Bax ratio, while overexpression of OPN3 inactivated this pathway.
Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
Wang et al., Rochester, United States. In Bmc Cancer, 2011
Knockdown of PIP4K2A, CCT5, CMBL, EXO1, KMO and OPN3, genes within 200 kb up-/downstream of the 3 SNPs that were associated with SCLC overall survival (rs1778335, rs2662411 and rs7519667), significantly desensitized H196 to paclitaxel.
The human Müller cell line MIO-M1 expresses opsins.
Kohen et al., Leipzig, Germany. In Mol Vis, 2010
The cells contain mRNA for the following opsins: blue opsin (OPN1SW), rhodopsin (OPN2), panopsin (OPN3), melanopsin (OPN4), neuropsin (OPN5), and peropsin (RRH), as well as for the transducins (guanine nucleotide binding protein [GNAZ], alpha transducing activity polypeptide 1 [GNAT1], alpha transducing activity polypeptide 2 [GNAT2]).
Differential regional expression of genes in the developing brain of Ciona intestinalis embryos.
Hamada et al., Kyoto, Japan. In Zoolog Sci, 2010
For example, Ci-opsin3 and Ci-Dkk3 are expressed in the entire brain, Ci-tyrosinase and Ci-TYRP1 in the dorsal region, and Ci-synaptotagmin3, Ci-ZF399, and Ci-PTFb in the ventral region.
Pathogenesis of allergic airway inflammation.
Shao et al., Omaha, United States. In Curr Allergy Asthma Rep, 2010
Several genes, including ADAM33, DPP10, PHF11, GPRA, TIM-1, PDE4D, OPN3, and ORMDL3, have been implicated in the pathogenesis and susceptibility to atopy and asthma.
Identification of a novel asthma susceptibility gene on chromosome 1qter and its functional evaluation.
Pillai et al., Stevenage, United Kingdom. In Hum Mol Genet, 2008
Polymorphisms in the OPN3 and CHML genes are associated with asthma and atopic asthma.
Origin of the vertebrate visual cycle.
Tsuda et al., Japan. In Photochem Photobiol, 2007
We identified four genes encoding putative visual cycle proteins, homologs of retinal G protein-coupled receptor (Ci-opsin3), cellular retinaldehyde-binding protein (Ci-CRALBP), beta-carotene 15,15'monooxygenase (Ci-BCO) and RPE-specific 65 kDa protein (Ci-RPE65) in the ascidian, Ciona intestinalis.
Origin of the vertebrate visual cycle: III. Distinct distribution of RPE65 and beta-carotene 15,15'-monooxygenase homologues in Ciona intestinalis.
Tsuda et al., Akō, Japan. In Photochem Photobiol, 2006
We previously identified three genes that encode putative visual cycle proteins that are homologues of retinal G-protein coupled receptor (Ci-opsin3), cellular retinaldehyde-binding protein (Ci-CRALBP) and beta-carotene 15,15'-monooxygenase (Ci-BCO) in the ascidian Ciona intestinalis.
Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability.
Tomlinson et al., London, United Kingdom. In Cancer Genet Cytogenet, 2003
Related persons with heterozygous germline deletions of 1q42.3, which includes EXO1, RGS7, KMO, CHML, and OPN3, showed no phenotypic abnormalities other than multiple leiomyomatosis.
Spontaneous activity of opsin apoprotein is a cause of Leber congenital amaurosis.
Lem et al., Los Angeles, United States. In Nat Genet, 2003
studies clearly show that activation of sensory transduction by unliganded opsin, and not the accumulation of retinyl esters, causes light-independent retinal degeneration in Leber congenital amaurosis
Different structural organization of the encephalopsin gene in man and mouse.
Rump et al., Berlin, Germany. In Gene, 2002
Human OPN3 gene consists of six exons and expresses various splice variants.
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