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Opsin 3

OPN3, opsin3, Panopsin
Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. In addition to the visual opsins, mammals possess several photoreceptive non-visual opsins that are expressed in extraocular tissues. This gene, opsin 3, is strongly expressed in brain and testis and weakly expressed in liver, placenta, heart, lung, skeletal muscle, kidney, and pancreas. The gene may also be expressed in the retina. The protein has the canonical features of a photoreceptive opsin protein. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on OPN3
Opsin3 sensitizes hepatocellular carcinoma cells to 5-fluorouracil treatment by regulating the apoptotic pathway.
Zhu et al., Nanjing, China. In Cancer Lett, 2012
Decreased OPN3 levels in Bel7402(5-FU) cells activated the anti-apoptotic pathway through increasing phospho-Akt and the Bcl2/Bax ratio, while overexpression of OPN3 inactivated this pathway.
Identification of a novel asthma susceptibility gene on chromosome 1qter and its functional evaluation.
Pillai et al., Stevenage, United Kingdom. In Hum Mol Genet, 2008
Polymorphisms in the OPN3 and CHML genes are associated with asthma and atopic asthma.
Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability.
Tomlinson et al., London, United Kingdom. In Cancer Genet Cytogenet, 2003
Related persons with heterozygous germline deletions of 1q42.3, which includes EXO1, RGS7, KMO, CHML, and OPN3, showed no phenotypic abnormalities other than multiple leiomyomatosis.
Spontaneous activity of opsin apoprotein is a cause of Leber congenital amaurosis.
Lem et al., Los Angeles, United States. In Nat Genet, 2003
studies clearly show that activation of sensory transduction by unliganded opsin, and not the accumulation of retinyl esters, causes light-independent retinal degeneration in Leber congenital amaurosis
Different structural organization of the encephalopsin gene in man and mouse.
Rump et al., Berlin, Germany. In Gene, 2002
Human OPN3 gene consists of six exons and expresses various splice variants.
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