Open Reading Frame
Role of adenoviruses in obesity.
United States. In Rev Med Virol, Nov 2015
The mechanisms of action of Ad36 are due to the early gene 4, open reading frame 1 (E4-ORF1).
Adenovirus 36 and Obesity: An Overview.
Roma, Italy. In Viruses, Jul 2015
In vivo and in vitro studies have shown that the viral E4orf1 protein (early region 4 open reading frame 1, Adv) mediates the Adv36 effect including its adipogenic potential.
Cell polarity proteins: common targets for tumorigenic human viruses.
Houston, United States. In Oncogene, 2008
For example, adenovirus (Ad) type 9 is unique among human Ads by causing exclusively estrogen-dependent mammary tumors in experimental animals and in having E4 region-encoded open reading frame 1 (E4-ORF1) as its primary oncogenic determinant.