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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Bone morphogenetic protein 8b

OP2, Bmp8b, Bmp8a, BMP-8
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, BMP4, WAVE, AGE, ROD
Papers on OP2
Working "out-of-phase" with reference to chronotype compromises sleep quality in police officers.
Singh et al., Lucknow, India. In Chronobiol Int, Feb 2016
Thereafter, they were allotted their preferred (IP) duty schedule for 4 days, followed by OP2 for further 4 days.
RNA sequencing reveals retinal transcriptome changes in STZ‑induced diabetic rats.
Yang et al., Chengdu, China. In Mol Med Report, Feb 2016
The a‑wave, b‑wave, oscillatory potential 1 (OP1), OP2 and ∑OP amplitudes were significantly reduced in the diabetic group, compared with those of the control group (P<0.05).
Resveratrol Prevents Retinal Dysfunction by Regulating Glutamate Transporters, Glutamine Synthetase Expression and Activity in Diabetic Retina.
Yang et al., Chengdu, China. In Neurochem Res, Jan 2016
RSV administrations also significantly attenuated diabetes-induced decreases in amplitude of a-wave in rod response, decreases in amplitude of a-, and b-wave in cone and rod response and decreases in amplitude of OP2 in oscillatory potentials.
Esophageal Cancer Epigenomics and Integrome Analysis of Genome-Wide Methylation and Expression in High Risk Northeast Indian Population.
Saxena et al., New Delhi, India. In Omics, Nov 2015
These included four genes (PTK2, RND1, RND3, and UBL3) with promoter hypermethylation and downregulation, and 19 genes (SEMG2, CD97, CTNND2, CADM3, OMD, NEFM, FBN2, CTNNB1, DLX6, UGT2B4, CCDC80, PZP, SERPINA4, TNFSF13B, NPC1, COL1A1, TAC3, BMP8A, and IL22RA2) with promoter hypomethylation and upregulation.
Lindley et al., Bangkok, Thailand. In J Pediatr Gastroenterol Nutr, Oct 2015
BACKGROUND: Chronic constipation is one of the most common chronic disease in children.
Xenobiotic-contaminated diets affect hepatic lipid metabolism: Implications for liver steatosis in Sparus aurata juveniles.
Carnevali et al., Ancona, Italy. In Aquat Toxicol, Oct 2015
Lpl mRNA was significantly upregulated in all experimental groups except for BPA1 fish while hsl mRNA was significantly downregulated in all groups except for t-OP2 and BPA1 fish.
The standardized creation of a lumbar spine vertebral compression fracture in a sheep osteoporosis model induced by ovariectomy, corticosteroid therapy and calcium/phosphorus/vitamin D-deficient diet.
Gradl et al., Rostock, Germany. In Injury, Oct 2015
Induction of a VCF of the second lumbar vertebra was performed via a mini-lumbotomy surgical approach with a standardized manual compression mode (OP2).
The brain and brown fat.
López et al., Santiago de Compostela, Spain. In Ann Med, Mar 2015
On the basis of this evidence, extensive research has been focused on BAT function, where new molecules, such as irisin and bone morphogenetic proteins, particularly BMP7 and BMP8B, as well as novel central factors and new regulatory mechanisms, such as orexins and the canonical ventomedial nucleus of the hypothalamus (VMH) AMP- activated protein kinase (AMPK)-SNS-BAT axis, have been discovered and emerged as potential drug targets to combat obesity.
Brown adipose tissue activity as a target for the treatment of obesity/insulin resistance.
Rohner-Jeanrenaud et al., Genève, Switzerland. In Front Physiol, 2014
The mediators of such beneficial effects seem to include FGF21, interleukin-6, BMP8B and prostaglandin D2 synthase.
Brown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity.
Puigserver et al., Boston, United States. In Mol Cell Biol, 2014
In contrast, YY1 represses a series of secreted proteins, including fibroblast growth factor 21 (FGF21), bone morphogenetic protein 8b (BMP8b), growth differentiation factor 15 (GDF15), angiopoietin-like 6 (Angptl6), neuromedin B, and nesfatin, linked to energy expenditure.
Imprinting genes associated with endometriosis.
Kobayashi, Nara, Japan. In Excli J, 2013
From the genomic imprinting database, we picked 10 genes that were highly associated with female reproduction; prominent among them were paternally expressed genes (DIRAS3, BMP8B, CYP1B1, ZFAT, IGF2, MIMT1, or MIR296) and maternally expressed genes (DVL1, FGFRL1, or CDKN1C).
BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions.
Vidal-Puig et al., Cambridge, United Kingdom. In Cell, 2012
Results indicate that BMP8B is a thermogenic protein that regulates energy balance in partnership with hypothalamic AMPK.
[Opisthorchiasis: tradition and innovation].
Grigor'eva, In Eksp Klin Gastroenterol, 2011
Describes the innovations in the diagnosis of opisthorchiasis: primers OP1 and OP2 are used to amplify the ITS2 region rDNK eggs and metacercariae of Opisthorchis in feces.
The protective role of bone morphogenetic protein-8 in the glucocorticoid-induced apoptosis on bone cells.
Lakatos et al., Budapest, Hungary. In Bone, 2011
BMP-8 might be an essential player in bone metabolism, especially in response to glucocorticoids
A signaling principle for the specification of the germ cell lineage in mice.
Saitou et al., Nerima, Japan. In Cell, 2009
Strikingly, Bmp8b from the ExE restricts AVE development, thereby contributing to Bmp4 signaling.
Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas.
Yuasa et al., Tokyo, Japan. In Oncogene, 2006
Epigenetic silencing of the bone morphogenetic protein 2 gene through methylation is associated with gastric carcinomas
Primordial germ cells: what does it take to be alive?
Kierszenbaum et al., New York City, United States. In Mol Reprod Dev, 2004
Secretory bone morphogenetic proteins (BMP) 4, BMP8b, and BMP2 and components of the Smad signaling pathway participate in the specification of PGCs.
The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4.
Kingsley et al., Palo Alto, United States. In Genomics, 1997
Reports on the mouse homolog of this gene.
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