Long-term culture and expansion of primary human hepatocytes.
Jerusalem, Israel. In Nat Biotechnol, Dec 2015
Here we describe the oncostatin M (OSM)-dependent expansion of primary human hepatocytes by low expression of the human papilloma virus (HPV) genes E6 and E7 coupled with inhibition of epithelial-to-mesenchymal transition.
Leukemia inhibitory factor (LIF).
Melbourne, Australia. In Cytokine Growth Factor Rev, Oct 2015
It utilises a receptor that consists of the LIF receptor β and gp130 and this receptor complex is also used by ciliary neurotrophic growth factor (CNTF), oncostatin M, cardiotrophin1 (CT1) and cardiotrophin-like cytokine (CLC).
Rewind to recover: dedifferentiation after cardiac injury.
Philadelphia, United States. In Cell Stem Cell, 2011
In this issue of Cell Stem Cell, Kubin et al. (2011) show that oncostatin M regulates this dedifferentiation which, while beneficial for recovery from acute injury, if persistent results in heart failure in both rodents and humans.