Glycans of myelin proteins.
Stockholm, Sweden. In J Neurosci Res, 2015
The MAG has 10 glycosylation sites; the glycoprotein OMgp has 11 glycosylation sites.
Immunotherapy strategies for spinal cord injury.
Chongqing, China. In Curr Pharm Biotechnol, 2014
In addition, myelinassociated inhibitors (MAIs) in the injured spinal cord, such as Nogo, myelin-associated glycoprotein (MAG) and oligodendrocyte- myelin glycoprotein (OMgp) are known to prevent axonal regeneration through their co-receptors, and to trigger demyelinating autoimmunity through T cell-mediated harmful autoimmune response.
Insights into the physiological role of CNS regeneration inhibitors.
Ann Arbor, United States. In Front Mol Neurosci, 2014
Prototypic CNS regeneration inhibitors are broadly expressed in the healthy and injured brain and spinal cord and include myelin-associated glycoprotein (MAG), the reticulon family member NogoA, oligodendrocyte myelin glycoprotein (OMgp), and chondroitin sulfate proteoglycans (CSPGs).
α-Fluorophosphonates reveal how a phosphomutase conserves transition state conformation over hexose recognition in its two-step reaction.
Sheffield, United Kingdom. In Proc Natl Acad Sci U S A, 2014
Its equatorial hydroxyl groups are hydrogen-bonded directly to the enzyme rather than indirectly via water molecules as in step 2. The (C)O-P bond orientation for binding the phosphate in the inert phosphate site differs by ∼ 30° between steps 1 and 2. By contrast, the orientations for the axial O-Mg-O alignment for the TSA of the phosphoryl group in the catalytic site differ by only ∼ 5°, and the atoms representing the five phosphorus-bonded oxygens in the two transition states (TSs) are virtually superimposable.