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Oligodendrocyte transcription factor 2

Olig2
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Olig1, Glial Fibrillary Acidic Protein, FATE, Phosphoglucomutase
Papers using Olig2 antibodies
2′, 3′-cyclic nucleotide 3′-phosphodiesterase, an oligodendrocyte-Schwann cell and myelin-associated enzyme of the nervous system.
Supplier
Reh Thomas A., In PLoS ONE, 1988
... Briefly, Olig2 cDNA was ligated into multiple cloning sites of the retroviral vector pLHCX (Clontech, Mountain View, CA) ...
Papers on Olig2
Generation and isolation of oligodendrocyte progenitor cells from human pluripotent stem cells.
New
Fossati et al., New York City, United States. In Nat Protoc, 31 Aug 2015
Within 8 d, PSCs differentiate into paired box 6-positive (PAX6(+)) neural stem cells, which give rise to OLIG2(+) progenitors by day 12. Oligodendrocyte lineage transcription factor 2-positive (OLIG2(+)) cells begin to express the transcription factor NKX2.2 around day 18, followed by SRY-box 10 (SOX10) around day 40.
Effect of postnatal progesterone therapy following preterm birth on neurosteroid concentrations and cerebellar myelination in guinea pigs.
New
Hirst et al., Newcastle, Australia. In J Dev Orig Health Dis, 31 Aug 2015
Brain and plasma allopregnanolone concentrations were measured by radioimmunoassay; cortisol and progesterone concentrations were determined by enzyme immunoassay; and myelin basic protein (MBP), proteolipid protein (PLP), oligodendroctye transcription factor 2 (OLIG2) and platelet-derived growth factor receptor-α (PDGFRα) were quantified by immunohistochemistry and western blot.
Expression of the miR-302/367 cluster in glioblastoma cells suppresses tumorigenic gene expression patterns and abolishes transformation related phenotypes.
New
Groner et al., Frankfurt am Main, Germany. In Int J Cancer, 20 Jun 2015
Induction of the miR-302/367 cluster in extensively mutated U87MG glioblastoma cells drastically suppressed the expression of transformation related proteins, e.g. the reprogramming factors OCT3/4, SOX2, KLF4 and c-MYC, and the transcription factors POU3F2, SALL2 and OLIG2, required for the maintenance of glioblastoma stem like tumor propagating cells.
Disruption of neurogenesis and cortical development in transgenic mice misexpressing Olig2, a gene in the Down syndrome critical region.
New
Richard Lu et al., Chengdu, China. In Neurobiol Dis, May 2015
The basic helix-loop-helix (bHLH) transcription factor Olig2 is crucial for mammalian central nervous system development.
Direct conversion of human fibroblasts into dopaminergic neural progenitor-like cells using TAT-mediated protein transduction of recombinant factors.
New
Baharvand et al., Tehrān, Iran. In Biochem Biophys Res Commun, May 2015
The generated iDPCs expressed various NPC markers (SOX2, PAX6, NESTIN, OLIG2) and midbrain progenitor markers (EN1, LMX1a, FOXA2, WNT1) as detected by immunostaining and real-time PCR.
Disseminated oligodendroglial cell-like leptomeningeal tumors: preliminary diagnostic and therapeutic results for a novel tumor entity.
New
Kuchelmeister et al., Leipzig, Germany. In J Neurooncol, Mar 2015
The oligoid cells in a desmoplastic or focally myxoid matrix showed OLIG2-, MAP2-, S-100 and rare HuC/HuD protein-immunopositivity.
Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells.
New
Impact
Bernstein et al., United States. In Cell, May 2014
Here, we identify a core set of neurodevelopmental TFs (POU3F2, SOX2, SALL2, and OLIG2) essential for GBM propagation.
Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination.
Impact
Goldman et al., Rochester, United States. In Cell Stem Cell, 2013
From three hiPSC lines, as well as from human embryonic stem cells (hESCs), we generated highly enriched OLIG2(+)/PDGFRα(+)/NKX2.2(+)/SOX10(+) human OPCs, which could be further purified using fluorescence-activated cell sorting.
Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2.
Review
Impact
Rowitch et al., Boston, United States. In Nat Rev Neurosci, 2012
The basic helix-loop-helix transcription factors oligodendrocyte transcription factor 1 (OLIG1) and OLIG2 are structurally similar and, to a first approximation, coordinately expressed in the developing CNS and postnatal brain.
Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.
Impact
Pfister et al., Heidelberg, Germany. In Cancer Cell, 2012
We also demonstrate that the two H3F3A mutations give rise to GBMs in separate anatomic compartments, with differential regulation of transcription factors OLIG1, OLIG2, and FOXG1, possibly reflecting different cellular origins.
Antagonistic modulation of gliomagenesis by Pax6 and Olig2 in PDGF-induced oligodendroglioma.
GeneRIF
Malatesta et al., Genova, Italy. In Int J Cancer, 2012
Olig2 is strictly required to maintain the malignancy of oligodendroglioma cells.
[A flow cytometric postmortem brain study for major depressive disorders: implication for oligodendroglial differentiation and functions].
Review
Tatebayashi et al., Tokyo, Japan. In Nihon Shinkei Seishin Yakurigaku Zasshi, 2012
Anisotropic frozen brain tissue was transformed into an isotropic suspension of nuclei; the numbers and fluorescent intensities of 7-AAD(+), a DNA marker, were quantified; and the nuclei were immunolabeled for the neuronal and oligodendroglial nuclear markers, NeuN and olig2, respectively.
Markers of survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative genomic analysis.
Impact
Huang et al., Toronto, Canada. In Lancet Oncol, 2012
FINDINGS: We identified three molecular subgroups of CNS PNETs that were distinguished by primitive neural (group 1), oligoneural (group 2), and mesenchymal lineage (group 3) gene-expression signatures with differential expression of cell-lineage markers LIN28 and OLIG2.
Olig2-dependent developmental fate switch of NG2 cells.
GeneRIF
Nishiyama et al., United States. In Development, 2012
The findings indicated that NG2+ polydendrocytes in the embryonic and early postnatal brain exhibit developmental fate switch from oligodendrocytes to astrocytes in vivo upon removal of Olig2.
OLIG2 over-expression impairs proliferation of human Down syndrome neural progenitors.
GeneRIF
Sheen et al., Boston, United States. In Hum Mol Genet, 2012
OLIG2 over-expression inhibits neural progenitor proliferation through changes in potassium channel activity, thereby contributing to the reduced neuronal numbers and brain size in DS.
Modification of pax6 and olig2 expression in adult hippocampal neurogenesis selectively induces stem cell fate and alters both neuronal and glial populations.
GeneRIF
Peterson et al., North Chicago, United States. In Stem Cells, 2012
Pax6 decreases the number of Neuron-Glia 2 progenitor cells and prevents oligodendrocytic lineage commitment, while repression of Olig2 results in an expanded astrocytic lineage.
olig2-Expressing hindbrain cells are required for migrating facial motor neurons.
GeneRIF
Appel et al., Aurora, United States. In Dev Dyn, 2012
these data raise the possibility that cells expressing olig2 are intermediate targets that help guide facial motor neuron migration.
Behavior of neural stem cells in the Alzheimer brain.
Review
Shetty et al., Durham, United States. In Cell Mol Life Sci, 2008
Furthermore, fibrillary Abeta and down-regulation of oligodendrocyte-lineage transcription factor-2 (OLIG2) may cause the death of these nonfunctional neurons.
The evolution of Olig genes and their roles in myelination.
Review
Richardson et al., London, United Kingdom. In Neuron Glia Biol, 2008
The transcription factors OLIG1 and OLIG2, master regulators of OL development, presumably also played a seminal role during the evolution of the genetic programme leading to myelination in the CNS.
Cell fate determination regulated by a transcriptional signal network in the developing mouse brain.
Review
Taga et al., Kumamoto, Japan. In Anat Sci Int, 2005
For instance, in fetal brain, it has been shown that the neurogenic transcription factor Neurogenin1 inhibits formation of a STAT3/p300/ Smad1 complex and that the oligodendrocytic transcription factor OLIG2 does the same.
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