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Oligodendrocyte transcription factor 2

Olig2
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Olig1, FATE, Glial Fibrillary Acidic Protein, ACID
Papers using Olig2 antibodies
2′, 3′-cyclic nucleotide 3′-phosphodiesterase, an oligodendrocyte-Schwann cell and myelin-associated enzyme of the nervous system.
Supplier
Reh Thomas A., In PLoS ONE, 1988
... Briefly, Olig2 cDNA was ligated into multiple cloning sites of the retroviral vector pLHCX (Clontech, Mountain View, CA) ...
Papers on Olig2
Human Adult White Matter Progenitor Cells Are Multipotent Neuroprogenitors Similar to Adult Hippocampal Progenitors.
New
Storch et al., Dresden, Germany. In Stem Cells Transl Med, 20 Mar 2014
Freshly isolated cells from subcortical white matter and hippocampus expressed oligodendrocyte progenitor cell markers such as A2B5, neuron-glial antigen 2 (NG2), and oligodendrocyte transcription factor 2 (OLIG2) in ∼20% of cells but no neural stem cell (NSC) markers such as CD133 (Prominin1), Nestin, SOX2, or PAX6.
Distinct neural stem cell tropism, early immune activation, and choroid plexus pathology following coxsackievirus infection in the neonatal central nervous system.
New
Feuer et al., San Diego, United States. In Lab Invest, 28 Feb 2014
LCMV infected a greater number of cells in the SVZ and targeted both nestin(+) (neural progenitor cell marker) and olig2(+) (glial progenitor marker) cells at a relatively equal proportion.
Subtyping of gliomas of various WHO grades by the application of immunohistochemistry.
New
Alafuzoff et al., Uppsala, Sweden. In Histopathology, 28 Feb 2014
High expression levels of epidermal growth factor receptor (EGFR), CD44, c-MER proto-oncogene tyrosine kinase (MERTK), platelet-derived growth factor receptor α, p53, oligodendrocyte transcription factor 2 (OLIG2) and isocitrate dehydrogenase 1 with the R132H mutation were assessed using immunohistochemistry (IHC).
Global identification of genes targeted by DNMT3b for epigenetic silencing in lung cancer.
New
Belinsky et al., Albuquerque, United States. In Oncogene, 27 Feb 2014
Two genes studied in detail, MAL and OLIG2, were silenced during transformation, initially through enrichment for H3K27me3 and H3K9me2, commonly methylated in lung cancer, and exert tumor suppressor effects in vivo through modulating cancer-related pathways.
Exhaustive Exercise Modifies Different Gene Expression Profiles and Pathways in LPS-stimulated and Un-stimulated Whole Blood Cultures.
New
Northoff et al., Tübingen, Germany. In Brain Behav Immun, Nov 2013
Exercise also significantly changed the expression of genes (OLIG2, TMEM106B) which are known to be related to brain function and expression of which has never been documented in peripheral blood.
Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination.
New
Impact
Goldman et al., Rochester, United States. In Cell Stem Cell, Mar 2013
From three hiPSC lines, as well as from human embryonic stem cells (hESCs), we generated highly enriched OLIG2(+)/PDGFRα(+)/NKX2.2(+)/SOX10(+) human OPCs, which could be further purified using fluorescence-activated cell sorting.
High yields of oligodendrocyte lineage cells from human embryonic stem cells at physiological oxygen tensions for evaluation of translational biology.
Franklin et al., Cambridge, United Kingdom. In Stem Cell Reports, 2012
Developmental insights reveal a critical role for fibroblast growth factor 2 (FGF-2) in OLIG2 induction via ventral forebrain pathways.
Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2.
Review
Impact
Rowitch et al., Boston, United States. In Nat Rev Neurosci, 2012
The basic helix-loop-helix transcription factors oligodendrocyte transcription factor 1 (OLIG1) and OLIG2 are structurally similar and, to a first approximation, coordinately expressed in the developing CNS and postnatal brain.
Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.
Impact
Pfister et al., Heidelberg, Germany. In Cancer Cell, 2012
We also demonstrate that the two H3F3A mutations give rise to GBMs in separate anatomic compartments, with differential regulation of transcription factors OLIG1, OLIG2, and FOXG1, possibly reflecting different cellular origins.
Antagonistic modulation of gliomagenesis by Pax6 and Olig2 in PDGF-induced oligodendroglioma.
GeneRIF
Malatesta et al., Genova, Italy. In Int J Cancer, 2012
Olig2 is strictly required to maintain the malignancy of oligodendroglioma cells.
Markers of survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative genomic analysis.
Impact
Huang et al., Toronto, Canada. In Lancet Oncol, 2012
FINDINGS: We identified three molecular subgroups of CNS PNETs that were distinguished by primitive neural (group 1), oligoneural (group 2), and mesenchymal lineage (group 3) gene-expression signatures with differential expression of cell-lineage markers LIN28 and OLIG2.
[A flow cytometric postmortem brain study for major depressive disorders: implication for oligodendroglial differentiation and functions].
Review
Tatebayashi et al., Tokyo, Japan. In Nihon Shinkei Seishin Yakurigaku Zasshi, 2012
Anisotropic frozen brain tissue was transformed into an isotropic suspension of nuclei; the numbers and fluorescent intensities of 7-AAD(+), a DNA marker, were quantified; and the nuclei were immunolabeled for the neuronal and oligodendroglial nuclear markers, NeuN and olig2, respectively.
Olig2-dependent developmental fate switch of NG2 cells.
GeneRIF
Nishiyama et al., United States. In Development, 2012
The findings indicated that NG2+ polydendrocytes in the embryonic and early postnatal brain exhibit developmental fate switch from oligodendrocytes to astrocytes in vivo upon removal of Olig2.
OLIG2 over-expression impairs proliferation of human Down syndrome neural progenitors.
GeneRIF
Sheen et al., Boston, United States. In Hum Mol Genet, 2012
OLIG2 over-expression inhibits neural progenitor proliferation through changes in potassium channel activity, thereby contributing to the reduced neuronal numbers and brain size in DS.
Modification of pax6 and olig2 expression in adult hippocampal neurogenesis selectively induces stem cell fate and alters both neuronal and glial populations.
GeneRIF
Peterson et al., North Chicago, United States. In Stem Cells, 2012
Pax6 decreases the number of Neuron-Glia 2 progenitor cells and prevents oligodendrocytic lineage commitment, while repression of Olig2 results in an expanded astrocytic lineage.
olig2-Expressing hindbrain cells are required for migrating facial motor neurons.
GeneRIF
Appel et al., Aurora, United States. In Dev Dyn, 2012
these data raise the possibility that cells expressing olig2 are intermediate targets that help guide facial motor neuron migration.
Behavior of neural stem cells in the Alzheimer brain.
Review
Shetty et al., Durham, United States. In Cell Mol Life Sci, 2008
Furthermore, fibrillary Abeta and down-regulation of oligodendrocyte-lineage transcription factor-2 (OLIG2) may cause the death of these nonfunctional neurons.
The evolution of Olig genes and their roles in myelination.
Review
Richardson et al., London, United Kingdom. In Neuron Glia Biol, 2008
The transcription factors OLIG1 and OLIG2, master regulators of OL development, presumably also played a seminal role during the evolution of the genetic programme leading to myelination in the CNS.
Cell fate determination regulated by a transcriptional signal network in the developing mouse brain.
Review
Taga et al., Kumamoto, Japan. In Anat Sci Int, 2005
For instance, in fetal brain, it has been shown that the neurogenic transcription factor Neurogenin1 inhibits formation of a STAT3/p300/ Smad1 complex and that the oligodendrocytic transcription factor OLIG2 does the same.
Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia.
Impact
Look et al., Boston, United States. In Lancet, 2004
We investigated the prognostic effect of the expression levels of eight oncogenic transcription factors--TLX1 (HOX11), TLX3 (HOX11L2), TAL1, TAL2, LYL1, OLIG2 (BHLHB1), LMO1, and LMO2--in 52 adults with T-cell acute lymphoblastic leukaemia.
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