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Olfactory receptor 154

OLFR43, OR912-93, mOR912-93
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: OUT, ACID, SET, OLF, CAN
Papers on OLFR43
Differences in (-)citronellal binding to various odorant receptors.
Buchbauer et al., Vienna, Austria. In Biochem Biophys Res Commun, 2007
Structurally similar receptors provide identical binding pockets (OLFR43, OR1A1, and OR1A2), and have comparable EC(50) values.
Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2.
Krautwurst et al., Potsdam, Germany. In J Struct Biol, 2007
We found that (i) their odorant profiles are centred around citronellic terpenoid structures, (ii) two evolutionary conserved amino acid residues in transmembrane domain 3 are necessary for the responsiveness of OR1A1 and the mouse ortholog Olfr43 to (S)-(-)-citronellol, (iii) changes at these two positions are sufficient to account for the differential (S)-(-)-citronellol responsiveness of the paralogs OR1A1 and OR1A2, and (iv) the interaction sites for (S)-(-)-citronellal and (S)-(-)-citronellol differ in both human receptors.
Identification of specific ligands for orphan olfactory receptors. G protein-dependent agonism and antagonism of odorants.
Krautwurst et al., Potsdam, Germany. In J Biol Chem, 2005
To demonstrate the G protein dependence of its odorant response pattern, we screened the most sensitive (-)citronellal receptor Olfr43 versus 94 odorants simultaneously in the presence of Galpha15 or Galphaolf.
Test of the Binding Threshold Hypothesis for olfactory receptors: explanation of the differential binding of ketones to the mouse and human orthologs of olfactory receptor 912-93.
Goddard et al., Pasadena, United States. In Protein Sci, 2005
To investigate the origins of this difference, we used the MembStruk first-principles method to predict the tertiary structure of the mouse OR 912-93 (mOR912-93), and the HierDock first-principles method to predict the binding site for ketones to this receptor.
Amino-acid changes acquired during evolution by olfactory receptor 912-93 modify the specificity of odorant recognition.
Giorgi et al., Rouen, France. In Hum Mol Genet, 2004
We previously identified the structural motifs of odorant molecules (aliphatic 2- or 3-ketones) required to activate mouse OR912-93 by detection of the odorant response using calcium measurement in transfected cells.
A single olfactory receptor specifically binds a set of odorant molecules.
Giorgi et al., Montpellier, France. In Eur J Neurosci, 2002
In the present work, we identified the structural motifs of odorant molecules required to activate mouse OR912-93 by detection of the odorant response using calcium measurement in cells transfected with OR and G(alpha)q and G(alpha)15 proteins.
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