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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

G protein-coupled receptor 68

OGR1, ovarian cancer G protein-coupled receptor 1, GPR68
Top mentioned proteins: GPR4, ACID, TDAG8, G2A, CAN
Papers on OGR1
Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.
New
Impact
Roth et al., Chapel Hill, United States. In Nature, Dec 2015
Among these is GPR68, a proton receptor that lacks small molecule modulators for probing its biology.
The pH-sensing receptor OGR1 improves barrier function of epithelial cells and inhibits migration in an acidic environment.
New
Seuwen et al., Zürich, Switzerland. In Am J Physiol Gastrointest Liver Physiol, Oct 2015
The pH-sensing receptor ovarian cancer G protein-coupled receptor 1 (OGR1; GPR68) is expressed in the gut.
Reciprocal regulation of two G protein-coupled receptors sensing extracellular concentrations of Ca2+ and H.
New
Glitsch et al., Oxford, United Kingdom. In Proc Natl Acad Sci U S A, Sep 2015
Extracellular calcium-sensing receptor (CaSR) and ovarian cancer gene receptor 1 (OGR1) are two GPCRs that sense extracellular Ca(2+) and H(+), respectively.
Increased expression of the proton-sensing G protein-coupled receptor Gpr65 during retinal degeneration.
New
Grimm et al., Zürich, Switzerland. In Neuroscience, Sep 2015
GPR4, GPR65 and GPR68 are G protein-coupled receptors that aid cells to sense and survive conditions of acidic pH and inflammatory cells express Gpr65 enhancing their viability.
In Vitro Fluorogenic Real-Time Assay of the Repair of Oxidative DNA Damage.
New
Kool et al., Stanford, United States. In Chembiochem, Aug 2015
We tested 42 potential probes containing these fluorophores: the optimum probe, OGR1, yields a 60-fold light-up signal in vitro with OGG1 and Fpg.
Characterization of Imidazopyridine Compounds as Negative Allosteric Modulators of Proton-Sensing GPR4 in Extracellular Acidification-Induced Responses.
Okajima et al., Maebashi, Japan. In Plos One, 2014
In the cells that express proton-sensing GPCRs, including GPR4, OGR1, TDAG8, and G2A, extracellular acidification stimulates serum responsive element (SRE)-driven transcriptional activity, which has been shown to reflect Rho activity, with different proton sensitivities.
Identification of metals from osteoblastic ST-2 cell supernatants as novel OGR1 agonists.
Nara et al., Tokyo, Japan. In J Recept Signal Transduct Res, 2014
Ovarian cancer G-protein-coupled receptor 1 (OGR1) is a G-protein-coupled receptor (GPCR), which has previously been identified as a receptor for protons.
Constitutive Activity among Orphan Class-A G Protein Coupled Receptors.
Aronstam et al., Rolla, United States. In Plos One, 2014
Five patterns of activity were noted: 1) inhibition under both baseline and forskolin stimulated expression (GPR15, GPR17, GPR18, GPR20, GPR25, GPR27, GPR31, GPR32, GPR45, GPR57, GPR68, GPR83, GPR84, GPR132, GPR150, GPR176); 2) no effect on baseline expression, but inhibition of forskolin stimulated expression (GPR4, GPR26, GPR61, GPR62, GPR78, GPR101, GPR119); 3) elevation of baseline signaling coupled with inhibition of forskolin stimulated expression (GPR6, GPR12); 4) elevation of baseline signaling without inhibition of forskolin stimulated expression (GPR3, GPR21, GPR52, GPR65); and 5) no effect on expression (GPR1, GPR19, GPR22, GPR34, GPR35, GPR39, GPR63, GPR82, GPR85, GPR87).
Ionotropic and metabotropic proton-sensing receptors involved in airway inflammation in allergic asthma.
Review
Okajima et al., Maebashi, Japan. In Mediators Inflamm, 2013
Recent studies have revealed that ovarian cancer G protein-coupled receptor 1 (OGR1)-family G protein-coupled receptors, which sense pH of more than 6.0, are expressed in structural cells, such as airway smooth muscle cells and epithelial cells, and in inflammatory and immune cells, such as eosinophils and dendritic cells.
Role of extracellular proton-sensing OGR1 in regulation of insulin secretion and pancreatic β-cell functions.
Review
Okajima et al., Maebashi, Japan. In Endocr J, 2013
Studies with receptor knockout mice have revealed that proton-sensing receptors, including ovarian cancer G protein-coupled receptor 1 (OGR1), a proton-sensing GPCRs, play a role in the regulation of insulin secretion and glucose metabolism under physiological conditions.
Molecular actions of ovarian cancer G protein-coupled receptor 1 caused by extracellular acidification in bone.
Review
Dong et al., Shanghai, China. In Int J Mol Sci, 2013
In recent years there has been increasing evidence which indicates that ovarian cancer G protein-coupled receptor 1 (OGR1) is a pH-sensing receptor and mediates a variety of extracellular acidification-induced actions on bone cells and other cell types.
pH sensing and regulation in cancer.
Review
Gillies et al., Tampa, United States. In Front Physiol, 2012
However, there is evidence that expression of proton-sensing GPCRs such as GPR4, TDAG8, and OGR1 can regulate aspects of tumorigenesis and invasion, including cofilin and talin regulated actin (de-)polymerization.
Acidic tumor microenvironment and pH-sensing G protein-coupled receptors.
Review
Yang et al., Greenville, United States. In Front Physiol, 2012
Recent studies show that the pH-sensing GPCRs, including GPR4, GPR65 (TDAG8), GPR68 (OGR1), and GPR132 (G2A), regulate cancer cell metastasis and proliferation, immune cell function, inflammation, and blood vessel formation.
Deficiency of proton-sensing ovarian cancer G protein-coupled receptor 1 attenuates glucose-stimulated insulin secretion.
GeneRIF
Okajima et al., Maebashi, Japan. In Endocrinology, 2012
Deficiency of proton-sensing ovarian cancer G protein-coupled receptor 1 attenuates glucose-stimulated insulin secretion.
The proton-activated G protein coupled receptor OGR1 acutely regulates the activity of epithelial proton transport proteins.
GeneRIF
Wagner et al., Zürich, Switzerland. In Cell Physiol Biochem, 2011
OGR1 alters the pH-sensitive response of NHE and H+-ATPase activity in proximal tubules.
Extracellular acidification induces connective tissue growth factor production through proton-sensing receptor OGR1 in human airway smooth muscle cells.
GeneRIF
Okajima et al., Maebashi, Japan. In Biochem Biophys Res Commun, 2011
extracellular acidification induces CTGF production through the OGR1/G(q/11) protein and inositol-1,4,5-trisphosphate-induced Ca(2+) mobilization in human airway smooth muscle cells.
Effects of ovarian cancer G protein coupled receptor 1 on the proliferation, migration, and adhesion of human ovarian cancer cells.
GeneRIF
Zhang et al., Xi'an, China. In Chin Med J (engl), 2011
It indicated that OGR1 may be a tumor suppressor gene for ovarian cancer.
Ovarian cancer G protein-coupled receptor 1-dependent and -independent vascular actions to acidic pH in human aortic smooth muscle cells.
GeneRIF
Okajima et al., Maebashi, Japan. In Am J Physiol Heart Circ Physiol, 2010
acidic pH-induced vascular actions of aortic smooth muscle cells can be dissected to OGR1-dependent and -independent pathways: COX-2 expression, PGI(2) production, and MKP-1 expression are mediated by OGR1, but PAI-1 expression is not.
Proton-sensing G-protein-coupled receptors.
Impact
GeneRIF
Seuwen et al., Basel, Switzerland. In Nature, 2003
ovarian cancer G-protein-coupled receptor 1 (OGR1), previously described as a receptor for sphingosylphosphorylcholine, acts as a proton-sensing receptor stimulating inositol phosphate formation
Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1.
Impact
Damron et al., Cleveland, United States. In Nat Cell Biol, 2000
Here we show that SPC is a high-affinity ligand for an orphan receptor, ovarian cancer G-protein-coupled receptor 1 (OGR1).
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