Current concept of photocarcinogenesis.
Kōbe, Japan. In Photochem Photobiol Sci, Oct 2015
It has been shown that in Ogg1 knockout mice which are deficient in repairing 8-oxo-7, 8-dihydroguanine (8-oxoG), UVB irradiation up-regulates the inflammatory gene, implying that 8-oxoG is involved in triggering inflammation.
Molecular basis of asbestos-induced lung disease.
China. In Annu Rev Pathol, 2013
We review mitochondrial DNA (mtDNA)-damage and -repair mechanisms, focusing on 8-oxoguanine DNA glycosylase, as well as cross talk between reactive oxygen species production, mtDNA damage, p53, OGG1, and mitochondrial aconitase.
OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells.
Rochester, United States. In Nature, 2007
Here we show that the age-dependent somatic mutation associated with Huntington's disease occurs in the process of removing oxidized base lesions, and is remarkably dependent on a single base excision repair enzyme, 7,8-dihydro-8-oxoguanine-DNA glycosylase (OGG1).