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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Plexin A2

OCT
This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, AGE, Oct-1, V1a
Papers using OCT antibodies
Current sunscreen issues: 2007 Food and Drug Administration sunscreen labelling recommendations and combination sunscreen/insect repellent products
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Meghea Aurelia et al., In Nanoscale Research Letters, 2007
... -α-Phosphatidylcholine (Lecithin), OCT, 97% and OMC, 98% were obtained from Sigma Aldrich Chemie GmbH (Munich, Germany); ...
Food-associated cues alter forebrain functional connectivity as assessed with immediate early gene and proenkephalin expression.
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Wong Rachel, In PLoS ONE, 2006
... For tissue punches of specific regions, brains were embedded in OCT media and sectioned on a Leica (CM3050) cryostat at −25°C ...
Antigen-retrieval procedure for bromodeoxyuridine immunolabeling with concurrent labeling of nuclear DNA and antigens damaged by HCl pretreatment.
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Androutsellis-Theotokis Andreas, In PLoS ONE, 2006
... After cryoprotection in 30% sucrose, 22X40X20 mm blocks were embedded in Tissue-TEK OCT compound, frozen, and sectioned at 20 microns.Antigen retrieval was done in 1X Antigen retrieval citra buffer (Biogenex) in a microwave at 40% ...
Preparation and Characterization of a Lecithin Nanoemulsion as a Topical Delivery System
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Duan Mingxing et al., In Nanoscale Research Letters, 2003
... 2-Propanol and optimal cutting temperature compound (OCT) were purchased from Leica microsystem, German ...
Myosin-X provides a motor-based link between integrins and the cytoskeleton
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Tyska Matthew J. et al., In The Journal of Cell Biology, 2003
... Tissue was embedded in OCT, frozen, and 20-µm-thick transverse sections were cut on a cryostat (Leica).
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Papers on OCT
The Natural History of the Progression of Atrophy Secondary to Stargardt Disease (ProgStar) Studies: Design and Baseline Characteristics: ProgStar Report No. 1.
New
Progression of Stargardt Disease Study Group et al., London, United Kingdom. In Ophthalmology, Feb 2016
METHODS: In the retrospective study, patients contributed medical record data from at least 2 and up to 4 visits for at least 1 examination modality: fundus autofluorescence (FAF), spectral-domain (SD) optical coherence tomography (SD OCT), and/or microperimetry (MP).
Fundus Autofluorescence and SD-OCT Document Rapid Progression in Autosomal Dominant Vitreoretinochoroidopathy (ADVIRC) Associated with a c.256G > A Mutation in BEST1.
New
Weber et al., Siegburg, Germany. In Ophthalmic Genet, Feb 2016
METHODS: Three affected members of a four-generation ADVIRC family were examined with fundus autofluorescence (FAF), near-infrared autofluorescence (NIA) and spectral domain optical coherence tomography (SD-OCT).
Overexpression of SDF-1 activates the NF-κB pathway to induce epithelial to mesenchymal transition and cancer stem cell-like phenotypes of breast cancer cells.
New
Li et al., Mudanjiang, China. In Int J Oncol, Feb 2016
accompanied by the apparently elevated ALDH activity and the upregulation of the stem cell markers OCT-4, Nanog, and SOX2 compared with parental (P<0.01).
Photodynamic therapy in VEGF inhibition non-responders-pharmacogenetic study in age-related macular degeneration assessed with swept-source optical coherence tomography.
New
Wylegala et al., Katowice, Poland. In Photodiagnosis Photodyn Ther, Feb 2016
Swept-source optical coherence tomography (SS-OCT) gives exceptional insight into the retina and choroid.
A PET Tracer For Renal Organic Cation Transporters, 11C-metformin: Radiosynthesis and Preclinical Proof-of-Concept Studies.
New
Frøkiær et al., Århus, Denmark. In J Nucl Med, Feb 2016
UNASSIGNED: Organic cation transporters (OCT) in the kidney proximal tubule (PT) participate in renal excretion of drugs and endogenous compounds.
Ocular Toxicity in Metastatic Melanoma Patients Treated With Mitogen-Activated Protein Kinase Kinase Inhibitors: A Case Series.
Review
New
Guida et al., Bari, Italy. In Am J Ophthalmol, Nov 2015
When pathologic findings were found, patients underwent visual field examination, optical coherence tomography (OCT), and/or fluorescein angiography.
Pharmacogenetics and individual responses to treatment of hyperglycemia in type 2 diabetes.
Review
New
Vestergaard et al., Copenhagen, Denmark. In Pharmacogenet Genomics, Oct 2015
Some are present in drug receptors or drug metabolizers (OCT genes, KCNJ11, ABCC8, and CYP2C9).
Mouse Models of Experimental Autoimmune Uveitis: Comparative Analysis of Adjuvant-Induced vs Spontaneous Models of Uveitis.
Review
Caspi et al., Guangzhou, China. In Curr Mol Med, 2014
This review will discuss and compare clinical manifestations, pathology as well as visual function of the retina in the different models of uveitis, as measured by fundus imaging and histology, optical coherence tomography (OCT) and electroretinography (ERG).
Role of transporters in the distribution of platinum-based drugs.
Review
Ciarimboli et al., Münster, Germany. In Front Pharmacol, 2014
The copper transporter 1 seems to be of particular importance for cisplatin uptake in tumor cells, while the organic cation transporter (OCT) 2, due to its specific organ distribution, may play a major role in the development of undesired cisplatin side effects.
Treatment as Required versus Regular Monthly Treatment in the Management of Neovascular Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis.
Review
Ehlken et al., Freiburg, Germany. In Plos One, 2014
Overall, the results indicate that an individualized treatment approach with anti-VEGF using visual acuity and OCT-guided re-treatment criteria may be appropriate for most patients with nAMD.
PlexinA2 mediates osteoblast differentiation via regulation of Runx2.
GeneRIF
Kim et al., Seoul, South Korea. In J Bone Miner Res, 2012
results of our study reveal that PlxnA2 has a pro-osteogenic function by modulating BMP2 signaling
Semaphorin-plexin signalling genes associated with human breast tumourigenesis.
GeneRIF
Griffiths et al., Gold Coast, Australia. In Gene, 2012
in vitro analysis of PLXNA2 revealed that the gene has higher expression in more aggressive breast cancer cell types.
Randomized trial of tamoxifen versus combined tamoxifen and octreotide LAR Therapy in the adjuvant treatment of early-stage breast cancer in postmenopausal women: NCIC CTG MA.14.
Impact
Pollak et al., Toronto, Canada. In J Clin Oncol, 2011
PATIENTS AND METHODS: The NCIC CTG MA.14 (NCIC Clinical Trials Group MA.14) trial randomly assigned postmenopausal women to 5 years of tamoxifen 20 mg daily (TAM) or TAM plus 2 years of octreotide 90 mg depot intramuscular injections monthly (TAM-OCT) as adjuvant therapy.
Identification of the semaphorin receptor plexin-A2 as a candidate gene for susceptibility to ankylosing spondylitis.
GeneRIF
Drosos et al., In Clin Exp Rheumatol, 2011
PLXNA2 polymorphisms show association with ankylosing spondylitis.
Structural basis of semaphorin-plexin signalling.
Impact
GeneRIF
Jones et al., Oxford, United Kingdom. In Nature, 2010
crystal structures of cognate complexes of the semaphorin-binding regions of plexins B1 and A2 with semaphorin ectodomains (human PLXNB1(1-2)-SEMA4D(ecto) and murine PlxnA2(1-4)-Sema6A(ecto)), plus unliganded structures of PlxnA2(1-4) and Sema6A(ecto)
Structural basis for semaphorin signalling through the plexin receptor.
Impact
GeneRIF
Takagi et al., Suita, Japan. In Nature, 2010
crystal structures of the semaphorin 6A (Sema6A) receptor-binding fragment and the plexin A2 (PlxnA2) ligand-binding fragment in both their pre-signalling (that is, before binding) and signalling (after complex formation) states
Functional activity of the OCT-1 protein is predictive of long-term outcome in patients with chronic-phase chronic myeloid leukemia treated with imatinib.
Impact
Hughes et al., Adelaide, Australia. In J Clin Oncol, 2010
PURPOSE: Organic cation transporter-1 (OCT-1) activity (OA), a measure of the OCT-1-mediated influx of imatinib into CML mononuclear cells (MNCs), is predictive of major molecular response (MMR) at 12 and 24 months in patients with untreated CML.
Xenobiotic, bile acid, and cholesterol transporters: function and regulation.
Review
Impact
Aleksunes et al., Kansas City, United States. In Pharmacol Rev, 2010
Transporters of the solute carrier family (SLC) comprise a variety of proteins, including organic cation transporters (OCT) 1 to 3, organic cation/carnitine transporters (OCTN) 1 to 3, organic anion transporters (OAT) 1 to 7, various organic anion transporting polypeptide isoforms, sodium taurocholate cotransporting polypeptide, apical sodium-dependent bile acid transporter, peptide transporters (PEPT) 1 and 2, concentrative nucleoside transporters (CNT) 1 to 3, equilibrative nucleoside transporter (ENT) 1 to 3, and multidrug and toxin extrusion transporters (MATE) 1 and 2, which mediate the uptake (except MATEs) of organic anions and cations as well as peptides and nucleosides.
Feeder-free growth of undifferentiated human embryonic stem cells.
Impact
Carpenter et al., Menlo Park, United States. In Nat Biotechnol, 2001
Similar to cells cultured on feeders, hES cells maintained under feeder-free conditions expressed OCT-4, hTERT, alkaline phosphatase, and surface markers including SSEA-4, Tra 1-60, and Tra 1-81.
Value of peptide receptor scintigraphy using (123)I-vasoactive intestinal peptide and (111)In-DTPA-D-Phe1-octreotide in 194 carcinoid patients: Vienna University Experience, 1993 to 1998.
Impact
Virgolini et al., Vienna, Austria. In J Clin Oncol, 2000
PATIENTS AND METHODS: One hundred ninety-four patients with a verified or clinically suspected diagnosis of a carcinoid tumor were injected with (111)In-DTPA-D-Phe(1)-OCT for imaging purposes, while 133 patients underwent scanning with both (123)I-VIP and (111)In-DTPA-D-Phe(1)-OCT in random order.
More papers using OCT antibodies
Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
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Mukhopadhyay Asok et al., In The Indian Journal of Medical Research, 2002
... H 7.4) at 4°C for 24 h, and frozen in commercial optimal cutting temperature (OCT) medium (Leica Microsystems Nussloch GmbH, Germany) ...
A simplified in situ hybridization protocol using non-radioactively labeled probes to detect abundant and rare mRNAs on tissue sections.
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Gibson Greg, In PLoS ONE, 1997
... Tissue was obtained with a post-mortem interval of 10 minutes, embedded in OCT freezing medium (Triangle Biomedical Science, Durham, NC), and ...
Characterisation and Skin Distribution of Lecithin-Based Coenzyme Q10-Loaded Lipid Nanocapsules
Supplier
Duan Mingxing et al., In Nanoscale Research Letters, 1996
... 2-Propanol and optimal cutting temperature compound (OCT) were purchased from Leica Microsystem (Germany) ...
Hypoxia marker labeling in tumor biopsies: quantification of labeling variation and criteria for biopsy sectioning.
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Deb Sumitra, In PLoS ONE, 1996
... A 5 micron cryosection in OCT was obtained using Leica ...
Epithelial-mesenchymal transformations in early avian heart development
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Toes René EM et al., In Arthritis Research & Therapy, 1995
... Synovial tissues were collected during the arthroscopy, frozen in Tissue-Tek OCT compound (Sakura Finetek, Zoeterwoude, the Netherlands) and cut into 5 μm slices using a cryotome (Leica CM 1900).
Lectin histochemistry of mammalian endothelium.
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Cai Huaibin, In PLoS ONE, 1986
... After embedding the blocked brains in OCT medium a freezing cryostat was used for sectioning at 15 microns (Leica CM1900, Leica Microsystems GmbH, ...
Cleavage of structural proteins during the assembly of the head of bacteriophage T4
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Rapraeger Alan C. et al., In The Journal of Experimental Medicine, 1969
... Tumors were embedded in optimum cutting temperature (OCT) compound (VWR) and frozen sections were prepared for staining.The SSTN peptides (80–90% pure) were purchased from GenScript Corporation ...
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