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POU class 2 homeobox 1

Oct-1, Organic Cation Transporter 1
The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010] (from NCBI)
Top mentioned proteins: OCT, Oct-2, CAN, ACID, HAD
Papers using Oct-1 antibodies
The transactivating effect of HSV-1 ICP0 is enhanced by its interaction with the PCAF component of histone acetyltransferase
Banfield Bruce W., In PLoS ONE, 2008
... A rabbit anti-cyclinT1 antibody (sc-10750), a rabbit anti-Cdk9 antibody (sc-8338), a mouse anti-Oct-1 antibody (sc-8024), and control pre-immune rabbit or mouse IgGs were purchased from Santa Cruz Biotechnology.
Distinguishing regulatory DNA from neutral sites.
Fugmann Sebastian D., In PLoS ONE, 2002
... anti-NFI (H-300), anti-C/EBPβ (C19), anti-GATA2 (H116), normal rabbit IgG (Santa Cruz Biotechnology, Santa Cruz, CA), anti-Oct1 (Abcam Inc., Cambridge, MA) and ...
Papers on Oct-1
MRP3 as a novel resistance factor for sorafenib in hepatocellular carcinoma.
Takayama et al., Tokushima, Japan. In Oncotarget, Feb 2016
Likewise, when expression of membrane transporter proteins was determined, there were no significant differences in expression levels of BSEP, MDR1, MRP2, BCRP, MRP4 and OCT1 between resistant clones and parent cells.
The inhibitory effects of camptothecin (CPT) and its derivatives on the substrate uptakes mediated by human solute carrier transporters (SLCs).
Zhou et al., Harbin, China. In Xenobiotica, Feb 2016
The substrate uptakes of OAT1, OCTN1 and OCTN2 were significantly decreased in the presence of CZ112, while CPT-11 potently down-regulated the transport activity of OCT1 and OCT3. 5.
Metformin modulates apoptosis and cell signaling of human podocytes under high glucose conditions.
Eisenreich et al., Berlin, Germany. In J Nephrol, Feb 2016
We found that hPC express organic cation transporter 1 which is the major uptake transporter of metformin.
The non-metabolized β-blocker nadolol is a substrate of OCT1, OCT2, MATE1, MATE2-K and P-glycoprotein, but not of OATP1B1 and OATP1B3.
Fromm et al., In Mol Pharm, Jan 2016
We therefore investigated nadolol as a potential substrate of the hepatic uptake transporters OATP1B1, OATP1B3, and OCT1 and of the renal transporters OCT2, MATE1, and MATE2-K expressed in HEK cells.
Rapid Method to Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in OCT1-transfected HEK Cells.
Giacomini et al., In Drug Metab Dispos, Jan 2016
Values obtained for intracellular space (mean±SEM; μL /106 cells) of monolayers of human embryonic kidney cells (HEK-EV) and cells overexpressing human organic cation transporter 1, OCT1 (HEK-OCT1), 1.21±0.07
Prostaglandin transporter (OATP2A1/SLCO2A1) contributes to local disposition of eicosapentaenoic acid-derived PGE3.
Tamai et al., Kanazawa, Japan. In Prostaglandins Other Lipid Mediat, Jan 2016
PGE3 uptake was assessed in HEK293 cells transfected with OATP2A1/SLCO2A1, OATP1B1/SLCO1B1, OATP2B1/SLCO2B1, OAT1/SLC22A6, OCT1/SLC22A1 or OCT2/SLC22A2 genes, compared with HEK293 cells transfected with plasmid vector alone (Mock).
OCT1 and imatinib transport in CML: is it clinically relevant?
White et al., Adelaide, Australia. In Leukemia, Oct 2015
The human organic cation transporter 1 (OCT1; SLC22A1) has been reported to be the main influx transporter involved in imatinib uptake into CML cells.
The Pharmacogenetics of Tramadol.
Brøsen et al., Odense, Denmark. In Clin Pharmacokinet, Aug 2015
The metabolic enzymes cytochrome P450 (CYP) 3A4, CYP2B6, and CYP2D6 and the various transporters [adenosine triphosphate-binding cassette B1/multidrug resistance 1/P-glycoprotein, organic cation transporter 1, serotonin transporter (SERT), norepinephrine transporter (NET)] and receptor genes (opioid receptor μ 1 gene) give possible genetic differences that might affect the pharmacokinetics and/or pharmacodynamics of tramadol.
Role of organic cation transporters in drug-drug interaction.
Koepsell, Würzburg, Germany. In Expert Opin Drug Metab Toxicol, 2014
INTRODUCTION: Organic cation transporters OCT1, OCT2 and OCT3 expressed in the small intestine, liver, brain and other organs play important roles in absorption, excretion and distribution of cationic drugs.
Emerging roles of metal solute carriers in cancer mechanisms and treatment.
McKeage et al., Auckland, New Zealand. In Biopharm Drug Dispos, 2014
For example, the transport of platinum-based anticancer drugs has been reported to be influenced by the expression and activities of OCT1-3 (SLC22A1-3), OCTN1/2 (SLC22A4/5), CTR1/2 (SLC31A1/2) and MATE1/2 (SLC47A1/2) solute carriers.
Personalized therapeutics for levofloxacin: a focus on pharmacokinetic concerns.
Zhou et al., Hangzhou, China. In Ther Clin Risk Manag, 2013
Transporters such as organic anion-transporting polypeptide 1A2, P-glycoprotein, human organic cation transporter 1, and multidrug and toxin extrusion protein 1 are involved in the pharmacokinetics of LVX.
Oncosecretomics coupled to bioenergetics identifies α-amino adipic acid, isoleucine and GABA as potential biomarkers of cancer: Differential expression of c-Myc, Oct1 and KLF4 coordinates metabolic changes.
Nagrath et al., United States. In Biochim Biophys Acta, 2012
Our findings establish the impact of Oct1, KLF4 and c-Myc on cancer bioenergetics and evidence a link between oncosecretomics and cellular bioenergetics profile.
Oct-1 acts as a transcriptional repressor on the C-reactive protein promoter.
Agrawal et al., Johnson City, United States. In Mol Immunol, 2012
Oct-1 acts as a transcriptional repressor of C-reactive protein expression and it does so by occupying its cognate site on the promoter and also via other transcription factors by an as yet undefined mechanism
A substrate binding hinge domain is critical for transport-related structural changes of organic cation transporter 1.
Koepsell et al., Würzburg, Germany. In J Biol Chem, 2012
A substrate binding hinge domain is critical for transport-related structural changes of organic cation transporter 1.
Impact of protein/protein interactions on global intermolecular translocation rates of the transcription factors Sox2 and Oct1 between DNA cognate sites analyzed by z-exchange NMR spectroscopy.
Clore et al., Bethesda, United States. In J Biol Chem, 2012
data suggest a model for the sequence of binding events involved in synergistic gene regulation by Sox2 and Oct1
Gadd45a transcriptional induction elicited by the Aurora kinase inhibitor MK-0457 in Bcr-Abl-expressing cells is driven by Oct-1 transcription factor.
Santucci et al., Bologna, Italy. In Leuk Res, 2012
AK inhibitor MK-0457 induces the growth arrest DNA damage-inducible (Gadd) 45a through recruitment of octamer-binding (Oct)-1 transcription factor at a critical promoter region for gene transcription and covalent modifications of histone H3.
Functional activity of the OCT-1 protein is predictive of long-term outcome in patients with chronic-phase chronic myeloid leukemia treated with imatinib.
Hughes et al., Adelaide, Australia. In J Clin Oncol, 2010
PURPOSE: Organic cation transporter-1 (OCT-1) activity (OA), a measure of the OCT-1-mediated influx of imatinib into CML mononuclear cells (MNCs), is predictive of major molecular response (MMR) at 12 and 24 months in patients with untreated CML.
Nucleosome dynamics define transcriptional enhancers.
Liu et al., Boston, United States. In Nat Genet, 2010
More importantly, this model also correctly predicted previously unidentified binding sites for other transcription factors present after prolonged androgen stimulation, including OCT1 and NKX3-1.
A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria.
Kwiatkowski et al., Oxford, United Kingdom. In Nat Genet, 1999
Through systematic DNA footprinting of the TNF (encoding tumour necrosis factor, TNF) promoter region, we have identified a single nucleotide polymorphism (SNP) that causes the helix-turn-helix transcription factor OCT-1 to bind to a novel region of complex protein-DNA interactions and alters gene expression in human monocytes.
Drug excretion mediated by a new prototype of polyspecific transporter.
Koepsell et al., Würzburg, Germany. In Nature, 1995
Here we report the isolation of a complementary DNA from rat kidney that encodes a 556-amino-acid membrane protein, OCT1, which has the functional characteristics of organic cation uptake over the basolateral membrane of renal proximal tubules and of organic cation uptake into hepatocytes.
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