The Pharmacogenetics of Tramadol.
Odense, Denmark. In Clin Pharmacokinet, Aug 2015
The metabolic enzymes cytochrome P450 (CYP) 3A4, CYP2B6, and CYP2D6 and the various transporters [adenosine triphosphate-binding cassette B1/multidrug resistance 1/P-glycoprotein, organic cation transporter 1, serotonin transporter (SERT), norepinephrine transporter (NET)] and receptor genes (opioid receptor μ 1 gene) give possible genetic differences that might affect the pharmacokinetics and/or pharmacodynamics of tramadol.
Role of organic cation transporters in drug-drug interaction.
Würzburg, Germany. In Expert Opin Drug Metab Toxicol, 2014
INTRODUCTION: Organic cation transporters OCT1, OCT2 and OCT3 expressed in the small intestine, liver, brain and other organs play important roles in absorption, excretion and distribution of cationic drugs.
Nucleosome dynamics define transcriptional enhancers.
Boston, United States. In Nat Genet, 2010
More importantly, this model also correctly predicted previously unidentified binding sites for other transcription factors present after prolonged androgen stimulation, including OCT1 and NKX3-1.
Drug excretion mediated by a new prototype of polyspecific transporter.
Würzburg, Germany. In Nature, 1995
Here we report the isolation of a complementary DNA from rat kidney that encodes a 556-amino-acid membrane protein, OCT1, which has the functional characteristics of organic cation uptake over the basolateral membrane of renal proximal tubules and of organic cation uptake into hepatocytes.