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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Occludin

Occludin
This gene encodes an integral membrane protein which is located at tight junctions. This protein may be involved in the formation and maintenance of the tight junction. The possibility of several alternatively spliced products has been suggested but the full nature of these products has not been described. [provided by RefSeq] (from NCBI)
Top mentioned proteins: ZO-1, claudin-1, V1a, CAN, ACID
Papers on Occludin
Renal dysfunction in sibs with band like calcification with simplified gyration and polymicrogyria: Report of a new mutation and review of literature.
New
Dalal et al., Hyderābād, India. In Eur J Med Genet, Jan 2016
Band like calcification with simplified gyration and polymicrogyria (BLC-PMG) is a distinct neuroradiological phenotype initially reported as a pseudo-TORCH syndrome and known to result from biallelic mutations in the Occludin(OCLN) gene.
Deficiency of dietary niacin impaired intestinal mucosal immune function via regulating intestinal NF-κB, Nrf2 and MLCK signaling pathways in young grass carp (Ctenopharyngodon idella).
New
Zhou et al., Chengdu, China. In Fish Shellfish Immunol, Jan 2016
Additionally, niacin deficiency decreased mRNA levels of CuZnSOD, MnSOD, GPx, CAT, GST, GR, Claudin b, Claudin 3, Claudin c, Occludin, ZO-1, Claudin 15 and NF-E2-related factor 2 (Nrf2) (P < 0.05), and increased Claudin 12, Kelch-like ECH-associating protein 1a (Keap1a), myosin light-chain kinase (MLCK) and p38 mitogen-activated protein kinase (p38 MAPK) mRNA expression levels in the intestine of young grass carp (P < 0.05), while the mRNA level of Kelch-like ECH-associating protein 1b (Keap1b) did not change (P > 0.05).
Phenotypic and functional characterization of two bovine mammary epithelial cell lines in 2D and 3D models.
New
Dessauge et al., Cameroon. In Am J Physiol Cell Physiol, Jan 2016
Cytokeratin (CK14 and CK19), signal transducer and activator of transcription 5 (STAT5) and other proteins (Occludin and cadherin-1) were analyzed.
The MAPK/ERK-Signaling Pathway Regulates the Expression and Distribution of Tight Junction Proteins in the Mouse Proximal Epididymis.
New
Breton et al., In Biol Reprod, Jan 2016
Occludin was undetectable in the IS of control mice, but PD325901 triggered its expression in TJs.
Retinoic Acid Induced-Autophagic Flux Inhibits ER-Stress Dependent Apoptosis and Prevents Disruption of Blood-Spinal Cord Barrier after Spinal Cord Injury.
New
Xiao et al., Wenzhou, China. In Int J Biol Sci, Dec 2015
RA attenuated BSCB permeability and decreased the loss of tight junction (TJ) molecules such as P120, β-catenin, Occludin and Claudin5 after injury in vivo as well as in Brain Microvascular Endothelial Cells (BMECs).
Dietary alpha-linolenic acid/linoleic acid ratios modulate intestinal immunity, tight junctions, anti-oxidant status and mRNA levels of NF-κB p65, MLCK and Nrf2 in juvenile grass carp (Ctenopharyngodon idella).
New
Feng et al., Chengdu, China. In Fish Shellfish Immunol, Dec 2015
Additionally, ALA/LNA ratio of 1.03 significantly promoted Claudin-3, Claudin-b, Claudin-c, Occludin and ZO-1 gene transcription, whereas reduced Claudin-15a and myosin light-chain kinase mRNA levels in the intestine, suggesting that appropriate dietary ALA/LNA ratio strengthened tight junctions in the intestine of juvenile fish.
Retinoic Acid Prevents Disruption of Blood-Spinal Cord Barrier by Inducing Autophagic Flux After Spinal Cord Injury.
New
Xu et al., Wenzhou, China. In Neurochem Res, Dec 2015
Our data show that RA attenuated BSCB permeability and also attenuated the loss of tight junction molecules such as P120, β-catenin, Occludin and Claudin5 after injury in vivo as well as in brain microvascular endothelial cells.
Regulation of endothelial permeability in the primate corpora lutea: implications for ovarian hyperstimulation syndrome.
Review
New
Wulff et al., Ulm, Germany. In Reproduction, Feb 2015
Several cell junctional proteins are localized to the corpus luteum, including Occludin, Nectin 2, Claudin 1, and Claudin 5, as well as, vascular endothelial (VE)-Cadherin.
[Research on hepatitis C virus entry inhibitor].
Review
Zhu et al., In Bing Du Xue Bao, 2015
the process of HCV entering into host cell is the important step of drug intervention, in which HCV envelope protein El and E2, Host cell factors including Heparan sulfate(HS), CD81, scavenger receptor class B type I (SR-BI), Occludin (OCLD), Claudin (CLDN), low densitity lipoprotein receptor (LDLR), dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN), Liver/lymph node specific ICAM-3-grabbing integrin(L-SIGN), trans- ferrin receptor 1 (TfR1) and so on play a important role.
Identification of Variants of Hepatitis C Virus (HCV) Entry Factors in Patients Highly Exposed to HCV but Remaining Uninfected: An ANRS Case-Control Study.
Misrahi et al., Le Kremlin-Bicêtre, France. In Plos One, 2014
Here we performed direct genomic sequencing of the Claudin-6, Claudin-9, Occludin and Scavenger receptor-B1 (SCARB1) gene coding regions.
The mechanism of HCV entry into host cells.
Review
Cosset et al., Lyon, France. In Prog Mol Biol Transl Sci, 2014
The initial capture of HCV particles by glycosaminoglycans and/or lipoprotein receptors is followed by coordinated interactions with the scavenger receptor class B type I, a major receptor of high-density lipoprotein, the CD81 tetraspanin, and the tight junction proteins Claudin-1 and Occludin.
The Role of Circulating Tight Junction Proteins in Evaluating Blood Brain Barrier Disruption following Intracranial Hemorrhage.
Huang et al., Shantou, China. In Dis Markers, 2014
Concentrations of the tight junction proteins (TJs) Claudin-5 (CLDN5), Occludin (OCLN), and zonula occludens 1 (ZO-1) and vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) were measured by using enzyme-linked immunosorbent assay in serum and cerebrospinal fluid (CSF) samples obtained from patients with ICH.
Hepatitis C virus entry: role of host and viral factors.
Review
Jahan et al., Lahore, Pakistan. In Infect Genet Evol, 2012
CD81, SR-BI, LDL-R, CLDN1, Occludin, DC-SIGN, L-SIGN and Glycosaminoglycans).
Reduced expression of epidermal growth factor receptor, E-cadherin, and occludin in the skin of flaky tail mice is due to filaggrin and loricrin deficiencies.
GeneRIF
Kubota et al., Japan. In Am J Pathol, 2012
The decreased expression of epidermal growth factor receptor (EGFR), E-cadherin, occludin, and SIRT1 in the skin of Flg(ft) mice, compared with those in C57BL/6J mice, is reported.
Dynamic migration of γδ intraepithelial lymphocytes requires occludin.
GeneRIF
Turner et al., Chicago, United States. In Proc Natl Acad Sci U S A, 2012
occludin KO gammadelta T cells are defective in both initial accumulation and migration within the intraepithelial compartment
Matrix metalloproteinase-2-mediated occludin degradation and caveolin-1-mediated claudin-5 redistribution contribute to blood-brain barrier damage in early ischemic stroke stage.
GeneRIF
Liu et al., Hengyang, China. In J Neurosci, 2012
Occludin protein loss and claudin-5 redistribution are detected in ischemic microvessels following middle cerebral artery occlusion.
P-glycoprotein regulates blood-testis barrier dynamics via its effects on the occludin/zonula occludens 1 (ZO-1) protein complex mediated by focal adhesion kinase (FAK).
GeneRIF
Cheng et al., New York City, United States. In Proc Natl Acad Sci U S A, 2012
Findings show that P-glycoprotein (Abcb1a and Abcb1b) structurally interacted with focal adhesion kinase (FAK), creating the occludin/ZO-1/FAK/P-glycoprotein regulatory complex.
Impact of intra- and interspecies variation of occludin on its function as coreceptor for authentic hepatitis C virus particles.
GeneRIF
von Hahn et al., Hannover, Germany. In J Virol, 2011
show that murine OCLN can sustain HCVcc entry, albeit with about 5-fold reduced efficiency compared to that of human OCLN
Molecular mechanism of intestinal permeability: interaction at tight junctions.
Review
Hirata et al., Kyoto, Japan. In Mol Biosyst, 2008
Occludin, claudin, junctional adhesion molecules, and the coxsackie virus and adenovirus receptor are the major components of TJs.
High-throughput mapping of a dynamic signaling network in mammalian cells.
Impact
Wrana et al., Toronto, Canada. In Science, 2005
Analysis using self-organizing maps and k-means clustering identified links of the TGFbeta pathway to the p21-activated kinase (PAK) network, to the polarity complex, and to Occludin, a structural component of tight junctions.
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